Clinical trials: sponsored by University of Manchester
COVID, Quality of Life
Does Quality of Life Decline During the COVID-19 Pandemic and Can we Change Behaviour to Improve Poor Quality of Life?
The response to COVID-19 means social isolation/distancing for the majority of the UK. This has the potential to negatively affect all domains of quality of life (QoL).
- Conditions
- COVID, Quality of Life, Behavior, Social Isolation
- Trial name
- NCT04522128
- Testing
- Behaviour Change Technique Intervention to Improve Quality of Life
- Where
- United Kingdom
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Mental Health
Trial of a Ward-Based Intervention to Improve Access to Psychologically-Informed Care and Psychological Therapy for Mental Health In-Patients
The Care Quality Commission (2017) concludes that too often care for people with severe mental health problems on mental health inpatient wards institutionalises people, rather than helping them to have an independent life in the…
- Trial name
- TULIPS (NCT03950388)
- Testing
- Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- University of Manchester
Carotid Artery Diseases, Stroke
Carotid Artery Disease After Stroke (CADAS).
Stroke is a significant medical problem with 150,000 events occurring per year in the UK and incurring healthcare costs of £4 billion per year.
- Conditions
- Carotid Artery Diseases, Stroke, Transient Ischemic Attack
- Trial name
- CADAS (NCT03721523)
- Testing
- 3 Dimensional tomographic Ultrasound, Platelet Aggregometry
- Where
- 3 sites in United Kingdom
- Sponsor
- University of Manchester
Neurofibromatosis 1
Mechanism of Action of Transcranial Direct Current Stimulation in Neurofibromatosis Type 1
Intellectual impairment, particularly working memory deficits are a significant cause of morbidity in children with Neurofibromatosis type (NF1) with long-term implications on academic and occupational functioning.
- Trial name
- NCT04991428
- Testing
- Transcranial direct current stimulation
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Manchester
Obesity, Sweeteners
Mapping the 'Sweet Brain' in Healthy Participants
The human brain has a central role in regulating appetite and food intake. It integrates many metabolic, hedonic and trait-related signals that affect eating behaviour and determine when and how much we eat.
- Trial name
- NCT04162457
- Testing
- Stevia, Glucose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Malnutrition, Frailty
Feasibility of Estimating the Prevalence of Malnutrition, Frailty and Sarcopenia in Older People in UK Biobank, Cross-sectional Study: A Study Protocol
Background: measuring the prevalence of malnutrition, frailty and sarcopenia in same group of older adults is effective in understanding the relation between these conditions.
- Conditions
- Malnutrition, Frailty, Sarcopenia
- Trial name
- NCT04655456
- Where
- United Kingdom
- Volunteers
- 381,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
COVID-19
SCIL-1Ra in COVID-19 Feasibility & PK/PD
The current COVID-19 pandemic is a worldwide healthcare crisis. Of concern is the large number of patients that are/will require mechanical ventilation, and the associated strain that this will place on healthcare resources.
- Trial name
- SCIL_COV19 (NCT04462757)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Manchester
Self Harm
Cognitive Analytic Therapy-informed Containment for Self-Harm (CATCH)
Non-suicidal self-injury (NSSI) is when somebody engages in self-harm, such as cutting, without meaning to end his or her life. A large number of people engage in NSSI for lots of reasons, for example to cope with emotions.
- Trial name
- NCT03853382
- Testing
- Cognitive analytic informed brief therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Manchester
Deglutition, Physiology
Metaplasticity in Human Pharyngeal Motor Cortex
The purpose of the study is to determine the effects of giving 2 doses of brain stimulation through repetitive transcranial magnetic stimulation (rTMS) on swallowing neurophysiology (brain function) in healthy adults.
- Trial name
- NCT03705936
- Testing
- rTMS
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hearing Loss, Functional
A Self-Affirmation Intervention to Promote Hearing Aid Use
Hearing aids are the number one treatment for hearing loss and it is estimated that out of the 2 million of UK individuals who are supplied with hearing aids 1.4 million will use their hearing aids to varying degrees and the…
- Trial name
- NCT04382703
- Testing
- Self-Affirmation Exercise, Control
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Urinary Incontinence, Urinary Incontinence, Stress
Evaluation of a New Technology for the Treatment of Bladder Leakage in Women
Evaluation of a new technology for the treatment of bladder leakage in women. The objective is to compare quality of life and other incontinence associated outcomes between women receiving routine General Practitioner (GP)…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Stress, Urinary Incontinence, Urge
- Trial name
- NCT04059653
- Testing
- Electrical stimulation, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Chronic Pain
The Effectiveness of Neurofeedback for the Treatment of Chronic Pain
This study evaluates the effectiveness of neurofeedback (teaching participants to gain control over their own brainwaves) in chronic pain. The study is made up of four pilot studies.
- Trial name
- NCT04097522
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Depression, Multiple Chronic Conditions
An Approach to "Move a Little & Often" With Health Conditions
People with long term conditions such as diabetes and arthritis, and who also have depression spend a lot of time sedentary during the day. This is because they face many barriers to being active, such as pain and fatigue.
- Trial name
- NCT03537053
- Testing
- A plan to Move a Little and Often
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Manchester
Dysphagia, Swallowing Disorder
tACS and tRNS Studies on Brain Control of Swallowing
Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are two (CE marked medical devices) new, non-invasive (over the scalp) brain stimulation (NIBS) techniques.
- Trial name
- NCT04040803
- Testing
- Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Physical Activity
A Randomised Controlled Trial of a Brief Planning Intervention to Promote Physical Activity
People of low socioeconomic status are more inclined to incur poor health than those of high socioeconomic status. Different factors have been attributed to contributing to such health inequalities, including differences in…
- Trial name
- NCT04325399
- Testing
- Volitional help sheet
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Physical Activity and Wellbeing
Evaluating the Impact of Improvements in Urban Green Space on Older Adults' Physical Activity and Wellbeing: a Natural Experimental Study
Background: Creating or improving urban green space has the potential to be an effective and sustainable way to increase physical activity and improve other aspects of wellbeing in older adults.
- Trial name
- GHIA (NCT03575923)
- Testing
- Urban street greening
- Where
- United Kingdom
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cancer, Depression
An Evaluation of the Psychological Impact of Early Phase Clinical Trials in Cancer Patients.
This is an exploratory prospective observational cohort study to establish the levels of psychological distress in early phase clinical trial patients and evaluate the psychological impact of early phase clinical trials on cancer…
- Conditions
- Cancer, Depression, Anxiety, Hope
- Trial name
- EPIC (NCT03818230)
- Testing
- None (observational study)
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Manchester
Sedentary Behavior
Can an Action-based Help-sheet Help People to Move More and Sit Less.
Implementation intentions support people to turn intentions into action, and "Volitional Help-Sheets" are a tool which helps people to form implementation intentions.
- Trial name
- NCT04280250
- Testing
- Volitional Help-Sheet, Control condition
- Volunteers
- 32 people
- Sponsor
- University of Manchester
Cancer, Cancer Metastatic
Colorectal Liver Metastases: Novel Assessment Tools for Technical Resectability
The CoNoR study aims to assess whether the use of the LiMAx test and the HepaT1ca pre-operative planning magnetic resonance scan impact upon technical resectability decision-making in colorectal liver metastases (CLM).
- Conditions
- Cancer, Cancer Metastatic, Colorectal Cancer, Liver Metastasis Colon Cancer
- Trial name
- CoNoR (NCT04270851)
- Testing
- LiMAx test, HepaT1ca magnetic resonance scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Manchester
Glucose Intolerance, Obesity
Physiological Effects of Stevia Consumption in Humans
This study will evaluate whether long-term consumption of the low calorie sweetener stevia affects glucose tolerance in healthy participants.
- Trial name
- NCT03993418
- Testing
- stevia
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester