Clinical trials: sponsored by University of Manchester
Alzheimer Disease
Pilot PET Study of Regional Cerebral Protein Synthesis in Alzheimer's
Measuring the rate of cerebral protein synthesis (rCPS) may enable us to better-understand the progression of Alzheimer's Disease (AD).
- Trial name
- NCT05491902
- Testing
- [C11] Leucine PET scan, [18F] Flutemetamol PET scan, MRI scan
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cardiovascular Diseases, Cardiovascular Risk Factor
Qualitative Study of Long Term Cardiovascular Risk Prediction in the Emergency Department
One of the most common presentations to ED is chest pain, with the rapid rule out of heart attacks in the emergency department being common place.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Emergencies
- Trial name
- NCT04601922
- Testing
- Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University of Manchester
Dysphagia, Swallowing Disorder
The Effects of Bilateral Cerebellar rTMS on Cortical Function
Swallowing function is controlled by two swallowing centres (one on each half of the brain). There is a dominant and non-dominant swallowing centre.
- Trial name
- NCT03831789
- Testing
- Cerebellar targeted rTMS
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Dysphagia, Parkinson Disease
Neurostimulation for Dysphagia in Parkinson's Disease
This study will explore the effects of 3 different neurostimulation methods on swallowing function in patients with dysphagia secondary to Parkinson's Disease
- Conditions
- Dysphagia, Parkinson Disease, Swallowing Disorder.Other Specified, Brain Diseases
- Trial name
- NCT03253354
- Testing
- repetitive magnetic stimulation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Manchester
Increased Adherence to Wearing Face Coverings
Using Implementation Intentions Plans to Support Public Use of Face Coverings
The aim of the present research is to test the effectiveness of an implementation intention-based intervention for promoting the wearing of face coverings in three key settings, namely: transport, workplaces and leisure…
- Trial name
- NCT05377814
- Testing
- Volitional help sheet
- Where
- United Kingdom
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Parenteral Nutrition
Longitudinal Evaluation of the Impact of Parenteral Nutrition
Patients with type 3 intestinal failure are completely reliant on artificial feeding and often manage this at home; home parenteral nutrition (HPN). HPN therapy is life saving for these patients.
- Trial name
- NCT04234490
- Testing
- Parenteral nutrition
- Where
- United Kingdom
- Volunteers
- 912 people
- Sponsor
- University of Manchester
Bipolar Spectrum Disorder
Client-led Online Therapy for People Diagnosed With Bipolar Disorder
The study aims to investigate the use of Method of Levels therapy (MOL) delivered online via videoconferencing for people who have received a diagnosis of a bipolar spectrum disorder.
- Trial name
- NCT04859647
- Testing
- Method of Levels Therapy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Manchester
Non-Suicidal Self Injury
A Case-Series Examination of a Brief CAT-Informed Intervention (CATCH-Y) for Young People That Have Self-Injured
Non-suicidal self-injury (NSSI), the term used for when somebody purposefully hurts themselves without intending to end their life. Often, it suggests that there are other difficulties going on in someone's life.
- Trial name
- CATCHY (NCT04708262)
- Testing
- Cognitive Analytic Therapy for Containing Self-Harm in Young People
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Manchester
Pregnancy-Related Condition, Unspecified
Does Prone Position Alter Maternal Cardiorespiratory Status?
During pregnancy women may need or choose to undergo physical therapies such as physiotherapy, massage or osteopathy. Recent findings from studies of mothers who had a stillbirth in late pregnancy found that the position in which…
- Trial name
- NCT04586283
- Testing
- Maternal prone position
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Self-harm
Developing a Smartphone-based App to Reduce Self-harm for CAMHS-treated Adolescents
The aim of the present research is to explore whether a brief, smartphone app-based intervention based on psychological theory can help adolescents to avoid self-harming.
- Trial name
- NCT05368701
- Testing
- Volitional Help Sheet for self-harm
- Volunteers
- 90 people
- Sponsor
- University of Manchester
Carcinosarcoma, Endometrial Neoplasms
Does Cediranib With Paclitaxel, or Cediranib and Olaparib, Treat Advanced Endometrial Cancer Better Than Paclitaxel?
The COPELIA trial is evaluating two new tablet medications in endometrial cancer for the first time. It will include 129 women aged 16 years or older with advanced endometrial cancer whose cancer has worsened after their initial…
- Trial name
- COPELIA (NCT03570437)
- Testing
- Paclitaxel, Cediranib, Olaparib
- Where
- 15 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- University of Manchester
Anxiety, Low Mood
Group-based Metacognitive Therapy for Burns and Plastics Patients
Serious burns and other traumatic or disfiguring injuries represent a significant public health burden. Survivors often need intense medical or surgical treatment, including plastic surgery.
- Trial name
- NCT04959916
- Testing
- Group Metacognitive Therapy
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Manchester
Self-Harm
Using Implementation Intentions to Reduce Self-harm
The aim of the present research is to explore whether a brief intervention based on psychological theory can help people to avoid self-harming.
- Trial name
- NCT04420546
- Testing
- Volitional help sheet
- Where
- United Kingdom
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Vision, Low
Mobile Electronic Devices for Visual Impairment
Mobile electronic devices (MED) including, smartphones and tablets, offer a new type of assistive technology for visually-impaired people (VIP).
- Trial name
- MED4VI (NCT03560765)
- Testing
- MED, Buddy
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Manchester
Osteoarthritis, Knee, Osteochondral Defect
The Impact of Covid-19 on Patients Waiting for Knee Surgery
The Covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. These delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times.
- Conditions
- Osteoarthritis, Knee, Osteochondral Defect, Cartilage Injury, Cartilage Damage
- Trial name
- NCT05124613
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
Cannabis Use
Using Implementation Intentions to Reduce Cannabis Use
The study will recruit frequent users of cannabis (defined at least fortnightly use) and randomize them either to: (1) form implementation intentions by linking situations in which they are tempted to use cannabis with strategies…
- Trial name
- NCT03845842
- Testing
- Volitional help sheet
- Where
- United Kingdom
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Myasthenia Gravis
Immune Profiles in Myasthenia Gravis
The investigators aim to better describe the immune profile in myasthenia gravis (MG), including lymphocyte subset, cytokine and complement profiles; how they differ between patients of different severity, at times of disease…
- Trial name
- NCT05095103
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Rheumatoid Arthritis
PRECISion medicinE Across the Disease Continuum to Prevent and Treat Rheumatoid Arthritis
The study will recruit patients referred to the Rheumatology Out-patient departments. Patients will be recruited to the study or control groups (healthy or disease controls who will be age and sex-matched) as needed.
- Trial name
- PRECISE-RA (NCT04482335)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Ovary Cancer
Validation of Tie2 as the First Tumour Vascular Response Biomarker for VEGF Inhibitors: VALTIVE1
Tumours require a blood supply to provide them with oxygen and nutrients and to enable spread of cancer through blood vessels to other organs (metastasis).
- Trial name
- VALTIVE1 (NCT04523116)
- Where
- 4 sites in United Kingdom
- Volunteers
- 176 people
- Sponsor
- University of Manchester