Clinical trials: sponsored by University of Minnesota
Systolic Hypertension, Brachial Artery Flow-mediated Dilation
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
- Trial name
- NCT07109739
- Testing
- POWERbreathe K5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Minnesota
Chronic Lung Disease, Chronic Obstructive Pulmonary Disease
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with…
- Conditions
- Chronic Lung Disease, Chronic Obstructive Pulmonary Disease, Acute Lymphoblastic Leukemia, Heart Transplant
- Trial name
- FLASHLITE (NCT05025774)
- Testing
- Physical activity
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Healthy
Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens
The goal of this research is to determine if consuming one of two study drinks will help enhance the detoxification of multiple environmental toxicants and cancer causing agents, particularly in subjects who are null for…
- Trial name
- NCT03978117
- Testing
- Freeze Dried Watercress Preparation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Thumb Carpometacarpal Osteoarthritis, Thumb Basal Joint Osteoarthritis
Mechanisms of a Dynamic Stability Approach
Background. Arthritis is the leading cause of disability in the United States and osteoarthritis (OA) of the hand affects an estimated 25.6 US residents.
- Trial name
- NCT05247398
- Testing
- Dynamic Stability Exercise Program
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Trigeminal Neuralgia
Trigeminal Neuralgia Electrophysiology
The study intervention is to perform standard somatosensory evoked responses limited to the face during rhizotomy procedures of the gasserian ganglion (trigeminal ganglion) for the treatment of trigeminal neuralgia.
- Trial name
- NCT05269472
- Testing
- Trigeminal Electrophysiology
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Muscle-Invasive Bladder Carcinoma, Radical Cystectomy
Prophylactic Antibiotics in Cystectomy With Diversion
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of…
- Conditions
- Muscle-Invasive Bladder Carcinoma, Radical Cystectomy, Ileal Conduit, Neobladder Diversion
- Trial name
- NCT06190197
- Testing
- Prophylactic antibiotics postoperatively.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Solid Tumor
HCW9218 in Select Advanced Solid Tumors
This is a single center, Phase I dose finding study of HCW9218 for the treatment of advanced/metastatic solid tumor cancer (except pancreatic and primary brain cancers).
- Trial name
- NCT05322408
- Testing
- HCW9218
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Non-Hodgkin Lymphoma, Hodgkin Lymphoma
Auto Stem Cell Transplant for Lymphoma Patients
This is a phase II study of autologous transplant for patients with Hodgkin (HL) and non-Hodgkin lymphomas (NHL) including those who are HIV positive.
- Trial name
- NCT03125642
- Testing
- Etoposide, BCNU, AraC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Healthy Diet, Nutrition, Healthy
Mobile Food Market Cluster Randomized Trial
Mobile food markets have been proposed as a strategy for mitigating health disparities related to poor nutrition and diet/weight-related health conditions because they bring low-cost, healthy food directly to underserved…
- Trial name
- NCT05672186
- Testing
- Full-service market intervention, No intervention
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hematopoietic Cell Transplantation, Mucopolysaccharidosis Type I
Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.
This is a prospective, observational multicenter study to collect blood from patients with mucopolysaccharidosis type IH undergoing laronidase therapy and a stem cell transplant.
- Trial name
- NCT05634512
- Testing
- Laronidase therapy and a stem cell transplant
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus, Hypoglycemia
Role of CGMS Usage in Predicting Risk for Hypoglycemia
This is a clinical study to examine rates hypoglycemia (self-report, EHR review, and review of values from a FDA approved continuous glucose monitoring system (CGMS)). Subjects will wear either blinded or unblinded CGMS.
- Trial name
- NCT03481530
- Testing
- Continuing Glucose Monitor System
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Minnesota
Cystic Fibrosis
Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens
There is plenty of evidence to suggest that the lung is not uniform. The internal surface area is 30 times that of skin, and the different bronchioles/bronchi/alveoli differ greatly in blood perfusion, temperature, oxygen…
- Trial name
- NCT02128711
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries
Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention.
- Trial name
- NCT04379011
- Testing
- Brivaracetam
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Parkinson's Disease (PD)
Novel DBS Device in Parkinson's Disease
The purpose of this research is to test a new recorder that can measure brain activity when stimulation is turned on during deep brain stimulation (DBS) surgery.
- Trial name
- NCT07213999
- Testing
- Novel neural recorder
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Minnesota
Yellow Fever
The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination
Hypothesis: Infections other than HIV can cause LN inflammation and collagen damage to the fibroblastic reticular cell network (FRCn), which will lead to CD4 T cell depletion and impaired vaccine responses.
- Trial name
- NCT04269265
- Testing
- Yellow Fever Vaccine
- Where
- 2 sites in United States, Uganda
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Psychosis, Schizophrenia
Remote State Representation in Early Psychosis
The purpose of this study is to examine state representation in individuals aged 18-30 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis.
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder
- Trial name
- Rem-STEP (NCT05538832)
- Testing
- BrainHQ Computerized Cognitive Training - Visual Perception Training Paradigm, BrainHQ Computerized Cognitive Training - Visual Cognitive Control Training Paradigm
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation
Evaluation of Cessation Preferences of Menthol Smoker
The primary aim of this study is to determine menthol smokers' perception, product preference, and pattern of use across six products including, mint-flavored nicotine gum; non-flavored nicotine gum; mentholated nicotine inhaler…
- Trial name
- NCT02020005
- Testing
- Non-flavored 2mg nicotine gum, Non-flavored 4mg nicotine gum, Mint-flavored 2mg nicotine gum
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Breast Cancer
Efficacy Verification in Early Diagnosis and Management of Lymphedema Through Home Body Water Analyzer
Breast cancer is the second most common cancer in women. One in five women who have been treated for breast cancer develop lymphedema. Lymphedema is a very common result of breast cancer and its treatment.
- Trial name
- NCT06580743
- Testing
- No intervention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries
CREATION: A Clinical Trial of Qigong for Neuropathic Pain Relief in Adults With Spinal Cord Injury
Between 39-67% of the 294,000 Americans who have a SCI suffer from long-term debilitating neuropathic pain, interfering with rehabilitation, general activity, mobility, mood, sleep, and quality of life.
- Trial name
- NCT04917107
- Testing
- Qigong
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
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