Clinical trials: sponsored by University of Minnesota
Dandruff, Seborrheic Dermatitis
Cleansing Device for the Treatment of Scalp and Hair Conditions
The objective of this study is to evaluate an improvement of scalp health after the use of an investigational off-label WaterPik and brush device aimed to massage and cleanse the scalp.
- Conditions
- Dandruff, Seborrheic Dermatitis, Hair Loss
- Trial name
- NCT05319444
- Testing
- Off-brand Waterpik®
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adolescent Obesity
Self-Weighing for Adolescents Seeking Obesity Treatment
99 patients age 12 to <18 years old with obesity (BMI >/=95th percentile), will be randomized to one of three treatment interventions: 1. Usual Care 2. Usual Care plus advice to weigh daily on simple scale 3.
- Trial name
- NCT04837586
- Testing
- Standard Care, Simple Scale, EHR-Connected Scale
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Minnesota
Cryptococcal Antigenemia, HIV-1-infection
Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers
This randomized clinical trial will evaluate the optimal duration of fluconazole therapy and timing of antiretroviral therapy initiation among HIV-infected persons with asymptomatic cryptococcal antigenemia and low cryptococcal…
- Conditions
- Cryptococcal Antigenemia, HIV-1-infection, Cryptococcal Infection, Cryptococcal Meningitis
- Trial name
- NCT07743593
- Testing
- Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole
- Where
- Uganda
- Volunteers
- 505 people
- Sponsor
- University of Minnesota
Acute Pancreatitis
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
The purpose of the study is to identify novel blood-based biomarkers for prediction and diagnosis of infected pancreatic necrosis (IPN) in patients with necrotizing pancreatitis (NP).
- Trial name
- NCT06899087
- Testing
- not interventional
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries, Chronic Pain
The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain
Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce…
- Trial name
- NCT05741788
- Testing
- Various Stimulation Patterns
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Lower Extremity Fracture
Perioperative Nutrition Optimization for Reducing Complications After Surgical Fracture Fixation
The objective of this multi-center, prospective, placebo-controlled, randomized study is to compare oral conditionally essential amino acid (CEAA) supplementation for decreasing the key postoperative complications of…
- Trial name
- NCT07155447
- Testing
- CEAA supplementation
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Hiv
Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach
The goal of this study is to develop and evaluate the effectiveness of a training program to reduce intersectional stigma faced by sexual minorities and people living with HIV (PLWH) in healthcare settings.
- Trial name
- NCT06975176
- Testing
- Stigma reduction intervention
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Recurrent Clostridioides Difficile Infection, Colonic Surgery
Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection
This is a single-center, open-label study for safety and feasibility of IMT in patients undergoing colonic surgery. After consent, individuals of the ages of 18-75 with a history of diverticulitis or sigmoid colon cancer will be…
- Trial name
- NCT06370884
- Testing
- IMT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Hidradenitis Suppurativa
Capsule Microbiota Transplant Therapy for Hidradenitis Suppurativa
HS is relatively common in the United States with a prevalence of 0.1-1.0%. 1 HS has a dramatic impact on quality of life, significantly more so than other chronic skin diseases, such as psoriasis or atopic dermatitis (AD).
- Trial name
- NCT06058520
- Testing
- Fecal Microbiota - lyophilized
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Minnesota
Recurrent Clostridioides Difficile Infection, Colonic Surgery
An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of A Suspension of Freeze-dried Microbiota In Patients Undergoing Colon Resection
This Phase 1 pilot clinical trial that will evaluate the initial safety and feasibility of orally administered preparation of fecal microbiota (MTP-101P) in patients undergoing colon resection.
- Trial name
- NCT06692179
- Testing
- Orally administered preparation of fecal microbiota (MTP-101P)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Epilepsy, Depressive Disorder
RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS
The acute and chronic effects of VNS stimulation on various on the autonomic nervous, cardiovascular, immune, and metabolic systems will be compared from noninvasive and minimally invasive physiological recordings and blood draws…
- Trial name
- NCT06143293
- Testing
- Vagus nerve stimulation device: acute and chronic administration of investigational vagus nerve stimulation parameters
- Where
- 7 sites in United States, Australia
- Volunteers
- 144 people
- Sponsor
- University of Minnesota
Former Smoker, Non-Smoker
Vaped Phenanthrene
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former…
- Trial name
- NCT07134426
- Testing
- D10-phenanthrene
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cancer, HPV Associated Cancer
Increasing HPV Vaccination in Pediatric, Adolescent, and Young Adult (PAYA) Cancer Survivors
The primary objectives of this study are to increase HPV vaccination initiation and 3-dose completion among pediatric, adolescent, and young adult (PAYA) cancer survivors
- Trial name
- NCT05665543
- Testing
- GLAm app
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Developmental Language Disorder, Explicit Intervention
Evaluation of an Explicit Approach
This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and…
- Conditions
- Developmental Language Disorder, Explicit Intervention, Grammatical Language
- Trial name
- NCT04902508
- Testing
- Implicit-only, Explicit-added
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Minnesota
Treatment Resistant Depression
PCS in Severe Treatment Resistant Depression
This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms.
- Trial name
- NCT04124341
- Testing
- Prefrontal Cortical Stimulation (PCS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Infant of Diabetic Mother
Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers
The purpose of this study is to test the hypothesis that maternal probiotic supplementation is associated with infant gut microbiome variation and improved neurodevelopmental outcomes as measured by ERP performance in infants of…
- Trial name
- NCT05467150
- Testing
- Probiotic Supplement
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Minnesota
Stimulant Use Disorder
Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder
The study will recruit 50 adults with stimulant use disorder currently in treatment and abstinent for at least 2 weeks. The study will also recruit up to 10 healthy controls (adults without StUD) for initial study configuration.
- Trial name
- NCT06790576
- Testing
- closed-loop-peak, Open-loop, closed-loop-trough
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals…
- Trial name
- NCT07246993
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Sepsis, Acute Infection
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients.
- Conditions
- Sepsis, Acute Infection, Organ Failure
- Trial name
- NCT05758246
- Testing
- Fisetin-dose 1, Fisetin-dose 2
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- University of Minnesota
Opioid-use Disorder, Opioid Dependence
Neuromodulation and Cognitive Training in Opioid Use Disorder
The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year.
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Abuse
- Trial name
- NCT03773523
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
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