Clinical trials: sponsored by University of Nebraska
Acute Lymphoblastic Leukemia, Pediatric, Pediatric ALL
Healthy Bones, Healthy Life: Habitual Physical Activity on Bone & Metabolic Health in Pediatric Cancer Survivors
This project will examine habitual physical activity, bone health, and insulin resistance in pediatric acute lymphocytic leukemia (ALL) and lymphoma cancer survivors at two time points: baseline and 6 months.
- Conditions
- Acute Lymphoblastic Leukemia, Pediatric, Pediatric ALL, Pediatric Lymphoma, Bone Loss
- Trial name
- HBHL (NCT04472286)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Postoperative Nausea and Vomiting
Comparison of Adding EMEND to PONV/PDNV Treatment Regimen
This study is looking at whether the addition of Aprepitant (Emend), an antiemetic, will provide added efficacy if added to 2 drugs that are already used as a standard of care for post-operative nausea and vomiting and…
- Trial name
- NCT01186029
- Testing
- aprepitant
- Sponsor
- University of Nebraska
Obesity
Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic
Research purpose: The purpose of this pilot study is to assess obese clients for two phenotypes, those testing positive and those testing negative for Food Addiction (FA) (Yale Food Addiction Scale, YFAS) and determining the…
- Trial name
- NCT03431831
- Testing
- Intervention Control, Counselling, Contrave
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy
Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects
The purpose of this study is to see whether Statin drugs will act as anti-inflammatories. The investigators will study this potential anti-inflammatory activity in healthy subjects.
- Trial name
- NCT00874757
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dysphagia, Dysphonia
The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF
This study is to assess the efficacy of intra-operative intravenous non-steroidal anti-inflammatory drug (Ketorolac) versus intravenous (dexamethasone) administration on dysphagia and dysphonia after anterior cervical discectomy…
- Trial name
- NCT04650893
- Testing
- Intravenous Ketorolac, Intravenous Dexamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Artery Disease
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis
This study will determine whether an ankle foot orthosis (AFO) improves walking performance in participants with PAD from its first use.
- Trial name
- NCT02902211
- Testing
- Ankle foot orthosis, Control/standard of care
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Brain Function
Modulation of Spontaneous Cortical Activity by tDCS: BRAIN Initiative I
This study will determine whether transcranial direct current stimulation (tDCS) can be used alter the amplitude of spontaneous neural activity, and thereby modulate cognitive function in healthy adults
- Trial name
- NCT03672747
- Testing
- transcranial direct-current stimulation (tDCS)
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heart Transplant
Impact of Evolocumab in Cardiac Transplant Patients With CAV
Coronary allograft vasculopathy (CAV) is diffusely accelerated atherosclerosis of a transplanted heart. Evolocumab (Repatha) is an FDA-approved drug for lowering low density lipoprotein (LDL) in patients who have not received a…
- Trial name
- NCT03944577
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Nebraska
Smith-Lemli-Opitz Syndrome
Smith-Lemli-Opitz Syndrome and Cholic Acid
The purpose of this study is to determine whether dietary cholic acid therapy benefits people with Smith-Lemli-Opitz syndrome (SLOS) by leading to an increase in plasma cholesterol and reduction in harmful cholesterol precursors.
- Trial name
- NCT03720990
- Testing
- Cholic Acid
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Nebraska
Acute Exercise, Heat Exposure
The Influence of Menthol Gel During Exercise With Heat
The purpose of this study is to examine the human thermoregulatory impact of applying a commercially available menthol gel (BioFreeze) to the skin prior to moderate intensity walking under heated conditions.
- Trial name
- NCT05302804
- Testing
- Menthol Gel, Control Gel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Alzheimer's Dementia, Falls
Wii-Fit For Improving Activity, Gait And Balance In Alzheimer's Dementia
Alzheimer's Dementia (AD) contributes to poor balance, impaired gait and functional status, thereby, increasing the risk of falls. AD is an independent risk factor for hip fractures.
