Clinical trials: open to volunteers, sponsored by University of Michigan
Health Behaviors, Functional Decline
Training Community Members to be Coaches to Deliver the HealthyLifetime Program
The goal of this randomized controlled study is to learn if, in addition to nurses, community members can be trained as health coaches to deliver the HealthyLifetime (HL) program to people without complex chronic health…
- Conditions
- Health Behaviors, Functional Decline, Chronic Disease, Risk Factors
- Trial name
- NCT06616246
- Testing
- HealthyLifetime
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Mental Health
COMPASS: A Comprehensive Mobile Precision Approach for Scalable Solutions in Mental Health Treatment
This research study is being conducted to understand if patients benefit from mobile health interventions while waiting for in-clinic mental health treatments.
- Trial name
- COMPASS (NCT06840457)
- Testing
- Mindfulness + Tailored Messages, Mindfulness without Tailored Messages, Cognitive Behavioral Therapy (CBT) + Tailored Messages
- Where
- United States
- Volunteers
- 4,400 people
- Sponsor
- University of Michigan
Hereditary Malignant Neoplasm, Hereditary Neoplastic Syndrome
Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes
This clinical trial tests whether various web-based tools can help improve communication about hereditary cancer risk in families and decrease barriers to genetic testing for relatives of patients with hereditary cancer…
- Trial name
- NCT06927947
- Testing
- Communication Intervention, Health Promotion and Education, Informational Intervention
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Malignant Brain Neoplasm
Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors
This phase I trial tests the safety, side effects and best dose of AdV-HSV1-TK and AdV-Flt3L in combination with valacyclovir for the treatment of patients with primary cancerous (malignant) brain tumors that can be removed by…
- Conditions
- Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Malignant Brain Neoplasm, Resectable Brain Neoplasm
- Trial name
- NCT06914479
- Testing
- Ad-hCMV-Flt3L, Ad-hCMV-TK, Biospecimen Collection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan Rogel Cancer Center
Obesity
Michigan Weight Navigation Program (MiWeigh) Study
The main purpose of this study is to determine whether people who participate in MiWeigh lose more weight than people who receive information about weight loss strategies and programs.
- Trial name
- NCT07465341
- Testing
- MiWeigh, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Prostate Carcinoma
Targeted Early Detection Program in Men at High Genetic Risk for Prostate Cancer
This study evaluates urinary biomarkers and PSA to help determine the best approach to early detection of prostate cancer in patients with an elevated familial risk.
- Trial name
- NCT07645391
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan Rogel Cancer Center
Type 2 Diabetes, Diabetic Kidney Disease
Mechanism of SGLT2 Inhibition in the Kidney
The goal of this open-label, non-randomized clinical trial is to determine what effects, if any, an FDA-approved drug class known as SGLT2 inhibitors (Canagliflozin or INVOKANA) has any protective effects on kidney function in…
- Trial name
- NCT06291155
- Testing
- SGLT2 inhibitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Parkinson Disease
Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation
This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the…
- Trial name
- LRRK2 (NCT07642908)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Minimal Change Disease (MCD), Membranous Nephropathy
Nephrotic Syndrome Study Network
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for approximately 12% of prevalent end stage…
- Conditions
- Minimal Change Disease (MCD), Membranous Nephropathy, Glomerulosclerosis, Focal Segmental
- Trial name
- NEPTUNE (NCT01209000)
- Testing
- Kidney Biopsy
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,200 people
- Sponsor
- University of Michigan
Substance Use, Healthy
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less…
- Trial name
- SIGN (NCT07094061)
- Testing
- fMRI, Questionnaires and surveys, Behavioral tasks and eye tracking
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Nephrotic Syndrome in Children, Focal Segmental Glomerulosclerosis
NEPTUNE Match Study
NEPTUNE Match is an additional opportunity offered to NEPTUNE study participants to prospectively recruit and communicate patient-specific clinical trial matching with kidney patients and their physician investigators.
- Conditions
- Nephrotic Syndrome in Children, Focal Segmental Glomerulosclerosis, Minimal Change Disease, Minimal Change Nephrotic Syndrome
- Trial name
- NEPTUNE Match (NCT04571658)
- Testing
- Communication
- Where
- 16 sites in United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan
Intractable Epilepsy
Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy
The goal of this project is to study how the brain reacts to a small electrical signal. Researchers will be using a novel combination of recording electrodes. The researchers will measure the brain response from these electrodes.
- Trial name
- NCT07014592
- Testing
- stimulating probes and electrodes
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Quiescent Crohn's Disease (CD)
Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease
Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled.
- Trial name
- AIMS-CD (NCT07556718)
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Anxiety, Social Anxiety Disorder
Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity.
- Conditions
- Anxiety, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT06563310
- Testing
- Functional magnetic resonance imaging (fMRI) with Veritable-NF
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Michigan
Bleeding Hemorrhoids, Rectal Evacuation Disorders
Rectal Evacuation Disorders and Straining-associated Symptoms in Bleeding Hemorrhoids
This study aims to understand the mechanisms of straining on anorectal testing, to better help people receive more effective treatment advice.
- Trial name
- NCT07161765
- Testing
- Anorectal manometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Fibromyalgia
Fibromyalgia Sleep A to ZZZ Study
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
- Trial name
- NCT06567886
- Testing
- Light Therapy, Sleep Stabilization
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Michigan
Obesity, Metabolic Syndrome
Exercise Effects on Adipose Tissue Structure and Function
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group).
- Conditions
- Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance
- Trial name
- LG (NCT04812314)
- Testing
- Exercise, No exercise
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Pre-Exposure Prophylaxis (PrEP), HIV Prevention
A Self-administered PrEP Decisional Aid for Dissemination With HIV Self-test Kits (DASH)
People using HIV self-testing (HIVST) need access to quality HIV-prevention programming, including education and exploration of pre-exposure prophylaxis (PrEP) - an effective biomedical prevention tool that continues to expand in…
- Trial name
- DASH (NCT07614165)
- Testing
- PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Low-back Pain
Clinician Satisfaction With the VERABAND™
The VERABAND™ is a newly-developed, disposable, wearable activity monitor. The researchers will assess clinician satisfaction with the usability and likelihood of clinical adoption of the newly-developed, disposable, wearable…
- Trial name
- NCT06080464
- Testing
- VERABAND information
- Where
- 3 sites in United States
- Volunteers
- 360 people
- Sponsor
- University of Michigan
Pregnancy
Michigan Contraceptive Access, Research, and Evaluation Study Children: Phase 1
This project builds on the Michigan Contraceptive Access Research and Evaluation Study (M-CARES) to evaluate the long-term effects of mothers' access to free contraceptives and reductions in unintended pregnancies on their…
- Trial name
- M-CARES-K (NCT04371900)
- Testing
- Mother receives voucher valued at 100% of cost of name-brand IUD (March 4, 2019-March 31, 2023), Mother receives voucher valued at 50% of cost of name-brand IUD (August 26, 2018-March 3, 2019)
- Where
- 9 sites in United States
- Volunteers
- 4,700 people, healthy volunteers welcome
- Sponsor
- University of Michigan