Clinical trials: sponsored by University of Minnesota
Diabetes Mellitus, Type 2
The Effects of an Intensive Lifestyle Intervention on Employment, Earnings, and Retirement
Starting in 2001, the Look AHEAD study randomized patients with type 2 diabetes to an intensive lifestyle intervention (ILI) focused on weight loss versus a control group receiving diabetes education ("Diabetes Support and…
- Trial name
- NCT04563598
- Testing
- Intensive lifestyle intervention (ILI), Diabetes support and education (DSE)
- Volunteers
- 3,091 people
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia, Myeloid and Monocytic Leukemia
Multi-Ctr PII Cmb.Modality Tx Ruxolitinib, Decitabine, and DLI for Post HSCT in AML/MDS
This is a multi-center, single-arm, open-label, phase II trial for the frontline treatment of relapsed AML or MDS following allo-HCT. Eligible subjects will receive up to 4 cycles of combined modality treatment.
- Conditions
- Acute Myeloid Leukemia, Myeloid and Monocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT04055844
- Testing
- Decitabine, Ruxolitinib, Donor Lymphocyte Infusion (DLI)
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pleural Effusion
Thoracentesis QI Study
Researchers will compare 3 standard of care methods of pleural fluid drainage during therapeutic thoracentesis. Patients are randomized to manual aspiration, vacuum bottle drainage or wall suction methods.
- Trial name
- NCT05424120
- Testing
- Manual aspiration, Wall suction, Vacuum bottle drainage
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Minnesota
Juvenile Myelomonocytic Leukemia
Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)
The investigators hypothesize that long-term disease-free survival (DFS) in patients with JMML can be achieved with a treatment of busulfan (BU), cyclophosphamide (CY) and melphalan (L-PAM) followed by hematopoietic cell…
- Trial name
- NCT00167219
- Testing
- Stem Cell Transplant, Preparative Regimen
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Diabetes Mellitus Type 2
The Effects of an Intensive Lifestyle Intervention for Type 2 Diabetes on Disability Insurance
Starting in 2001, the Look AHEAD study randomized patients with type 2 diabetes to an intensive lifestyle intervention (ILI) focused on weight loss versus a control group receiving diabetes education ("Diabetes Support and…
- Trial name
- NCT04515745
- Testing
- Intensive lifestyle intervention (ILI), Diabetes support and education (DSE)
- Volunteers
- 3,091 people
- Sponsor
- University of Minnesota
Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS)
Relapse Prophylaxis With N-803 for AML and MDS Pts Following Allo HSCT
This is a single-arm, multi-center Phase II trial using IL-15 super-agonist complex (N-803 formerly known as Alt-803) maintenance after allogeneic hematopoietic cell transplant (alloHCT) for acute myelogenous leukemia (AML) and…
- Trial name
- NCT02989844
- Testing
- N-803
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Myeloid Leukemia
Microbiota Changes in Acute Myeloid Leukemia Patients Undergoing Intensive Chemotherapy
This is a prospective, observational study to collect stool and blood from acute myeloid leukemia patients undergoing intensive chemotherapy.
- Trial name
- NCT03728699
- Testing
- Sample Collection Blood, Stool Sample
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Sedentary Behavior
Feasibility of a Yoga Intervention in Sedentary African-American Women
This study aims to test the feasibility, acceptability, safety of a 3-month hatha and restorative yoga intervention to decrease sedentary behavior, stress and blood pressure in sedentary African-American women.
- Trial name
- NCT04710979
- Testing
- Yoga Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity, Adolescent
Phentermine/Topiramate as Preventive Pharmacotherapy for Obesity
This study will test the use of phentermine and topiramate compared with placebo in helping adolescents who are at high risk for developing obesity to lose weight
- Trial name
- NCT05834062
- Testing
- Qsymia and lifestyle management therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Adult Volunteers
A Pilot Feasibility Study of Activated Charcoal in Healthy Volunteers
This is a pilot study designed to test feasibility, tolerability, and safety of medical grade oral Activated Charcoal (AC) in 12 healthy volunteers. To determine the two most palatable and tolerable AC combinations.
