Clinical trials: sponsored by University of Minnesota
Parkinsons Disease, Deep Brain Stimulation
Udall Project 1 Aim 4
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and…
- Trial name
- NCT05568199
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries, Paraplegia, Complete
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
- Trial name
- E-STAND (NCT03026816)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Cancer, Cardiovascular Diseases
GC-PRO Intervention
The goal of the GC-PRO study is to try to make genetic counseling better for people of all backgrounds. We are asking participants to complete two surveys and to allow audio recording of their genetic counseling visit.
- Conditions
- Cancer, Cardiovascular Diseases, Prenatal Condition, Reproductive Condition
- Trial name
- NCT06671704
- Testing
- Genetic counseling months 4-15, Genetic counseling months 6-15, Genetic counseling months 8-15
- Where
- United States
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cannabis Use Disorder
Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)
The goal of this study is to understand the changes in neural correlates of reward in adolescents with and without Cannabis Use Disorder (CUD).
- Trial name
- NCT06124846
- Testing
- CB-Abst, CB-Mon
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
TBI (Traumatic Brain Injury)
Stimulating After Recovery From Traumatic Brain Injury
This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and…
- Trial name
- SMART (NCT05327829)
- Testing
- External non-invasive stimulation, COGED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hematologic Malignancy, Acute Leukemia
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
This is a phase II, open-label, prospective study of T cell receptor alpha/beta depletion (TCR α/β TCD) peripheral blood stem cell (PBSC) transplantation for children and adults with hematological malignancies.
- Conditions
- Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia
- Trial name
- NCT05735717
- Testing
- Fludarabine, Busulfan, Melphalan
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Gaucher Disease
Extracellular Vesicles as Potential Biomarkers and Therapeutic Target in Gaucher Disease
This is an observational study intended to generate preliminary data to understand how lysosomal dysfunction can affect the biogenesis of extracellular vesicles, its content and function.
- Trial name
- NCT05843552
- Testing
- no intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Neck Pain
Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy
The broad long-term objective is to develop an objective biomarker for spinal health based on aberrant or abnormal movement patterns during functional activities to better target spinal manipulation therapy (SMT) and other…
- Trial name
- NCT06312696
- Testing
- SMT, Light Massage
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Healthy Volunteers
ChronoMet: Metabolic and Inflammatory Effects of Eating Timing and Quantity
This is an observational study to address the important knowledge gap of the metabolic and inflammatory impact of acute overeating and whether timing of acute overeating may modify these effects.
- Trial name
- NCT06161337
- Testing
- Meals
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Post Traumatic Stress Disorder, Trauma
Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD
This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older.
- Trial name
- NCT07485231
- Testing
- Beetroot Juice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Hysterectomy, Gender Affirming Surgery
A Standardized Counseling Approach to Preoperative Education in Transmasculine Individuals Receiving Gender-affirming Surgery
The intervention will be an educational handout provided to a randomized cohort of patients that reviews the benefits and risks of retaining ovaries vs removing them.
- Trial name
- NCT07324967
- Testing
- Educational Handout
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Gynecologic Cancer, Ovarian Cancer
Intraperitoneal FT536 in Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
This is a single center Phase I clinical trial of FT536 administered intraperitoneally (IP) 3 times a week for one week for the treatment of recurrent gynecologic cancers.
- Conditions
- Gynecologic Cancer, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT06342986
- Testing
- FT536, Fludarabine, CY
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Social Stress, Adolescent Behavior
Neural Correlates of the Shift in Social Buffering of Social Evaluative Threat
The purpose of this experiment is to determine the mechanisms through which parental buffering of stress physiology in response to social evaluative threat diminishes with pubertal development and whether this diminution of…
- Trial name
- NCT04211155
- Testing
- Questionnaires, MRI
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spinal Cord Injury
CE-STAND: Cervical Epidural STimulation After Neurologic Damage
CE-STAND aims to address three areas under-represented in research: chronic, cervical, and autonomic dysfunction. It is both significant and highly impactful, as treating autonomic dysfunction could substantially improve function…
- Trial name
- NCT06410001
- Testing
- Epidural Spinal Cord Stimulation System
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Chronic Pain
Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling
The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network…
- Trial name
- NCT07103135
- Testing
- MagVenture X100 Pro transcranial magnetic stimulation system
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Neurotypical, Cognitively Normal
Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules.
- Trial name
- NCT06127667
- Testing
- aerobic exercise
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute-graft-versus-host Disease
Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids
This multi-center center phase I/II study to establish the lowest possible recommended phase 2 dose (RP2D) of corticosteroids in conjunction with ruxolitinib and uhCG/EGF (a novel combination) for high-risk aGVHD.
- Trial name
- NCT05123040
- Testing
- Ruxolitinib 10 MG Oral Tablet, hCG, Corticosteroids
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Chronic Tic Disorder
Modeling Tic Change During Behavior Therapy for Tics
Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems…
- Trial name
- NCT06270251
- Testing
- CBIT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Laryngeal Dystonia
Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia
Laryngeal dystonia (LD) is a focal dystonia affecting laryngeal muscles, causing involuntary spasms that impair speech production.
- Trial name
- Neuro-VTS-LD (NCT07443891)
- Testing
- Vibrotactile Stimulation (VTS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pregnancy Emesis, Nausea
Alternate Nostril Breathing (ANB) for 1st Trimester Nausea and Vomiting
This is a prospective, two-arm, non-blinded randomized controlled study designed to evaluate the effects of a one-week alternate nostril breathing (ANB) intervention on nausea and vomiting severity in pregnant individuals during…
- Trial name
- NCT07378839
- Testing
- Alternate Nostril Breathing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
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