Clinical trials: sponsored by University of Minnesota
Substance Use Disorders, Methamphetamine Use Disorders
Individualized Neuromodulation of Craving Control for Meth Use Disorders
Drug craving is one of the key aspects of substance use disorders (SUDs) and is associated with continued drug use and relapse. Approximately 70% of those entering treatment will relapse within one year.
- Trial name
- NCT06695637
- Testing
- active cTBS
- Sponsor
- University of Minnesota
Obesity, Insufficient Sleep
Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
The proposed research aims to reduce obesity-related health disparities by promoting healthy lifestyle behaviors among African Americans (AAs), given the high disease burdens associated with low physical activity, insufficient…
- Trial name
- NCT06226077
- Testing
- sleep extension intervention, contact control intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Generalized Anxiety Disorder, Panic Disorder
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder.
- Conditions
- Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder
- Trial name
- NCT05117255
- Testing
- Negative Emotions and Addiction Tools Program (NEAT)- Cognitive Behavioral Therapy, Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Minnesota
Chronic Pain
Improving Spinal Cord Stimulation With ECAPS
The purpose of this study will be to investigate the optimization of spinal cord stimulation with ECAPs in patients with spinal cord implants.
- Trial name
- NCT04938245
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Toothbrush, Gingivitis
Full-mouth Electronic Toothbrush vs. Conventional Electronic Toothbrush
The goal of this randomized, masked-examiner clinical trial is to investigate a full-mouth electronic toothbrush (FMET). The three arms are: 1) FMET + American Dental Association (ADA) approved dentifrice, 2) conventional…
- Conditions
- Toothbrush, Gingivitis, Plaque
- Trial name
- NCT06561204
- Testing
- FMET
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Crohn Disease
FMT for Postop Crohn's Disease
People with Crohn's disease often need surgery. The gut bacteria of people with Crohn's is associated with Crohn's disease coming back after surgery.
- Trial name
- NCT05248191
- Testing
- Capsule fecal microbiota material (cap-FMT), Colonoscopic fecal microbiota material (colo-FMT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Behavioral Problem, Behavioral Problem of Child
Referral Training and eGen Trials
Child and adolescent behavioral health problems are related to the leading causes of youth morbidity and mortality. Parent-focused interventions effectively prevent behavioral health problems such as depression and conduct…
- Trial name
- NCT06695663
- Testing
- Referral and communication skills learning, Written guide to the referral process, Empowered Generations (eGen): parent training
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Psychosis, Schizophrenia
State Representation in Early Psychosis - Project 4
The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis.
- Conditions
- Psychosis, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizoaffective Disorder
- Trial name
- STEP (P4) (NCT05664594)
- Testing
- Computerized Cognitive Training
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Pain
Pec Infiltration With Liposomal Bupivacaine for Breast Surgery
The purpose of this study is to compare pain control after breast surgery using either liposomal bupivacaine or bupivacaine when infiltrated during an ultrasound guided pectoralis 1 and 2 block.
- Trial name
- NCT03599635
- Testing
- liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Minnesota
Approach/Avoidance Behavior
Theta Phase-specific TMS to Modulate Prefrontal Activity
The purpose of this study is to evaluate the causal link between the phase of ongoing theta oscillations in the prefrontal cortex and approach/avoidance (Ap/Av) behavior in adults using theta phase-specific transcranial magnetic…
- Trial name
- NCT05416138
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Metastasis, Solid Tumor
Study of PAT in Patients With Solid Tumor Cancers
This is a single center Phase I study with extension of peptide alarm therapy (PAT) administered by intratumoral (IT) injection during the 1st course of a standard of care intravenous PD-1/PD-L1 inhibitor for the treatment of…
- Trial name
- NCT05338658
- Testing
- Peptide Alarm Therapy (PAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Aphasia, Non-fluent Aphasia
Combining tDCS and CILT in Non-fluent Aphasia
The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current…
- Conditions
- Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
- Trial name
- NCT05561400
- Testing
- tDCS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Colorectal Cancer
Real-Time Feedback (RTFB) to Improve Colonoscopy
To test whether real-time feedback will improve quality of endoscopic examination.
- Trial name
- NCT05241210
- Testing
- AI program for colonoscopy
- Where
- 3 sites in United States
- Volunteers
- 4,150 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spine Metastases, Bone Pain
Radiofrequency Ablation/Bone Augmentation + Radiotherapy vs Radiotherapy Alone
This is a single-center, randomized controlled pilot study of radiofrequency ablation and bone augmentation (RFA/BA) plus radiotherapy (RT) vs. RT alone in patients with metastatic T5-L5 disease of the spine.
- Trial name
- NCT07090122
- Testing
- Radiofrequency ablation and bone augmentation with radiotherapy, Radiotherapy alone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Intracranial Pressure Increase
Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy
This study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.
- Trial name
- ICP Waveform (NCT04046523)
- Testing
- Video ophthalmoscope
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Osteosarcoma
Biology of Osteosarcoma (BOOST) Registry and Biobank
Osteosarcoma is very rare cancer of the bone. The investigator started the BOOST registry and biobank to make sure every patient has the opportunity to participate in research.
- Trial name
- BOOST (NCT03225872)
- Where
- United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Imaging Biomarkers in ALS
The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3…
- Trial name
- NCT02567136
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smokeless Tobacco
Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure
Our goal in this study is to investigate the extent of endogenous nitrosation of nornicotine in smokeless tobacco users as a function of nornicotine content in smokeless products.
- Trial name
- NCT03998735
- Testing
- Herbal Snuff (Smokeless Tobacco)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Anesthesia, Anesthesia Intubation Complication
Effect of Airway Video Library on Intubation in Novices
Endotracheal intubation requires significant training and expertise. This experience can be quite stressful for novice users. To accelerate the learning curve of newly enrolled trainees to assess and secure airway, the…
- Trial name
- NCT04956796
- Testing
- Airway Video Library Training, Conventional Airway Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Alport Syndrome
Alport Syndrome Treatments and Outcomes Registry
ASTOR's primary purpose is to enroll families and patients with a history of Alport syndrome in a central registry. The information we gather will be used as a basis for studies designed to test potential treatments for Alport…
- Trial name
- ASTOR (NCT00481130)
- Where
- United States
- Volunteers
- 655 people
- Sponsor
- University of Minnesota
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