Clinical trials: sponsored by University of Michigan
Eosinophilic Esophagitis
Patient-Centered Decision Support for Eosinophilic Esophagitis
The study team is conducting this project to learn more about how patients with eosinophilic esophagitis (EoE) like to use and receive educational materials about treatment options and treatment decision making.
- Trial name
- NCT06817213
- Testing
- General education control, Decision support tool
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Michigan
Metastatic Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
Escalating Cycle 1 Dose of Lu-177-PSMA-617 for the Treatment of Metastatic Castration Resistant Prostate Cancer
This phase I trial studies the safety, side effects, and treatment cycle 1 best dose of Lu-177-PSMA-617 in patients with prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low…
- Trial name
- ESCENDO (NCT07682649)
- Testing
- Biospecimen Collection, Computed Tomography, Gallium Ga 68 Gozetotide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostate Carcinoma
Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial
This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer.
- Trial name
- UPRISE (NCT07526545)
- Testing
- Biopsy Procedure, Diagnostic Procedure, Electronic Health Record Review
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Type 2 Diabetes, Insulin Resistance
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents.
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease
- Trial name
- NCT06007404
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Caries,Dental
Artificial Intelligence (AI) for Proximal Caries Detection and Its Impact on Treatment Threshold
The purpose of this study is to assess the impact of artificial intelligence on proximal caries detection and subsequent treatment decisions of early learners and compare those with outcomes of experienced learners.
- Trial name
- NCT07648212
- Testing
- Review of Radiograph Images
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
- Trial name
- NCT05376267
- Testing
- Therapeutic Hypothermia
- Where
- 65 sites in United States, Australia and 3 more
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Traumatic Brain Injury
Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)
This study is being done to learn how information from blood tests, medical records, and wearable devices that track sleep, activity, and heart rate can help predict how people recover after a concussion.
- Trial name
- NCT07858266
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Consciousness, Level Altered
Investigating Near-Threshold Perception During Ultrasonic Deep Brain Stimulation
This research is studying changes in awareness and metabolism in the brain that may take place in various brain regions stimulated with ultrasound (low-intensity focused ultrasound pulsation or LIFUP) while undergoing magnetic…
- Trial name
- NCT07840521
- Testing
- Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sex Trafficking, Sex Crimes
Rigorous Evaluation of the READY to Stand Curriculum to Prevent the Commercial Sexual Exploitation of Children
The overall goal of this project is to conduct both a process and rigorous outcome evaluation of The Set Me Free Project (SMFP)'s READY to Stand (RTS)© curriculum with an eye toward widespread dissemination to other U.S.
- Conditions
- Sex Trafficking, Sex Crimes, Commercial Sex, Sexual Violence
- Trial name
- Project LIVE (NCT06587529)
- Testing
- The Set Me Free Project's (SMFP) READY to Stand (RTS)© Curriculum
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Kidney Disease, Glomerulopathy
Clinical Phenotyping Resource and Biobank Core of the Michigan O'Brien Renal Center
Chronic kidney disease (CKD) affects approximately 26 million Americans and disproportionately manifests in specific race and ethnic groups. Patients burdened with CKD have significant morbidity and reduced life expectancy.
- Trial name
- C-PROBE (NCT01016613)
- Where
- 5 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stuttering, Adult, Stuttering, Childhood
Transcranial Alternating Current Stimulation (tACS) in Stuttering
The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that…
- Conditions
- Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06740968
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
LGBTQ, Racial Disparities
Lakota Family Acceptance Project Pilot RCT
Although research documents the concerning rates of mental and behavioral health problems (e.g., substance use/initiation) among Indigenous LGBTQ2S+ youth, there is very little known about how to prevent these deleterious issues…
- Conditions
- LGBTQ, Racial Disparities, Family Relationships, Minority Stress
- Trial name
- L-FAP (NCT07865858)
- Testing
- Adapted Lakota Family Acceptance Program
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2, Depressive Symptoms
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one…
- Conditions
- Diabetes Mellitus, Type 2, Depressive Symptoms, Depression
- Trial name
- MenDIII (NCT06574035)
- Testing
- Cognitive Behavioral Therapy, Exercise, Group Discussions - Ongoing Support
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Transcranial Direct Current Stimulation to Improve Gait for Breast Cancer Survivor's Who Received Taxene and/or Platinum Chemotherapy
This clinical trial tests the effect of transcranial direct current stimulation (tDCS) to improve gait in older breast cancer survivors who received taxane and/or platinum chemotherapy.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8
- Trial name
- NCT07864792
- Testing
- Survey Administration, Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan Rogel Cancer Center
Caries Risk, Caries, Dental
Powered vs Manual Toothbrush Use: Its Effect on Caries Risk in Pre-Adolescents
This pilot study aims to evaluate dental caries experience in children ages 8-12 years old through comparing the use of a powered versus manual toothbrush, while using a standardized fluoride toothpaste as the control over the…
- Trial name
- NCT07859553
- Testing
- Powered toothbrush
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Gum Disease
Immediate Implant Provisionalization
This research is studying gum tissue stability of dental implants placed at same appointment as the tooth extraction, with or without a provisional (temporary) crown.
- Trial name
- NCT07732647
- Testing
- Dental implant placement
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
PreDiabetes
The Lifestyle Education About Prediabetes (Leap) Study
This research tested whether a standard version or very low-carbohydrate version of the Diabetes Prevention Program better improves outcomes like blood glucose control and body weight for patients with prediabetes.
- Trial name
- LEAP (NCT05235425)
- Testing
- Standard NDPP, Very low-carbohydrate diet
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Michigan
Atrial Fibrillation
Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation
This clinical trial is being done to determine if metformin, a drug which is normally used in diabetes, can reduce atrial fibrillation in patients who are having an ablation for atrial fibrillation (AF).
- Trial name
- NCT04625946
- Testing
- Metformin, Recommendations for lifestyle modification., AliveCor
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Michigan
Contraceptive Usage, Contraceptive Behavior
A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions
Among people who do not want to get pregnant, some do not use any birth control. This is also called contraceptive nonuse. Common reasons for contraceptive nonuse include concerns about birth control safety or side effects.
- Conditions
- Contraceptive Usage, Contraceptive Behavior, Chronic Disease, Chronic Condition
- Trial name
- NCT07075536
- Testing
- My Health, My Choice Web-Based Contraceptive Decision Tool, Usual Contraceptive Care
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 795 people
- Sponsor
- University of Michigan
AI Companionship
How Do Artificially Intelligent Companions Influence Psychological Outcomes?
This randomized longitudinal study examines how interacting with an artificially intelligent (AI) companion affects psychological well-being, social experiences, and interpersonal attitudes and behaviors over time.
- Trial name
- NCT07858279
- Testing
- AI Companion Interaction
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan