Clinical trials: sponsored by University of Manitoba
Covid19
COVID-19 Vaccine Induced Immunity
This study aims to address the following three objectives: 1. Longitudinal evaluation of the development of CMI responses in response to SARS-CoV-2 Vaccine: T cells isolated from the blood of COVID-19 vaccine recipients will be…
- Trial name
- NCT04713163
- Testing
- covid19 vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Appendicitis, Diagnoses Disease
Evaluation of Pressure Algometry in the Clinical Assessment of Acute Abdominal Pain in Children
In this retrospective observational case study, the investigators review the clinical experience with pressure-pain algometry in children with suspected appendicitis.
- Conditions
- Appendicitis, Diagnoses Disease, Pediatric ALL
- Trial name
- NCT04688463
- Volunteers
- 427 people
- Sponsor
- University of Manitoba
Depression, Self-regulation
Building Regulation in Dual Generations
Families who experience maternal mental illness and a variety of chronic stressors are currently underserved by the parenting programs.
- Conditions
- Depression, Self-regulation, Child Development
- Trial name
- BRIDGE (NCT04347707)
- Testing
- BRIDGE Therapy Program
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Sitosterolemia
Effects of Fish Oil and Colesevelam (STAIR7007)
If treatment of colesevelam, fish oil in conjunction with ezetimibe, will lead to further reduction in plasma plant sterol levels in sitosterolemia patients.
- Trial name
- NCT01948648
- Testing
- Colesevelam, Fish Oil, Combination of fish oil and colesevelam
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Manitoba
Healing Surgical Wounds, Pain Measurement
Effects of Laser Stimulation on Wound Healing of Human Palatal Tissue
The purpose of this study is to assess the effects of photobiomodulation (PBM) with an Er:YAG laser on the palatal donor site following subepithelial connective tissue graft (SECTG) surgery.
- Trial name
- NCT03741062
- Testing
- J. Morita AdvErl Evo Er:YAG laser, Control
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Oxidative Stress
Biological Markers of Treatment Response to Repetitive Transcranial Magnetic Stimulation for Depression
The main objective of this study is to determine whether biological stress markers (Oxidized Phosphatidylcholines and Oxylipins) in the blood can be used to predict the efficacy of rTMS in the treatment of major depressive…
- Trial name
- NCT02438748
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cardiovascular Diseases, Cardiovascular Abnormalities
The Effects of the Dietary Supplement CardioFlex Q10 on Reducing Cardiovascular Disease Risk Factors in Adults
Cardiovascular diseases (CVD), primarily heart disease and stroke, are the leading causes of death and prescription drug use in Canada.
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormalities, Heart Attack, Stroke
- Trial name
- NCT03826914
- Testing
- CardioFlex Q10
- Where
- Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Nursing Homes, Aged
BABEL Advance Care Planning in Long-term Care
1.0 SUMMARY Most Canadian nursing home (NH) residents are elderly and frail, have multiple chronic health conditions and impairments, and have dementia.
- Conditions
- Nursing Homes, Aged, Frail Elderly Syndrome, Dementia
- Trial name
- BABEL (NCT03649191)
- Testing
- The BABEL Approach to Advance Care Planning in Nursing Homes, Control group Advance Care Planning
- Where
- 3 sites in Canada
- Volunteers
- 713 people
- Sponsor
- University of Manitoba
ST Elevation Myocardial Infarction (STEMI) Patients
ST Elevation Myocardial Infarction Hemodynamic OutComes: Role of Non-Invasive Cardiac System (SHOCk-NICaS) Study
Proposed novel solution for high-risk heart disease Overall in-hospital mortality among ST elevation myocardial infarction (STEMI) patients is 3-4%, but >50% patients experiencing cardiogenic shock (CS) secondary to STEMI die in…
- Trial name
- SHOCk-NICaS (NCT04586764)
- Testing
- Non-Invasive Cardiac System
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Manitoba
Heart Failure
Heart Failure HemOdynamic Prognostic Evaluation and OutcomE (HF-HOPE) Study
Summary of the HF-HOPE study: Background and existing knowledge gap: As per the Canadian Chronic Disease Surveillance System, about 1 in 12 Canadian adults aged ≥20 live with diagnosed heart disease.
