Clinical trials: sponsored by University of Minnesota
Ostomy, Ileal Conduit
Ostomy Simulation for Patient Education Prior to Urologic Bowel Diversion Surgeries
The purpose of this study is to evaluate the feasibility of using a realistic and anatomically accurate 3D printed simulation model for urologic bowel diversion patient education.
- Trial name
- NCT06583577
- Testing
- 3D Ostomy simulator
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Alcohol-Related Carcinoma, Fanconi Anemia
Role of Acetaldehyde in the Development of Oral Cancer
This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points.
- Conditions
- Alcohol-Related Carcinoma, Fanconi Anemia, Oral Cavity Carcinoma
- Trial name
- NCT05973656
- Testing
- Alcohol, Biospecimen Collection, Breath Test
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Tinnitus
Investigating EEG as a Biomarker for Tinnitus Improvement After Bimodal Stimulation
The aim of the proposed study is to investigate the use of resting-state Electroencephalogram (EEG)-Based Brain Entropy (EBDBE) and auditory brainstem responses (ABR) as an objective measure of tinnitus improvement following the…
- Trial name
- NCT07158034
- Testing
- Lenire Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Vagus Nerve Stimulation
How Does Vagus Nerve Stimulation Affect Blood Glucose, Food, and Movement Cravings?
The purpose of this study is to determine the feasibility of using non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) to examine physiological and psychological responses in a college-aged healthy population
- Trial name
- NCT07457372
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Tourette Syndrome, Tic Disorders
Trajectories of Change in Tourette Syndrome
This K23 Career Development Award is designed to provide the training needed for the PI to achieve her long-term career goal of conducting independent, programmatic intervention research in developmental populations.
- Trial name
- NCT06679790
- Testing
- Comprehensive Behavioral Intervention for Tics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Cancer Screening, Transgender
Cervical and Endometrial Cancer Screening in Patients Seeking Gender-Affirming Hysterectomy
This study aims to quantify the rates of cervical cancer screening and endometrial sampling prior to gender-affirming hysterectomy, assess the need for these tests in TGD individuals, and explore patient-centered options for…
- Conditions
- Cancer Screening, Transgender, Gender Diverse Populations
- Trial name
- NCT07075731
- Testing
- No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Type 2 Diabetes
Individualized Diabetes Education Assisted by CGM (IDEA-CGM)
This project will compare medical nutrition therapy personalized by continuous glucose monitor (CGM) feedback to control interventions in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06784375
- Testing
- Unblinded CGM/Nutrition Therapy, Blinded CGM/Nutrition Therapy, Unblinded CGM/No Nutrition Therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Minnesota
Spasmodic Dysphonia, Laryngeal Dystonia
Usability of Vibro-tactile Stimulation to Treat Spasmodic Dysphonia
The general aim of the study was to provide evidence for the usability and feasibility of applying vibro-tactile stimulation (VTS) at home as a non-invasive form of neuromodulation to improve speech in people with spasmodic…
- Trial name
- NCT06111027
- Testing
- Vibro-tactile stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Myeloid Malignancy, Acute Myeloid Leukemia
HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML
This is a Phase I dose finding study of GTB-3650 (anti-CD16/IL-15/anti-CD33) Tri-Specific Killer Engager (TriKE®) for the treatment of select CD33-expressing refractory/relapsed myeloid malignancies in adults ≥ 18 years of age…
- Conditions
- Myeloid Malignancy, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT06594445
- Testing
- GTB-360
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Insufficient Sleep, Physical Inactivity
Social Determinants of Sleep and Obesity
African American adults sleep less and obtain worse quality sleep compared to the national average, and emerging evidence links inadequate sleep with greater morbidity and mortality from chronic diseases such as diabetes…
- Conditions
- Insufficient Sleep, Physical Inactivity, Sedentary Behavior, Obesity
- Trial name
- NCT05698693
- Testing
- Sleep intervention, Contact Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cancer, Radiation Therapy
Capturing Food Intake in Patients Undergoing Radiation Therapy for Cancer
The purpose of this study is to determine the feasibility of capturing daily dietary intake of patients undergoing radiation therapy using a mobile food record.
- Conditions
- Cancer, Radiation Therapy, Dietary Intake
- Trial name
- NCT07682714
- Testing
- Mobile food record using myCircadian Clock app
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Chronic Pain Patients, Medical Cannabis Users
Medical Cannabis and Behavior
This study will assess cognition, neural function, and drug exposure in chronic pain patients who have been prescribed medical cannabis and will differentiate outcomes based on use of specific CBD-dominant versus THC-dominant…
- Trial name
- NCT06808048
- Testing
- Cognitive testing, Task-based fMRI measure of face-name and verbal learning
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Minnesota
Insulin Resistance, Fasting
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
This is an observational study investigating how the metabolic and cell marker changes in Prolonged Fasting in the serum may be used against a cell-based model of disease for therapeutic purposes.
- Trial name
- NCT07216989
- Testing
- Fasting
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Metastatic Breast Cancer
Fast-Her: Fasting Effects on Breast Cancer Treatment
We hypothesize that promoting a fasting state will strengthen the anti-cancer effects of PI3K inhibitors in metastatic breast cancer (MBC) treatment.
- Trial name
- NCT07624617
- Testing
- Normal Eating, Prolonged Fasting
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Alzheimer Disease
DORA and LP in Alzheimer's Disease Biomarkers
The purpose of this study is to see if the sleep aid, lemborexant, can decrease the amount of amyloid-beta and tau in the blood. Amyloid-beta and tau are proteins involved in the disease process leading to Alzheimer's disease.
- Trial name
- NCT06274528
- Testing
- Lemborexant 10 mg, Lemborexant 20mg
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Gaucher Disease Type I, Oxidative Stress
Oxidative Stress and Inflammatory Biomarkers in Gaucher Disease
The objective of this study is to evaluate oxidative stress and/or inflammation in patients with Gaucher disease type I using a series of biomarkers and correlate with measurements of currently used diagnostic biomarkers.
- Conditions
- Gaucher Disease Type I, Oxidative Stress, Inflammation
- Trial name
- NCT02437396
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Sleep, Alzheimer Disease
Sleep Trial to Prevent Alzheimer's Disease
The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.
- Trial name
- SToP-AD (NCT04629547)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use, Cigarette Smoking
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors.
- Conditions
- Tobacco Use, Cigarette Smoking, Nicotine Dependence
- Trial name
- NCT06295757
- Testing
- Cigarettes
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Smoking, Smoking Cessation
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
The investigators aim to address the following specific aims: Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors.
- Conditions
- Smoking, Smoking Cessation, Smoking Reduction
- Trial name
- NCT04783857
- Testing
- Progesterone 200 MG Oral Capsule
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Minnesota
Depression, Hiv
Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV
Depression in HIV occurs commonly and causes poor HIV outcomes with public health implications. Depression prevalence in HIV-infected persons is estimated at 26% compared to 5% in the general population.
- Trial name
- NCT07007221
- Testing
- Metformin, Fluoxetine, Metformin+Fluoxetine
- Sponsor
- University of Minnesota
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