- Trial name
- NCT04204772
- Testing
- Activated charcoal and Tap Water, Activated Charcoal and Apple Juice
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Transient Ischemic Attack
Telestroke for Comprehensive Transient Ischemic Attack Care in Acute Stroke Ready Hospitals
TELECAST-TIA is a prospective single-center study evaluating guideline-based transient ischemic attack (TIA) treatment at an Acute Stroke Ready Hospital (ASRH) pre- and post-initiation of a specialist telestroke inpatient…
- Trial name
- TELECAST-TIA (NCT03724110)
- Testing
- Telestroke
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
FIGO Stage III and IV Ovarian Cancer, FIGO Stage III and IV Fallopian Tube Cancer
IP ALT-803 Followed by SQ ALT-803 for Ovarian Cancer
This is a single center, randomized phase II study of an IL-15Rα-Fc super-agonist complex (ALT-803) given as maintenance therapy after the completion of 1st line IV/IP chemotherapy for the treatment of advanced ovarian, fallopian…
- Conditions
- FIGO Stage III and IV Ovarian Cancer, FIGO Stage III and IV Fallopian Tube Cancer, FIGO Stage III Primary Peritoneal Cancer
- Trial name
- NCT03054909
- Testing
- ALT-803 Subcutaneous, ALT-803 Intraperitoneal
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Dementia, Alzheimer Disease
A Proactive Health Monitoring Intervention for Dementia Caregivers
The objective of this 5-year demonstration project is to build on the work of The Lutheran Home Association (TLHA) and conduct an embedded experimental mixed methods evaluation to determine the efficacy of the eNeighbor…
- Trial name
- NCT03665909
- Testing
- Remote activity monitoring system
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Scar
Fractional Laser Therapy and Dermabrasion for Scar Revision
The goals of this study will be to compare the safety and efficacy of fractional photothermolysis (Fraxel) with dermabrasion when used for scar revision.
- Trial name
- NCT01409863
- Testing
- laser and standard diamond fraise dermabrasion
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Monkey Pox
Efficacy and Acceptability of a Monkeypox Curriculum for Disproportionately Impacted Communities
The study team will create an online module via the REDCap platform. The module will include around 5 videos and several infographics covering the topics of symptoms, transmission, prevention, vaccination, and treatment of the…
- Trial name
- NCT05651581
- Testing
- Online module
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiac Transplant
Cytokine Profiling Post-Heart Transplant
Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.
- Trial name
- NCT01643564
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia
Allo HSCT Using RIC for Hematological Diseases
This is a phase II trial using a non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion.
- Conditions
- Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Plasma Cell Leukemia
- Trial name
- NCT02661035
- Testing
- Allopurinol, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Male Pattern Hair Loss, Androgenetic Alopecia
Laser Assisted Delivery of Minoxidil in Androgenetic Alopecia
The objective of this study is to evaluate the safety and efficacy of fractionated ablative 10,600nm CO2 laser assisted delivery of 2% minoxidil solution in the treatment of MPHL.
- Conditions
- Male Pattern Hair Loss, Androgenetic Alopecia, Male Pattern Baldness
- Trial name
- NCT03852992
- Testing
- Post-Laser Minoxidil 2%, At-Home Minoxidil 5%, Laser
- Where
- United States
- Sponsor
- University of Minnesota
Hyperuricemia, Gout
Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C)
Investigators seek to quantify the impact of vitamin C on patient outcomes, including serum urate level, gout-related symptoms, and obesity (measured by BMI) in both healthy Hmong adults and in Hmong patients with hyperuricemia…
- Trial name
- NCT04938024
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Contact Dermatitis, Allergy; Dermatitis
Study on Hypoallergenic Hair Dye
Permanent hair dyes are commonly used in over the counter direct to consumer products and within hair salons. Allergy, also known as contact dermatitis, to hair dye is a well known phenomenon.
- Conditions
- Contact Dermatitis, Allergy; Dermatitis, Dermatitis
- Trial name
- NCT04772482
- Testing
- Sensitivity Patch Testing
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
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