- Trial name
- HF-HOPE (NCT04581252)
- Testing
- Non-invasive cardiac system
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Manitoba
Rib Fractures, Nerve Block
Erector Spinae Plane Block for Acute Pain Management in the Emergency Department
Rib fractures are a common cause of respiratory distress in trauma patients as poor pain control and subsequent hypoventilation commonly results in lung tissue collapse (atelectasis).
- Trial name
- NCT03590782
- Testing
- Erector Spinae Block
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Nonepileptic Seizures
Treating Non-epileptic Seizures Using Magnetic Brain Stimulation
The purpose of this study is to investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) - a form of non-invasive brain stimulation - to decrease the frequency of psychogenic non-epileptic seizure…
- Trial name
- NCT02796924
- Testing
- MagStim Rapid2 Transcranial Magnetic Simulation
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Blastomycosis
Amphotericin-B and Voriconazole for Pulmonary Blastomycosis
All patients with pulmonary blastomycosis requiring mechanical ventilation will have their blood concentrations measured for the antifungal drugs, amphotericin-B and voriconazole; as well as an analysis of the susceptibility of…
- Trial name
- BLASTO (NCT02283905)
- Testing
- amphotericin-B, voriconazole
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
Obsessive-Compulsive Disorder
The Use of Magnetic Brain Stimulation to Treat Obsessive Compulsive Disorder, a Pilot Study
The purpose of this study is two-fold: first, to observe the effect of one session of repetitive transcranial magnetic stimulation (rTMS) on the error-prediction abilities of patients with obsessive compulsive disorder (OCD) as…
- Trial name
- NCT02541812
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Spinal Cord Injury, Paraplegia
Functional Electrical Stimulation With Rowing as Exercise After Spinal Cord Injury
Currently, those with spinal cord injury (SCI) demonstrate increased prevalence of obesity (75%) cardiovascular disease (30 - 50%), type II diabetes (21%) and osteoporosis in the legs (100%) when compared to the general…
- Conditions
- Spinal Cord Injury, Paraplegia, Tetraplegia
- Trial name
- FES (NCT02602639)
- Testing
- Functional electrical stimulation rowing (Odstock 4 channel neuromuscular stimulator with Concept 2 Rower)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Manitoba
Medication Adherence
Daily Delivery and Supervision of Psychotropic Medication for High-Risk Patients With Severe/Persistent Mental Illness
The main study intervention is the daily witnessing of participant self-administration of medications by trained pharmacy staff to ensure compliance.
- Trial name
- NCT03766503
- Testing
- Daily
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chronic Pain
Self-compassion for Chronic Pain Virtual Group Treatment Program
As a result of COVID-19 and measures taken by the Canadian Government to reduce the transmission of the virus, in-person psychology services have been suspended. Psychology services are now being conducted via video conferencing.
- Trial name
- NCT04413006
- Testing
- Self-Compassion for Chronic Pain Virtual Group Treatment Program
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Manitoba
Hypercholesterolemia, Cardiovascular Disease
Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention
The objective of this study is to utilize information on associations between genetic predisposition pertaining to multiple single nucleotide polymorphisms (SNPs) and the degree of responsiveness of low-density lipoprotein…
- Trial name
- GenePredict-PS (NCT02765516)
- Testing
- Plant sterols
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Post-Operative Confusion, Delirium
Tight End-tidal Gas Control During Anesthesia to Decrease Postoperative Delirium Anesthetic Management
Respiratory end-tidal gas control is a fundamental of anesthetic management. The range of end-tidal (ET) O2 and CO2 during the conduct of anesthesia is far outside that found in the awake state.
- Conditions
- Post-Operative Confusion, Delirium, Anesthesia Complication
- Trial name
- NCT04406350
- Testing
- Intraoperative tight control of respiratory end-tidal gases
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Alveolar Bone Loss, Tooth Loss
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
A Clinical Trial to study the effectiveness between two, tooth socket grafting materials namely, Freeze Dried Bone Allograft (human derived bone particles) and Leukocytic-Platelet Rich Fibrin (the patient's own centrifuged…
- Trial name
- NCT03331185
- Testing
- Freeze Dried Bone Allograft, L-PRF clot
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba