Clinical trials: sponsored by University of Nebraska
Small Cell Lung Carcinoma
A Study of Durvalumab Plus Tremelimumab With Chemotherapy in Untreated ES-SCLC
This study is designed to evaluate the safety and tolerability of durvalumab and tremelimumab in combination with intravenous (IV) carboplatin plus (+) etoposide in new patients with extensive-stage small cell lung cancer…
- Trial name
- NCT03963414
- Testing
- Durvalumab + Tremelimumab in combination with carboplatin and etoposide, Durvalumab in combination with carboplatin and etoposide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Nebraska
Refractive Error
First-Sight Refractive Error Correction: Direct Comparison to Autorefraction Results in Children 7 to 18 Years of Age
Proof of concept study to compare the best corrected visual acuity obtained via First-Sight lenses with the autorefraction in children.
- Trial name
- NCT01365884
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Infantile Colic
Infantile Colic: Study of the Efficacy of Lactobacillus GG (ATCC 53103) Plus Chamomile in Breastfeeding Infants
The objective of this study is to determine the efficacy of a product combining the probiotic Lactobacillus GG and chamomile in treating infantile colic in exclusively breast fed infants.
- Trial name
- Colic (NCT03477669)
- Testing
- chamomile/probiotic arm
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Nebraska
HIV Infection
The Lymphoid Tissue Pharmacology of Antiretroviral Drugs
Hypothesis: Antiretroviral drugs (ARVs) with enhanced LT penetration characteristics in vitro and in macaques will translate into an ARV regimen with increased LN and GALT concentrations and a faster decay and more potent…
- Trial name
- NCT02707926
- Testing
- Anti-HIV Agents
- Sponsor
- University of Nebraska
Chronic Periodontitis
Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD)…
- Trial name
- NCT02316652
- Testing
- Scaling and root planing, Scaling and root planing with solution
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Staphylococcus Aureus
Evaluation of Vancomycin Treatment of Infections Due to Staphylococcus Aureus
Objective: The objective of the study is to evaluate the ability of current vancomycin dosing strategies to attain the pharmacodynamic target of an area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio…
- Trial name
- NCT00862862
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Nebraska
Asthma, Dental Caries
Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers
Young children with asthma who use drugs for their asthma are at higher risk for tooth decay. These drugs can cause (1) dry mouth from less saliva secretion and (2) acid mouth that causes teeth to become soft and bacteria to…
- Trial name
- Lollipops (NCT01147835)
- Testing
- Chinese Licorice Root
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Multiple Sclerosis
The Effects of Ethyl-Alpha-Guanido-Methyl Ethanoate on Skin Reactions From Glatiramer Acetate Injections
Participants with multiple sclerosis that are currently treated with glatiramer acetate (GA, Copaxone®) injections and have redness, pain, swelling, itching or a lump at the injection site will be recruited to examine histamine…
- Trial name
- NCT00988988
- Testing
- AGEE cream, 1% Steroid Cream
- Sponsor
- University of Nebraska
Neonatal Sepsis, Sepsis
Probiotics for Prevention Neonatal Infection
Neonatal sepsis (serious infection) continues to be one of the major causes of morbidity and mortality in the newborn period around the world.
- Conditions
- Neonatal Sepsis, Sepsis, Neonatal Infections
- Trial name
- NCT01214473
- Testing
- Synbiotics, Maltodextrin
- Where
- 2 sites in India
- Volunteers
- 4,556 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Diabetic Retinopathy
Effect of Panretinal Photocoagulation on Optic Nerve Head Topography
The purpose of this study is to evaluate the optic nerve head changes consequent to panretinal photocoagulation done for diabetic retinopathy.
- Trial name
- PRP (NCT00767884)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
Central Nervous System Neoplasms
Comparison of Contrast Agents for MRI Perfusion Analysis in Brain Tumor Patients
This study will compare the use of two contrast agents to analyze blood flow characteristics of brain tumors.
- Trial name
- NCT02095353
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Nebraska
Kidney Cancer
Talabostat in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Talabostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well talabostat works in treating patients with metastatic kidney…
- Trial name
- NCT00489710
- Testing
- talabostat mesylate, enzyme inhibitor therapy, flow cytometry
- Sponsor
- University of Nebraska
Hearing Loss
Local Heat-Stress as a Mechanism of Hearing Preservation
This pilot study plans to determine whether or not local heat-stress as a mechanism can help to preserve hearing in adults treated with Cisplatin.
- Trial name
- NCT02872844
- Testing
- ICS AirCal3
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Roux-en-y Anastomosis Site
Hand-sewn and Linear-stapled Roux-en-Y Gastric Bypass: Outcomes
The technique of laparoscopic Roux-en-Y gastric bypass (RYGB) has evolved significantly over the past few decades to minimize complication risks such as strictures.
- Trial name
- NCT03199352
- Testing
- RYGB hand-sewn, RYGB linear-staple
- Sponsor
- University of Nebraska
Blood Stream Infections, Short Bowel Syndrome
Evaluation of 70% Ethanol Lock Solution to Prevent Catheter Related Blood Stream Infections in Pediatric Patients
The purpose of this study is to evaluate the clinical practice of the prophylactic use of ethanol locks for the prevention of catheter related blood stream infections in pediatric intestinal rehabilitation program patients…
- Trial name
- NCT01409772
- Testing
- Ethanol Lock
- Sponsor
- University of Nebraska
Local Anesthesia
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia
The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.
- Trial name
- NCT02647892
- Testing
- lidocaine, sodium bicarbonate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Nebraska
Chronic Hepatitis C
Effects of Genotypes on Interferon Signaling in Chronic Hepatitis C
The objective of this pilot project is to investigate the prognostic criteria for sensitivity of Chronic Hepatitis C (CHC) Genotype 1, patients to IFNa treatment.
- Trial name
- NCT00876174
- Testing
- Blood sampling of peripheral blood mononuclear cells, Blood draw, 20ml peripheral blood mononuclear cells
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Wounds, Infection
Autologous Platelet Gel in Wound Healing of Coronary Artery Bypass Grafting (CABG) Patients
This study will determine if autologous platelet gel (APG) on sternal incision and conduit sites will improve wound healing and decrease infection in coronary artery bypass grafting surgery patients.
- Trial name
- NCT00672672
- Testing
- autologous platelet gel
- Sponsor
- University of Nebraska
Alzheimer Disease, Early Onset, Mild Cognitive Impairment
Effects of Mitochondrial-targeted Antioxidant on Mild Cognitive Impairment (MCI) Patients
Neurodegenerative diseases such as Mild Cognitive Impairment, Alzheimer's, and dementia affect millions of Americans. Although these diseases are heavily researched, there is very little research examining the impact of…
- Trial name
- NCT03514875
- Testing
- MitoQ
- Sponsor
- University of Nebraska
Chronic Hepatitis C
Pilot Comparison of Standard Antiviral Therapy With and Without 12 Weeks of Betaine in Genotype 1 Naive Patients
The primary purpose of the study is to compare the safety and effectiveness of standard treatment for chronic hepatitis C using peginterferon alpha-2a (Pegasys) and ribavirin (Copegus) to those same medications plus a dietary…
- Trial name
- NCT00571714
- Testing
- Peginterferon alpha-2a and ribavirin, Peginterferon alpha-2a , ribavirin and betaine
- Sponsor
- University of Nebraska