Clinical trials: sponsored by University of Minnesota
Suicidal Behavior, Suicidal Ideation
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency.
- Conditions
- Suicidal Behavior, Suicidal Ideation, Negative Urgency, Cortical Inhibition
- Trial name
- NCT05652153
- Testing
- Single-/paired-pulse transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Gastrointestinal, Mobile Health
GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer
There are two components to the study: a patient and a clinician study. The clinician study will include one-hour semi-structured interviews with oncology specialists to identify facilitators and barriers to integrating digital…
- Conditions
- Gastrointestinal, Mobile Health, Gastrointestinal Symptoms, Gut Health
- Trial name
- NCT07661017
- Testing
- Stool Sample, App Activity
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cerebral Adrenoleukodystrophy
MT2022-01: MSCs for ALD
This is a single-institution study to evaluate the use of intravenously administered allogeneic, 3rd party mesenchymal stem cells (IV-MSC) in patients with active, cerebral adrenoleukodystrophy (CALD), as a bridge to…
- Trial name
- NCT06030648
- Testing
- Mesenchymal stem cells (IV-MSC)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
PreDiabetes, Heart Rate Variability (HRV)
Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs.
- Conditions
- PreDiabetes, Heart Rate Variability (HRV), Stress and Anxiety, Stress Biomarkers
- Trial name
- NCT06365723
- Testing
- Nature-based Walking, Built-environment/Commercial Walking
- Where
- 3 sites in United States
- Volunteers
- 216 people
- Sponsor
- University of Minnesota
Blood Transfusion
Developing, Implementing and Evaluating Effective Community-facility Interactions to Improve Blood Availability and Transfusion in Three Distinct County Settings in Kenya
The strategy of the CoBAnK study is to establish and enable the function of Community-Facility Transfusion Committees (CFTCs) incorporating diverse representation involving hospital, community, and county leadership, to improve…
- Trial name
- CoBAnK (NCT06142825)
- Testing
- Community-Facility Transfusion Committee (CFTC)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Degenerative Joint Disease, Control Subjects
MRI of the TMJ in Patients With DJD
This observational research is comparative in design, that is assessing the change in qMRI measures in degenerative changes of the TMJ in patients diagnosed with DJD.
- Trial name
- NCT07008690
- Testing
- MRI, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rett Syndrome
Cognitive Function in Rett Syndrome During Trofinetide Treatment
Assessing cognitive functions among individuals with severe intellectual and developmental disabilities (IDD), including RTT, is often challenging due to floor effects of many standardized assessment batteries in this population.
- Trial name
- NCT06705816
- Testing
- None interventional
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries
Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury
The purpose of this study is twofold: (1) Develop a new evaluation scale for mental body representations (MBR, i.e., body awareness and visuospatial body maps) for adults with spinal cord injury (SCI) with and without neuropathic…
- Trial name
- NCT07029802
- Testing
- No intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
SCID, Omenn's Syndrome
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.
- Conditions
- SCID, Omenn's Syndrome, Reticular Dysgenesis, Wiskott-Aldrich Syndrome
- Trial name
- NCT01652092
- Testing
- Alemtuzumab 0.3 mg, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
HIV Infections
Optimizing Implementation of Long Acting Injectable PrEP
Our goal is to optimize LAI-PrEP implementation within the context of other PrEP methods. Our strategy is flexible to allow pivot to include forthcoming PrEP dosing options should they become available
- Trial name
- NCT07649551
- Testing
- Plan-Do-Study-Act
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cough
Stimulation of the Larynx to Treat Unexplained Chronic Cough
Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.
- Trial name
- NCT05273190
- Testing
- Vibrotactile Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Healthy Participants
Cognition and Ultrasound
Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition
- Trial name
- NCT07220655
- Testing
- Low-Intensity Focused Ultrasound (FUS or LIFU)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Adult Participants
The SEAS Study: Sensory Engagement and Activation During Noninvasive Stimulation
Early feasibility study to establish quantitative physiological markers correlated with noninvasive stimulation.
- Trial name
- NCT07606573
- Testing
- External electrical stimulation, Ultrasound stimulation
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Immune-mediated Thrombotic Thrombocytopenic Purpura
A Pilot Study of Efgartigimod for Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)
Immune-mediated Thrombotic thrombocytopenic purpura (iTTP) is a rare, autoimmune disorder characterized by life-threatening episodes of thrombocytopenia, microangiopathic hemolytic anemia and organ damage.
- Trial name
- NCT06831058
- Testing
- efgartigimod
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Immune-related Colitis, Colitis
A Pilot Study Testing the Safety and Feasibility of Restorative Microbiota Therapy (RMT) in Patients With Refractory Immune-checkpoint Inhibitor-related Colitis
Immune-related colitis from immune checkpoint inhibitors (ICI) is a common adverse effect causing significant morbidity and impairment of quality of life (QoL).
- Trial name
- NCT05726396
- Testing
- RMT
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Cannabis Use, Cannabis Use Disorder
Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder
This pilot study will investigate the potential of repetitive transcranial magnetic stimulation (rTMS) to strengthen a neural circuit critical for maintaining abstinence in adolescents and youth with cannabis use disorder (CUD).
- Trial name
- NCT07634835
- Testing
- Magstim SuperRapid2
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Pancreatitis, Chronic; Diabetes; Transplant
Anti-inflammatory Therapy to Improve Outcomes After TPIAT
Patients with severe chronic pancreatitis may be candidates to have their pancreas removed and their islets transplanted into the liver to reduce the risk of diabetes mellitus, a procedure called total pancreatectomy with islet…
- Trial name
- NCT02713997
- Testing
- etanercept, Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
NASH - Nonalcoholic Steatohepatitis, NAS
Hepatic Energy Fluxes in NASH and NAS Patients
Diseases along the nonalcoholic fatty liver disease spectrum, which are tightly coupled to the obesity epidemic, are soon to become the commonest indication for liver transplantation in the United States.
- Conditions
- NASH - Nonalcoholic Steatohepatitis, NAS, Overweight or Obesity, Weight Loss
- Trial name
- NCT03997422
- Testing
- Vertical Sleeve Gastrectomy (VSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 2
Glucose and Activity Tracking for Sedentary Behavior Interventions in Older People With Type 2 Diabetes (TRACK T2D)
The overarching goal of this explanatory mixed methods study is to evaluate how older people living with type 2 diabetes (T2D) integrate continuous glucose monitor (CGM) and activity data in diabetes self-management, and how this…
- Trial name
- NCT07524205
- Testing
- SB Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Healthy Volunteers
Weight Gain Prevention in Adolescents and Young Adults
The investigators believe they key to effective prevention of obesity is early identification of individuals at high risk of excess weight gain and proactive implementation of a comprehensive approach including lifestyle-based…
- Trial name
- NCT06905626
- Testing
- Qsymia 7.5 miligrams (mg)-46 mg Extended Release Capsule
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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