Clinical trials: sponsored by University of Nebraska
Maternal Health, Blood Pressure
Protective Assets Reinforced With Integrated Care and TechnologY (PARITY) Feasibility Trial
This study will determine the feasibility and acceptability of the Protective Assets Reinforced with Integrated care and TechnologY (PARITY) program, to test the clinical, behavioral, and strength building efficacy of the PARITY…
- Trial name
- NCT05802615
- Testing
- PARITY, Usual Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Prostatic Cancer
High-dose Brachytherapy Boost With Stereostatic Body Radiation Therapy to Intermediate or Higher Risk Prostate Cancer
The objective of this phase I/II trial is to prospectively evaluate the toxicity and therapeutic efficacy of Stereostatic Body Radiation Therapy (SBRT) to prostate and pelvic lymph nodes in combination with high-dose-rate (HDR)…
- Trial name
- NCT05754580
- Testing
- High Dose Brachytherapy, Stereostatic Body Radiation Therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Nebraska
Parkinson's Disease and Parkinsonism
Biomarker Validation Following Sargramostim Treatment in Parkinson's Disease
Investigators will evaluate the safety of a 48 week regimen of Leukine administered as a weight-based dose at 3 ug/kg/ day for 5 days followed by a 2-day holiday.
- Trial name
- NCT05677633
- Testing
- Sargramostim
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Nebraska
Peripheral Arterial Disease, Painful Diabetic Neuropathy
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition.
- Conditions
- Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain
- Trial name
- NCT06480786
- Testing
- Spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
Type 2 Diabetes
Assessing Continuous Glucose Monitor Use in Underserved Primary Care Patients
Continuous glucose monitoring (CGM) has demonstrated improved outcomes in both type 1 and type 2 diabetes populations in comparison to traditional methods; however, these devices have not been well studied in underserved adult…
- Trial name
- NCT05766488
- Testing
- Continuous Glucose Monitor (CGM), Self-monitoring Blood Glucose (SMBG)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hemiplegic Cerebral Palsy
Hand-Arm Bimanual Intensive Therapy in Virtual Reality Versus Standard Hand-Arm Bimanual Intensive Therapy
The goal of this intervention study is- 1. To determine if a camp that solely uses VR software based on HABIT (HABIT-VR) still improves the motor planning and execution deficits in children with hemiplegic cerebral palsy (HCP)…
- Trial name
- HABIT-VR (NCT05867368)
- Testing
- HABIT-VR, Standard HABIT
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Nebraska
Post Traumatic Stress Disorder
Using Mobile Technology to Address the Trauma Mental Health Treatment Gap
BounceBack Now (BBN) is a self-help, trauma-focused mental health mobile application (app) with automated assessment with treatment guidance and in-app evidence-based treatment support for depression, post-traumatic stress…
- Trial name
- NCT05374408
- Testing
- Aim 2: BounceBack Now (BBN) for Trauma Informed Care Deployment, Aim 1 Participant Focus Groups, Aim 1 BHP Focus Groups
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Recurrent Glioblastoma, Recurrent High-grade Glioma
A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma
The goal of this study is to learn about a type of brain cancer called high-grade glioma. This study is for people who have previously received treatment for brain cancer, but the cancer has come back or gotten worse after…
- Trial name
- NCT06501911
- Testing
- Bicalutamide, Intensity-modulated radiation therapy (IMRT)
- Where
- United States
- Sponsor
- University of Nebraska
Parkinson's Disease, Sleep Fragmentation
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US.
- Trial name
- NCT05070013
- Testing
- Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Trail Making Task, Balance Board
Network Analysis of Bodywide Coordination Supporting Suprapostural Dexterity
Prevailing understandings of movement disorders characterize "broken" movements in a piecewise fashion, for instance, focusing on motor control, muscle tone, posture, or cognition independently of each other.
- Trial name
- NCT07060092
- Testing
- Trail Making Task, Balance board
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Slipping and Falls
Mechanisms of Fall Resistance to Diverse Slipping Conditions
Falls are the leading source of injury for all ages, and for older adults are the primary cause of injury related death. Loss of foot to ground traction accounts for 25-40% of falls, typically referred to as a slip.
- Trial name
- NCT03758040
- Testing
- Slips on Turns, Slips on Slopes
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Opioid Use, Opioid Dependence
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge
Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy.
- Conditions
- Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
- Trial name
- EQUIPPED (NCT05221866)
- Testing
- Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease
Exoskeleton Variability Optimization
Exoskeletons, wearable devices that assist with walking, can improve mobility in clinical populations. With exoskeletons, it is crucial to optimize the assistance profile.
- Trial name
- NCT04338815
- Testing
- Exoskeleton Optimization, Endurance Evaluation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Plaque, Dental
Effectiveness of Plaque Score Detection Techniques
This study investigates the similarity between microbial plaque scores when assessing the entire dentition versus select teeth. The hypothesis posits that plaque buildup on single teeth mirrors that of the entire mouth…
- Trial name
- NCT06511830
- Testing
- Dental Monitoring images
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Sex Trafficking, Sex Crimes
Preventing Commercial Sexual Exploitation of Children
The overall goal of the 5-year project is to conduct both a process and rigorous outcome evaluation of The Set Me Free Projects (SMFP) READY to Stand (RTS) curriculum with an eye toward widespread dissemination to other U.S.
- Conditions
- Sex Trafficking, Sex Crimes, Commercial Sex, Sexual Violence
- Trial name
- Project LIVE (NCT05988398)
- Testing
- READY To Stand Curriculum
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Slip Perturbations
Variability and Specificity in Reactive Stabilization Movements to Diverse Slip Perturbations
Recent research on slips has shown that use of perturbation training to improve specific motor skills to resist slips can vastly reduce falls.
- Trial name
- NCT03755336
- Testing
- Administered Slip Perturbations
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer
Pancreatic cancer, most commonly adenocarcinoma, is the fourth leading cause of cancer death in the United States. The mainstay of management centers on surgical resection (if resectable) and although low (15% to 20%)…
- Conditions
- Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage I Pancreatic Cancer AJCC v6 and v7, Stage IA Pancreatic Cancer AJCC v6 and v7
- Trial name
- NCT03073785
- Testing
- Capecitabine, Fluorouracil, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
Pain, Chronic, Loneliness
The Loneliness Epidemic Tailoring Interventions to Reduce Loneliness and Pain
Approximately 24% of community-dwelling older adults are socially isolated, and over 40% of adults 60 and older report feeling lonely.
- Trial name
- NCT05387447
- Testing
- Conversational Voice Assistant (Enhanced), Conversational Voice Assistant (Standard)
- Where
- 4 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dating Violence, Alcohol Drinking
Evaluation of PRYSHM for LGBTQIA2S+ Youth
The overarching goal of the proposed project is to develop an innovative, online synchronous DV and AU prevention curriculum created specifically for SGMY (ages 15 to 18); conduct a pilot randomized controlled trial to assess its…
- Trial name
- PRYSHM (NCT05521906)
- Testing
- Promoting Resilient Youth with Strong Hearts and Minds (PRYSHM)
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of Nebraska Lincoln
Peripheral Arterial Disease, Peripheral Artery Disease
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients
Peripheral artery disease (PAD) is a common cardiovascular disease, in which narrowed arteries reduce blood flow to the limbs, causing pain, immobility and in some cases amputation or death.
- Trial name
- NCT03506633
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Nebraska