Clinical trials: sponsored by University of Minnesota
Opioid Use Disorder
Behavioral Activation for Opioid Use Disorder
The overall purpose of this pilot study is to evaluate the feasibility and acceptability of values-based behavioral activation (BA) as an adjunct intervention for patients receiving medications for opioid use disorder (OUD) in…
- Trial name
- NCT05262725
- Testing
- Values-based Behavioral Activation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Mal de Debarquement Syndrome
Transcranial Electrical Stimulation for Mal de Debarquement Syndrome
The goal of this study is to determine whether external neuromodulation using transcranial electrical stimulation (TES) can reduce the perception of self-motion that is experienced by patients with MdDS.
- Trial name
- NCT02540616
- Testing
- Transcranial Electrical Stimulation
- Where
- United States
- Sponsor
- University of Minnesota
Post-acute Sequelae SARS-CoV-2 Infection (PASC)
TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms
The overarching goals of this study are to employ cognitive testing to understand how transcranial direct current stimulation (tDCS), when used concurrently with cognitive training tasks, can affect cognitive impairment symptoms…
- Trial name
- NCT05589272
- Testing
- Active tDCS
- Where
- United States
- Sponsor
- University of Minnesota
Stroke
Functional Connectivity In Relation To Proprioception and Sensorimotor Recovery in Stroke Patients (Feasibility Study)
The purpose now is to: 1. identify brain connections related to proprioception to have a better understanding of differences between people with stroke and healthy persons 2.
- Trial name
- NCT02445768
- Testing
- Cognitive multisensory rehabilitation
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Friedreich Ataxia
Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's Ataxia
Friedreich's ataxia is characterized by progressive alterations in the function of the cerebellum accompanied by an atrophy of the spinal cord.
- Trial name
- NCT01776164
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder
Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors
In this pilot study, the feasibility of using tDCS (a non-invasive brain stimulation technique) while performing a task requiring cognitive flexibility will be examined in smokers and initial data will be collected regarding the…
- Trial name
- NCT03386253
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prostate Cancer
Biomarker Study of in Men With PSA Progression on Abi for CR or CS PC (Bio-STAMP)
This is a multicenter, Phase II randomized biomarker-based therapeutic study in metastatic prostate cancer experiencing prostate specific antigen (PSA) only progression (without visceral, bone or lymph node progression) while on…
- Trial name
- NCT05705700
- Testing
- Dutasteride, Abiraterone
- Sponsor
- Masonic Cancer Center, University of Minnesota
Amyotrophic Lateral Sclerosis
Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS
The purpose of this study is to investigate the effects of two treatment techniques called Expiratory Muscle Strength Training (EMST) and Lung Volume Recruitment (LVR) on breathing, swallowing, speech, and cough function in…
- Trial name
- NCT03202017
- Testing
- Expiratory Muscle Strength Training (EMST), EMST + Lung Volume Recruitment (LVR)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Anesthesia
Clinical Evaluation of a Novel Neuromuscular Blockade Monitoring System
This study is designed to formally evaluate the performance of the QTOF, as compared with the newest commercially available NMB monitoring equipment, EMG (the TwitchView).
- Trial name
- NCT04406740
- Testing
- TwitchView EMG Unit, Novel QTOF Device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
AML, Acute Myelogenous Leukemia
Diagnosis and Treatment of Periodontal Disease in Patients With AML
This is a phase 2 randomized controlled trial of pre-chemotherapy periodontal deep cleaning in Acute Myelogenous Leukemia (AML) patients with asymptomatic periodontitis.
- Trial name
- NCT04530695
- Testing
- Scaling and Root Planing
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pre-Diabetes
Interventional Bioremediation of Microbiota in Metabolic Syndrome
The purpose of this study is to determine whether changing the microbial composition in the colon can improve metabolism of sugar in people who are on the verge of developing diabetes (pre-diabetics).
- Trial name
- NCT02730962
- Testing
- Vancomycin, Neomycin, Clindamycin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Adolescent School Connectedness, Adolescent Health
Trial of a Health Promoting School Approach to Positive Youth Development and Wellness Promotion
Assess the effects of a school-based multi-component intervention on school connectedness, school engagement, and developmental assets through a group randomized, participatory trial.
- Conditions
- Adolescent School Connectedness, Adolescent Health, Community Based Participatory Research Methods
- Trial name
- TRUST (NCT02840383)
- Testing
- Delayed Intervention, Intervention
- Where
- United States
- Volunteers
- 811 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking
Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
To determine whether glucobrassicin-rich Brussels sprouts can favorably modify the metabolism of the polycyclic aromatic hydrocarbon deuterated phenanthrene ([D10]phe) in current and former smokers
- Trial name
- NCT02999399
- Testing
- Brussel Sprouts, Deuterated Phenanthrene
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Root Canal Infection, Endodontic Disease
Occurrence of Post-op Pain Following Gentlewave
This is a clinical study that will investigate the occurrence of post-operative discomfort following the use of the Gentlewave System for root canal disinfection and irrigation.
- Conditions
- Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
- Trial name
- NCT03635515
- Testing
- Gentlewave, Standard Endodontic Protocol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
CBT Decoupling, CBT Anxiety Reduction
Dismantling the Components and Dosing of CBT for Co-Occurring Disorders
The purpose of this study is to establish a brief CBT intervention that can largely, if not fully eliminate the deleterious effect of common co-occurring anxiety disorders on alcohol use disorder treatment outcomes.
- Conditions
- CBT Decoupling, CBT Anxiety Reduction, CBT Combined
- Trial name
- CBT (NCT02161211)
- Testing
- De-coupling, Anxiety Reduction, Combined
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus, Insulin Resistance
Bariatric Surgery And Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus
The focus of this proposal is to define the mechanism by which bariatric surgery acutely improves insulin sensitivity. Our central hypothesis is that drastically reduced caloric intake early after Bariatric surgery improves the…
- Trial name
- NCT01882036
- Testing
- Gastric Bypass w/ matched hypocaloric diet, Hypocaloric diet
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Minnesota
Psychosis, Schizophrenia
Targeting Individual Alpha Frequencies to Enhance Perceptual Timing
This is a single-blind randomized within-subject crossover design study that will be conducted in 2 phases. In Phase 1, up to 50 participants, after signing informed consent and determining eligibility, will undergo a baseline…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT04856657
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
Inpatient Referral to Comprehensive Weight Management for Patients With Obesity
Hospitalized patients with obesity who are not already in CWM (comprehensive weight management), or not comfort care/hospice will be identified by the hospitalists then the study dietitian will consent for the patient for…
- Trial name
- NCT04822545
- Testing
- referral to comprehensive weight management clinic
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Cutaneous Nerves CNS Itch
Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function
The purpose of this study is to assess the safety and efficacy of oral clonidine in subjects with symptomatic atopic dermatitis and to assess the safety and efficacy of oral naltrexone in subjects with symptomatic atopic…
- Trial name
- NCT02268448
- Testing
- Clonidine, Naltrexone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Autism Spectrum Disorders
Single Dose Intranasal Oxytocin and Cognitive Effects in Autism
Autism spectrum disorder (ASD) is a group of severe, life-long developmental disorders. Oxytocin (OT) is a neurohormone involved in both repetitive/rigid and social behaviors.
- Trial name
- NCT02493426
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Minnesota
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