- Conditions
- Alzheimer's Dementia, Falls, Gait Impairment, Balance Impairment
- Trial name
- NCT01002586
- Testing
- Wii-Fit intervention, Walking exercise program
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Nebraska
Acute Exercise, Heat Exposure
The Influence of Capsaicin Gel During Exercise Within the Heat
The purpose of this study is to examine the human thermoregulatory impact of applying a commercially available capsaicin gel to the skin prior to moderate intensity walking under heated conditions.
- Trial name
- NCT05298202
- Testing
- Capsaicin, Control Gel, Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Plasma Cell Myeloma
Enhancing Anti--Tetanus Vaccine Response After Autologous Stem Cell Transplantation
This pilot randomized Phase II trial (10 subjects per arm) will compare immune reconstitution following transplantation of an autologous mobilized graft product to reconstitution following transplantation of a mobilized graft…
- Trial name
- NCT02700841
- Testing
- Melphalan, Peripheral Blood Stem Cell Transplantation--CD34 HSCT, Peripheral Blood Stem Cell Transplantation--AHSCT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Kidney Transplantation, Pancreas Transplantation
Pre-operative Evaluation of Kidney & Pancreas Transplant Patients
Examine the clinical utility of the dobutamine stress contrast echoes and angiograms obtained routinely in the evaluation of patients prior to kidney or pancreas transplantation.
- Trial name
- NCT00580437
- Testing
- Dobutamine Stress Echocardiogram
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Nebraska
Healthy
Impacts of a Combined Berry Extract Supplement on Vascular Function and Oxygen Utility Capacity in Young Adults
The purpose of this study is to investigate the impacts of a combined berry extract supplement (hawthorn berry, tart cherry, and bromelain extracts) on total antioxidant capacity, endothelial function, blood pressure, oxygen…
- Trial name
- NCT04312022
- Testing
- Berry extract
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Total Parenteral Nutrition-Induced Cholestasis
Compassionate Use of Omegaven® for the Treatment of Intestinal Failure Associated Liver Disease in Children
The overall purpose of this study is to determine if replacing standard soybean oil based fat emulsions with Omegaven®, a fish oil based fat emulsion, can reverse or prevent the progression of parenteral nutrition associated…
- Trial name
- NCT02328768
- Testing
- Omegaven
- Where
- United States
- Sponsor
- University of Nebraska
Food Addiction
Differences in Length of Telomere in Food Addicted vs Non Food Addicted Persons
The purpose of this descriptive study is to examine telomere length between two groups of people, those with and those without food addiction and identify possible relationships that may play a role in food addiction, it's…
- Trial name
- NCT05649189
- Testing
- telomere length measure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Nebraska
Pain
Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children
Title: Effect of the DentalVibe injection system on pain during local anesthesia injections in children. Purpose: The purpose of this study is to compare self-reported pain scale measurements using the Wong-Baker FACES pain…
- Trial name
- NCT03374982
- Testing
- DentalVibe
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Nebraska
Family, Critical Care
Mobile App to Promote Family Caregiver Engagement in the Intensive Care Unit
The purpose of this randomized controlled pilot trial is to develop and test mobile app, Intensive Care Unit-Caregiver Activation Response, and Engagement (ICU-CARE).
- Conditions
- Family, Critical Care, Mobile Applications
- Trial name
- ICU-CARE (NCT05157919)
- Testing
- ICU-Care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Nebraska
PIV Catheter Insertion, Vein Visualization
Nurse PIV Insertion Success With and Without Assistive Devices in Patients 0-12 Months of Age
The purpose of this study is to determine if the use of a vein identification assistive device increases nurse PIV insertion success within the first two attempts in children 0-12 months of age when compared to unassisted methods.
- Trial name
- NCT01637987
- Testing
- Unassisted vein visualization, Wee Sight® Transilluminator, VeinViewer® (Christie Digital Systems, Cypress, CA)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Nebraska