Clinical trials: sponsored by University of Minnesota
Very Low Birth Weight Infant, Very Preterm Maturity of Infant
CGM Use in Preterm Infants
Preterm infants (gestational age (GA) at birth < 31 weeks) admitted to the University of Minnesota Masonic Children's Hospital NICU will have a Dexcom G6 sensor Continuous Glucose Monitor (CGM) placed shortly after consent and…
- Conditions
- Very Low Birth Weight Infant, Very Preterm Maturity of Infant, Hyperglycemia
- Trial name
- NCT05436925
- Testing
- Dexcom G6 sensor Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Psychosis, Schizophrenia
State Representation in Early Psychosis
The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis.
- Conditions
- Psychosis, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizoaffective Disorder
- Trial name
- STEP (NCT05273164)
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cognitive Impairment, Dementia
Home Alone: An Intervention for People With Cognitive Impairment Who Live Alone
The goal of this clinical trial is to evaluate a program for adults who live alone and have some cognitive impairment (CI) to see if it is useful and acceptable.
- Conditions
- Cognitive Impairment, Dementia, Memory Loss
- Trial name
- NCT05746390
- Testing
- Home Alone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Minnesota
Behavior
Evaluation of Link for Equity (School Staff Population)
The investigators propose to develop and evaluate Link for Equity, a trauma-informed system of care. Link, a system of support for ACE-affected children, is composed of universal school Trauma-Informed Care.
- Trial name
- NCT04026477
- Testing
- Immediate Universal Trauma-Informed Care and Cultural Humility Training, Waitlisted Universal Trauma-Informed Care and Cultural Humility Training
- Where
- United States
- Volunteers
- 1,612 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Behavior
Evaluation of Link for Equity (Students of Color Population)
The investigators propose to develop and evaluate Link for Equity, a trauma-informed system of care. Link, a system of support for ACE-affected children, is composed of universal school Trauma-Informed Care.
- Trial name
- NCT04026490
- Testing
- Immediate Intervention, Waitlist Intervention
- Where
- United States
- Volunteers
- 518 people
- Sponsor
- University of Minnesota
Hiv
Welcoming by Design Pilot: Reducing Structural Stigma by Changing Clinic Systems and Architectural Design
The purpose of this study is to test the feasibility and acceptability of implementing clinic system changes and physical structures in Uganda to improve aesthetics, welcome, and privacy to reduce HIV stigma, improve…
- Trial name
- NCT05642676
- Testing
- Clinics remodeling
- Where
- United States
- Sponsor
- University of Minnesota
Focal Segmental Glomerulosclerosis
PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant
This is a pilot/feasibility, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to or at the time of kidney transplantation can prevent recurrent FSGS in children…
- Trial name
- NCT03763643
- Testing
- Rituximab, Plasmapheresis
- Where
- 12 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Sepsis, Hypotension
Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock
The Non-Invasive Cardiac Output Monitor (NICOM) is a non-invasive monitor capable of measuring cardiac output (CO) and cardiac index (CI), and stroke volume (SV) and stroke volume index (SVI) based on heart rate.
- Conditions
- Sepsis, Hypotension, Septic Shock
- Trial name
- NCT05630716
- Testing
- NICOM
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- University of Minnesota
Cryptococcal Meningitis
Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis
Cryptococcal meningitis (CM) is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy.
- Trial name
- NCT06414512
- Testing
- AMBITION trial control, Flucytosine
- Where
- 2 sites in Uganda
- Volunteers
- 48 people
- Sponsor
- University of Minnesota
Leukemia, Myelodysplastic Syndromes
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia
RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for…
- Conditions
- Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia
- Trial name
- NCT00357565
- Testing
- filgrastim, busulfan, cyclosporine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Obesity, Diabetes, Gestational
Metabolism, Breastmilk, and Microbiome
The objective of this pilot study is to compare breast milk composition in mothers of three different metabolic states (normal weight, obese, and gestational diabetic) and to determine the extent to which breastmilk components…
- Trial name
- NCT03522597
- Where
- United States
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke
How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?
Combining cortical tDCS with behavioral interventions has been shown to have beneficial outcomes in individuals post-stroke. However, cerebellar tDCS is a fairly new approach for individuals with unilateral cortical stroke and…
- Trial name
- NCT06384495
- Testing
- REAL-A, REAL-C
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 2 Diabetes, Cardiovascular Diseases
Sex Differences in the effecTs of brEaking uP Sedentary Behavior on vascUlar Function in Type 2 Diabetes
Type 2 diabetes (T2D) confers a high risk of cardiovascular disease (CVD), particularly among older adults who tend to be physically inactive.
- Trial name
- NCT05838586
- Testing
- prolonged SB, SB broken 1, SB broken 2
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Cancer, Solid Tumor
MT2021-27 FT538 Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
To determine the maximum tolerated dose (MTD) of FT538 monotherapy when administered via intraperitoneal (IP) catheter and in combination with intravenous (IV) enoblituzumab in patients with recurrent ovarian, fallopian tube, and…
- Conditions
- Cancer, Solid Tumor, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT05708924
- Testing
- FT538, Enoblituzumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Type 1 Diabetes Mellitus, Hypoglycemia
Islet Transplant for Type 1 or Surgical Diabetes
The purpose of this study is to evaluate the safety and efficacy of islet transplants from human cadaver donors into type 1 or surgical diabetes mellitus patients who experience frequent acute or advanced chronic complications…
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Labile Diabetes, End-stage Renal Disease
- Trial name
- EXAX (NCT01606475)
- Testing
- Allogeneic islets of Langerhans
- Where
- United States
- Sponsor
- University of Minnesota
Recurrent Clostridium Difficile Infection, Fecal Microbiota Transplant
Dietary Optimization of Microbiome Recovery Following Fecal Microbiota Transplantation
Recurrent Clostridioides difficle infection (rCDI) is a very significant problem in its own right and current fecal microbiota transplant (FMT) -based therapeutics will benefit from their optimization for this indication.
- Trial name
- NCT05826418
- Testing
- MEND diet, mNICE diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Lower Urinary Tract Symptoms
RISE FOR HEALTH Study
The RISE FOR HEALTH study (RISE) is an initiative of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, which was formed by the NIDDK in 2015 to develop the science to improve bladder health in women and…
- Trial name
- NCT05365971
- Where
- 9 sites in United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
New Onset Atrial Fibrillation, Anesthesia, Local
Paravertebral Block to Reduce the Incidence of New Onset Atrial Fibrillation After Cardiac Surgery
The purpose if this pilot study is to determine if a perioperative infusion of 0.2% ropivacaine via bilateral T3 paravertebral catheters can decrease the incidence of new onset atrial fibrillation following primary CABG and/or…
- Conditions
- New Onset Atrial Fibrillation, Anesthesia, Local, Cardiac Disease
- Trial name
- NCT04472299
- Testing
- Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Minnesota
RV Dysfunction
Paceport Swan-Ganz Data Collection Study
In association with Edwards LifeSciences, the study will aim to develop an algorithm based on right heart (right atrial, right ventricular and pulmonary artery) waveforms for the early detection of RV dysfunction in…
- Trial name
- NCT06812975
- Testing
- No intervention
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Minnesota
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