Clinical trials: sponsored by University of Nottingham
Sarcopenia
Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women
In this study will measure differences in how muscle responds to both exercise and protein supplements in healthy women aged 60-69.
- Trial name
- NCT02053441
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sedentary Behavior
Effects of Physical Inactivity on Insulin Sensitivity, Appetite, Energy Balance, and Cardiovascular Responses in Humans.
Physical inactivity is a significant predictor of major non-communicable diseases such as type 2 diabetes (7%), cardiovascular disease (6%), musculoskeletal disorders and some cancers, and has been proposed to be the 4th leading…
- Trial name
- NCT04172090
- Testing
- Control, SIT+E, SIT=E
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Fertility
The Effect of Progesterone on Human Endometrium
This study evaluates the relationship between progesterone levels and endometrial gene expression
- Trial name
- NCT04323683
- Testing
- Microarray
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Fibre and Gas in Irritable Bowel Syndrome
The aim of the study is to investigate how dietary fibre combinations affects gut physiology, particularly colonic gas production.
- Trial name
- EFIGI (NCT03265002)
- Testing
- Inulin, Psyllium, Inulin and psyllium
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Nottingham
Hearing Loss, Sensorineural, Tinnitus, Subjective
Prevalence and Impact on QoL From Ototoxicity in Cancer Survivors
This study will involve collaborating with oncologists in the post-chemotherapy follow-up appointments. The participants who wish to consent to this study will then answer 3 short questionnaires (THI, HHIA and SF-36) about…
- Conditions
- Hearing Loss, Sensorineural, Tinnitus, Subjective, Cancer, Chemotherapeutic Toxicity
- Trial name
- NCT04270916
- Testing
- High frequency pure tone audiometry
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Nottingham
Sarcopenia, Muscle Atrophy
Concurrent Assessment of Skeletal Muscle Mass and Synthesis/Breakdown in Old Age
This study involves minimally-invasive techniques to measure muscle mass, muscle protein breakdown and synthesis simultaneously in older age.
- Trial name
- NCT04114383
- Testing
- D3-Creatine, Deuterium Oxide, D3-3-methylhistidine
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Transient Ischaemic Attack, Stroke
Psychoeducation for Transient Ischaemic Attack and Minor Stroke
Transient Ischaemic Attack (TIA), also called 'ministroke' is characterised by shortlasting symptoms that generally do not cause permanent damage.
- Trial name
- OPTIMISM (NCT02550392)
- Testing
- Psychoeducation
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Nottingham
Low Back Pain
Pain Experience in Individuals With Chronic Low Back Pain
Low back pain is a very common musculoskeletal condition that affects many people each year regardless of age, gender, and ethnicity.
- Trial name
- NCT03972332
- Testing
- Quantitative Sensory Testing
- Where
- United Kingdom
- Volunteers
- 97 people
- Sponsor
- University of Nottingham
Quality of Life, Cancer
Impact on Quality of Life of Long-term Ototoxicity in Cancer Survivors
This project aims to explore, in depth, the burden of hearing loss and tinnitus on cancer survivors. Using semi-structured interviews, audiograms and a variety of validated questionnaires, the specific impact ototoxicity has on…
- Conditions
- Quality of Life, Cancer, Hearing Loss, Sensorineural, Tinnitus, Subjective
- Trial name
- NCT04281953
- Testing
- High frequency audiometry, Short-Form 36-Item Questionnaire (SF-36), Hearing handicap inventory for adults/elderly (HHIA/HHIE)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Lipidemia
Impact of Reducing Dietary Intake of Red and Processed Meat Intake on Fasting Lipemia in Healthy Participants
Excessive meat consumption, particularly of red and processed meat, is associated with increased risk of developing a range of chronic diseases.
- Trial name
- ELM (NCT02907112)
- Testing
- Meat reduction
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Heart Failure, Chronic Kidney Disease
PD-HF: A Trial of Peritoneal Dialysis in Patients With Severe Heart Failure and Chronic Kidney Disease
This trial is to establish whether ultrafiltration by peritoneal dialysis is a clinically effective treatment for patients with severe heart failure and moderate chronic kidney disease, thus improving quality of life and symptoms.
- Trial name
- PD-HF (NCT02708407)
- Testing
- Peritoneal Dialysis
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Cancer of Colon
Psoas Density in Colorectal Cancer
Colorectal cancer (CRC) is the 3rd most common cancer worldwide. In the UK, CRC is the 4th most common cancer accounting for 12% of cancers diagnosed each year with approximately 41,300 new cases diagnosed in 2014.
- Trial name
- NCT04198025
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Nottingham
Asthma, COPD
A Comparison of Two Nebulisers for Sputum Induction
Sputum induction is considered a relatively non-invasive, reliable procedure, which can be utilised to characterise the inflammatory profile of the airways. However, the procedure can be slightly uncomfortable for patients.
- Trial name
- FLAME (NCT04182009)
- Testing
- Omron NE-U17 Ultrasonic nebuliser, Akita Jet Inhalation System
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Nottingham
Motility Disorder of Intestine, Ondansetron
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
This is a double-blind, two period, two treatment crossover trial of ondansetron verses placebo studying the effects of ondansetron in the small and large bowel, specifically its effects on the amount of water in the gut…
- Conditions
- Motility Disorder of Intestine, Ondansetron, Small Bowel Water
- Trial name
- MOLID (NCT03833999)
- Testing
- Ondansetron 8mg, abdominal MRI, Lactulose
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Weight Loss
Effects of Two Weeks of 5:2 Intermittent Energy Restriction on Basal and Postprandial Metabolism
Worldwide, a third of adults were overweight in 2016, and 13% were obese. Excess energy intake results in weight gain. Excess fat increases the risk of disease (eg.
- Trial name
- NCT04138160
- Testing
- 5:2 Intermittent energy restriction, Continuous energy restriction
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Metabolic Health
Effects of Two-weeks of Time Restricted Feeding on Basal and Postprandial Metabolism in Healthy Men
In the modern era, food access is widely available and it is not uncommon for the time between breakfast and a late night snack to exceed 14 hours.
- Trial name
- TRF (NCT03969745)
- Testing
- Time restricted feeding, Caloric restriction
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Burns, Smoke Inhalation Injury
Helping Children's Centres to Enhance Home Safety
Many children have accidents, some are very serious and they are a major cause of death in children aged 1-4 years. Many accidents are preventable This study aims to find out the best way to help Children's Centres to provide…
- Trial name
- NCT01452191
- Testing
- Injury Prevention Briefing Plus facilitation, Injury Prevention Briefing
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Pregnancy, Smoking
MiQuit Trial: Tailored Text Messages for Pregnant Women
The overall aim of the study is to estimate the likely impact of the MiQuit text message based smoking cessation service for pregnant smokers and to establish robust estimates for the key factors which would be required in order…
- Trial name
- MiQuit (NCT02043509)
- Testing
- MiQuit
- Where
- 15 sites in United Kingdom
- Volunteers
- 407 people
- Sponsor
- University of Nottingham
Crohn's Disease
Eating Behaviour in Crohn's Disease
Food intake is mainly controlled through interactions between the gut and brain (the homeostatic control) and through our environment, with food exposure, mood and past experiences (the hedonic control) playing a major role.
- Trial name
- NCT02379117
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Nottingham