Clinical trials: sponsored by University of Minnesota
Graft Failure, Sickle Cell Disease
Allo HSCT for High Risk Hemoglobinopathies
A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent disorders utilizing allogeneic hematopoietic stem cell transplantation…
- Conditions
- Graft Failure, Sickle Cell Disease, Hemoglobinopathies
- Trial name
- NCT06872333
- Testing
- Alemtuzumab, Total Body Irradiation, Cell Infusion
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia
MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.
A phase II trial of a reduced intensity conditioned (RIC) allogeneic hematopoietic cell transplant (HCT) with post-transplant cyclophosphamide (PTCy) for idiopathic severe aplastic anemia (SAA), paroxysmal nocturnal…
- Conditions
- Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia, Acquired Pure Red Cell Aplasia, Paroxysmal Nocturnal Hemoglobinuria
- Trial name
- NCT06412497
- Testing
- Rituximab, Rabbit ATG, Cyclophosphamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Otolaryngologic Surgery
Superficial Cervical Plexus Block for Improved Outcomes in Pediatric Otolaryngologic Surgery
Literature on the use of superficial cervical plexus blocks for ear surgery is sparse in general, and almost non-existent in the pediatric population.
- Trial name
- NCT06023329
- Testing
- ropivacaine, Saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Temporomandibular Disorder
Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study
This study is a randomized, double-blind, sham-controlled feasibility trial designed to assess the acceptability and preliminary efficacy of Transcutaneous Auricular Neurostimulation (tAN) for individuals with Temporomandibular…
- Trial name
- NCT07517172
- Testing
- Transcutaneous Auricular Neurostimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Primary Malignant Peripheral Nerve Sheath Tumors
A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST]
This is a single center Phase 0 "window of opportunity" trial for the treatment of newly diagnosed, PRC2 deficient, primary malignant peripheral nerve sheath tumors (MPNSTs) with a short course of the combination of mirdametinib…
- Trial name
- NCT06693284
- Testing
- mirdametinib and vorinostat
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Osteo Arthritis Knee, Arthritis
Geniculate Artery Embolization for Osteoarthritis
The need for exploration of more definitive and cost effective non-arthroplasty treatments of osteoarthritis (OA) has been demonstrated by the orthopedic and health economic research.
- Conditions
- Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
- Trial name
- NCT04456569
- Testing
- Geniculate Artery Embolization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Parkinson Disease
Imaging Core Aim 2, and Udall Project 2 Aim 2
More than one million people in the United States have Parkinson's disease (PD) and the prevalence is expected to double by 2040.
- Trial name
- NCT06998303
- Testing
- Bipolar DBS stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
DNA Repair Disorder, Cockayne Syndrome
Natural History Study for DNA Repair Disorders
This will be a single-center, single-arm, non-interventional natural history study to evaluate the longitudinal clinical course, functional outcome measures, and candidate biomarkers for individuals with DNA repair disorders…
- Conditions
- DNA Repair Disorder, Cockayne Syndrome, Xeroderma Pigmentosum, Trichothiodystrophy
- Trial name
- NCT05484570
- Testing
- Interval History, Physical Examination, ECAB Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Depression Symptoms
Measuring and Enhancing Creativity and Brain Flexibility in Adolescents With Depression
This research is designed to find out if engaging in creative activities will help adolescents with depression have more flexible thinking, start to see and appreciate their own talents, and develop a more positive view of…
- Trial name
- NCT07605975
- Testing
- Creativity Camp
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations occurring in the post-weight loss setting, including neuroendocrine-mediated changes in appetite/satiety…
- Trial name
- NCT04298203
- Testing
- Phentermine-Topiramate, Meal Replacement Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Prostate Cancer
CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone
This is a phase II clinical trial in patients with metastatic castration sensitive prostate cancer. The objective of the study is to determine the efficacy and further define the safety of the treatment combination.
- Trial name
- NCT03934840
- Testing
- Cabazitaxel, Carboplatin, Abiraterone
- Where
- 8 sites in United States
- Volunteers
- 61 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pediatric Obesity
Phentermine/Topiramate in Adolescents With Type 2 Diabetes and Obesity
As the prevalence of obesity rises in the U.S., so does the incidence of pediatric type 2 diabetes (T2D), which is associated with more aggressive disease progression than in adults.
- Trial name
- NCT04881799
- Testing
- Phentermine/Topiramate (Qsymia)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota
Blood Donation
Enhancing Blood Donation at Schools and Beyond in Malawi
First developed in Zimbabwe, Club 25 is an initiative to promote blood donation among young people, who present a low-risk population for the spread of transfusion transmissible infections (TTIs).
- Trial name
- NCT06138899
- Testing
- Club 25
- Where
- Malawi
- Volunteers
- 35,516 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL)
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia, Plasma Cell Leukemia
- Trial name
- NCT01962636
- Testing
- Fludarabine, Cyclophosphamide, Total Body Irradiation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Tics, Tourette Syndrome
CBIT+TMS R33 Phase
Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth 1 and are associated with impaired functioning, emotional and behavioral problems…
- Trial name
- NCT06678737
- Testing
- CBIT +cTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Primary Sclerosing Cholangitis
Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC
This pilot clinical trial will evaluate the initial safety and feasibility of microbiota transplant therapy (MTT) inpatients with primary sclerosing cholangitis (PSC).
- Trial name
- NCT06197308
- Testing
- oral vancomycin and oral amoxicillin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Minnesota
Menopause
Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function
This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function. PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural…
- Trial name
- NCT06490146
- Testing
- No intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Childhood Obesity
Piloting a Family-Based Intervention of Time-Restricted Eating to Treat Obesity
This study will test whether managing the hours during which people eat, called time restricted eating, might help them to lose weight. For this study, one parent and a child will enroll as a group (called a dyad).
- Trial name
- NCT05107726
- Testing
- TRE Group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Relapsed Adult AML, Refractory AML
Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT
This is a multi-institutional Phase I/II study of an allogeneic KIR-HLA mismatched NK cell infusion (AdaptNK) and a short course of subcutaneous interleukin-2 (IL-2) administered after lymphodepleting chemotherapy…
- Conditions
- Relapsed Adult AML, Refractory AML, Acute Myelogenous Leukemia
- Trial name
- NCT07591649
- Testing
- AdaptNK, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cranial Neurosurgery
Feasibility of Transcranial Focused Ultrasound to Measure Brain Tumor
Transcranial focused ultrasound (tFUS) offers a platform for non-invasive imaging and treatment of the brain and pathology of the brain -- allowing high resolution imaging in both spatial and temporal dimensions.
- Trial name
- NCT05755399
- Testing
- Brain imaging using transcranial focused ultrasound (tFUS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
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