Clinical trials: sponsored by University of Michigan
Heart Failure
A Mobile Application to Promote Self-management and Improve Outcomes in Heart Failure
This study will investigate the effectiveness of two contextual just-in-time adaptive interventions (JITAIs) delivered via a mobile app for heart failure patients.
- Trial name
- NCT04755816
- Testing
- Sodium intervention, Clinical worsening intervention, Educational content
- Where
- 9 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan
Cirrhosis
Chronic Pain Optimization and Management for Relief and Functionality With TEA in Cirrhosis
This study is being done to better understand how the study team can treat pain for people with cirrhosis and depression. Enrolled participants on this feasibility study will be randomized to Transcutaneous Electrical…
- Trial name
- COMFORT (NCT07820917)
- Testing
- Transcutaneous Electrical Acustimulation (TEA)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Amputation
Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs
The overall goal of this project is to model human joint biomechanics over continuously-varying locomotion to enable adaptive control of powered above-knee prostheses.
- Trial name
- NCT06138977
- Testing
- Powered prosthesis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Type2diabetes, Foot Ulcer
Non-weight Bearing Exercise for Accelerated Healing of Diabetic Foot Ulcers
The goal of this study is to improve the therapeutic management of diabetic foot ulcers (DFU). The main questions to answer are if a program of non-weight bearing exercise helps the DFU heal faster than standard wound care.
- Trial name
- NCT05603273
- Testing
- non-weight bearing exercise
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Michigan
Chronic Low-back Pain
Algorithm-informed Decision-making to Advance Pain Treatment
Researchers are exploring how certain personal factors, such as symptoms, health history, and lifestyle, may help predict which treatments will work best for someone.
- Trial name
- ADAPT (NCT07731750)
- Testing
- Algorithmically informed randomization (taking into account phenotypes), Physical Therapy (PT) and Exercise, Cognitive-Behavioral Therapy for Pain (PRISM-CBT)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
ACL, Anterior Cruciate Ligament
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects.
- Conditions
- ACL, Anterior Cruciate Ligament, ACL Injury
- Trial name
- Mi-SPA (NCT06529692)
- Testing
- Split-Belt Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan
Stuttering, Developmental Stuttering
Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering
This research is studying the use of low-intensity focused ultrasound (LIFU; a mild, noninvasive acoustic stimulation technique) in a small number of people to learn about its safety as a treatment for stuttering.
- Trial name
- NCT07668882
- Testing
- High DC LIFU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Cigarette Smoking
Remote Interventions for Menthol Cigarette Use
The purpose of this study is to evaluate whether a digital, incentive-based program, used in conjunction with traditional quitline (QL) services, can be beneficial to quitline callers who smoke menthol cigarettes.
- Trial name
- NCT07356297
- Testing
- Quitline (QL), Mobile incentive-based intervention
- Volunteers
- 1,200 people
- Sponsor
- University of Michigan
Cannabis Use
Activity-Based Intervention to Address Cannabis Use
This study is being completed to test a method to promote patient-centered outcomes among people who use cannabis behaviors.
- Trial name
- NCT07813442
- Testing
- Motivational and Behavioral Economics Informed Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Social Determinants of Health (SDOH), Health Care Utilization
Healthy Moms Healthy Babies Pilot Project Evaluation
This study is designed to learn whether providing additional resources to home visiting agencies in Michigan's Maternal Infant Health Program (MIHP) help them better serve families with high levels of need for basic services.
- Trial name
- HMHB (NCT07817407)
- Testing
- Enhanced Billing Opportunities, Discharge Visit Only
- Where
- United States
- Volunteers
- 10,927 people
- Sponsor
- University of Michigan
Healing Wound, Alveolar; Wound
Ultrasound for Socket Healing Evaluation
The design is a single blinded, dual comparative study of ultrasound versus micro-CT/LASCA in one study group. Up to a total of 140 subjects registered will be recruited.
- Conditions
- Healing Wound, Alveolar; Wound, Alveolar Bone Loss, Image
- Trial name
- NCT06017193
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Constipation
Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
The study is being completed to test the pilot implementation of a rapid clinical care pathway for chronic constipation in the University of Michigan Gastroenterology clinic.
- Trial name
- NCT06352827
- Testing
- Survey
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Michigan
Surgery, Analgesics, Opioids
Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination
The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from surgery.
- Trial name
- MEDSAFE (NCT05991687)
- Testing
- In-home drug disposal pouch, Mail-in prepaid envelope
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Eating Behavior
Mother-Baby Study - Caloric Compensation Index (COMPX)
The study will test a model of biobehavioral mechanisms involved in the development of a system of emotion, attachment, and nutritive intake in the mother-infant dyad and the association of this system with maternal feeding…
- Trial name
- NCT06072664
- Testing
- Caloric Compensation Index (COMPX)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetic Foot Ulcer, Diabetic Foot
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care…
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetes
- Trial name
- NCT06104969
- Where
- 9 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of Michigan
Eating Behavior
Mother-Baby Study - Relative Reinforcing Value (RRV)
The study will test a model of biobehavioral mechanisms involved in the development of a system of emotion, attachment, and nutritive intake in the mother-infant dyad and the association of this system with maternal feeding…
- Trial name
- NCT06072651
- Testing
- Relative Reinforcing Value of Food
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Childhood, Obesity
Mother-Baby Study - Observational
The rate of weight gain in the first year of life is risk factor for future obesity. The study will test (1) a model of l mechanisms underlying the development of emotion, attachment, and nutritive intake; and (2) the association…
- Trial name
- NCT06039878
- Testing
- Bonding-Evoked Oxytocin, Distress Relieving Effects of Sucrose, Hedonic Response to Sucrose
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Eating Behavior
Mother-Baby Study - Eating in the Absence of Hunger (EAH)
The study will test a model of biobehavioral mechanisms involved in the development of a system of emotion, attachment, and nutritive intake in the mother-infant dyad and the association of this system with maternal feeding…
- Trial name
- NCT06072638
- Testing
- Eating in Absence of Hunger
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Endogenous Cushing Syndrome, Adrenal Insufficiency
A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement
The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace…
- Conditions
- Endogenous Cushing Syndrome, Adrenal Insufficiency, Hypercortisolism
- Trial name
- NCT06430528
- Testing
- Osilodrostat
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Prostate Cancer
Genomics in Michigan to AdJust Outcomes in Prostate canceR (G-MAJOR) for Men With Newly Diagnosed Favorable Risk Prostate Cancer
This study seeks to determine the clinical impact of Gene Expression Classifier (GEC) testing in prostate cancer care while also developing a pragmatic approach for improved GEC clinical use and future study.
- Trial name
- NCT04396808
- Testing
- Decipher, Prolaris, Oncotype Dx Genomic Prostate Score (GPS)
- Where
- 8 sites in United States
- Volunteers
- 805 people
- Sponsor
- University of Michigan Rogel Cancer Center