Clinical trials: sponsored by University of Nottingham
Depression, Anxiety
RCT of the Effectiveness of Big White Wall Compared to Other Online Support
A randomised controlled trial to compare the effect on wellbeing of an online peer review website (Big White Wall) compared to freely available online information (NHS Moodzone) for people with depression and anxiety.
- Trial name
- REBOOT (NCT02902159)
- Testing
- BWW Online Peer Support, NHS Moodzone Online Information
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,200 people
- Sponsor
- University of Nottingham
Depression and Self-Harm
RCT of the Clinical and Cost Effectiveness of Cognitive Behaviour Therapy (CBT) Delivered Remotely Versus Treatment as Usual in Adolescents and Young Adults With Depression Who Repeatedly Self-harm
A randomized controlled trial to test the whether remote delivery of cognitive based therapy (CBT) is clinically and cost effective when compared to treatment as usual in adolescents and young adults with depression who self-harm.
- Trial name
- eDASH (NCT02377011)
- Testing
- Problem solving cognitive behaviour therapy (PS CBT)
- Where
- 4 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Nottingham
Frequent Utilisers of Urgent Medical Care Who Have High Health Anxiety
Helping Urgent Care Users Cope With Distress About Physical Complaints
To determine the cost and clinical effectiveness of offering 6-10 sessions of remotely delivered cognitive behaviour therapy (CBT) via video calling or over the telephone for health anxiety in repeated utilisers of…
- Trial name
- NCT02298036
- Testing
- (Remote) Cognitive Behaviour Therapy
- Where
- 4 sites in United Kingdom
- Volunteers
- 156 people
- Sponsor
- University of Nottingham
Carer Stress Syndrome
Effectiveness of Acceptance and Commitment Therapy Self-Help for Carers of People With Multiple Sclerosis
This is a feasibility study to evaluate whether it is possible to conduct a larger study to evaluate whether providing psychological support to carers of people with MS is effective in reducing carer strain.
- Trial name
- NCT03077971
- Testing
- ACT Self-Help, ACT Self-Help with Telephone Support
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Recurrent Pterygium
Strategies for Management of Recurrent Pterygium
Pterygium is a common eye disease. Its mechanism remains unknown but studies suggest that it is related to exposure to ultraviolet rays and ocular dryness.
- Trial name
- REPEAT (NCT02530801)
- Testing
- Bevacizumab, 5 fluorouracil
- Volunteers
- 25 people
- Sponsor
- University of Nottingham
Healthy
Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training
The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at…
- Trial name
- NCT02142855
- Testing
- Concentric Exercise Training, Eccentric Exercise Training
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn Disease
Magnetic Resonance Imaging of Motility in Crohn's 2
Crohn's disease (CD) is becoming more common. One of the main features of this disease is weight loss and malnutrition with symptoms such as tummy aches and bloating.
- Trial name
- MIC2 (NCT03052465)
- Testing
- Test soup meal feeding intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Healthy
Millets and Oats MRI
Breakfast porridges made from milled grains are commonly eaten worldwide. Traditionally different grains are used in different countries.
- Trial name
- MOM (NCT03068039)
- Testing
- Oats breakfast porridge, Pearl (bajra) breakfast porridge
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Preterm Birth
Preterm Infant Transport Stress (PremiTranS) Study
This is an observational pilot study to quantify the amount of vibration, noise, physiological and biochemical instability that premature babies are exposed to during inter-hospital transport.
- Trial name
- PremiTranS (NCT01851668)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Knee Pain Phenotypes in the Community Study
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over.
- Trial name
- NCT02098070
- Where
- United Kingdom
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Health Behavior, Diabetes Mellitus, Type 2
The Effectiveness of Diabetes Self-Management Education Program Based on Behavioural Change Theory
In this study, researchers will test the effectiveness of a self-management education programme, on self-management behaviours of patients with type two diabetes.
- Trial name
- IMB-DSME (NCT02699541)
- Testing
- Diabetes Self-Management Education
- Where
- 2 sites in Jordan
- Volunteers
- 151 people
- Sponsor
- University of Nottingham
Preoperative Care, Colorectal Neoplasms
Assessing The Effectiveness of a Preoperative High Intensity Interval Training Programme In Older Colorectal Cancer Patients
The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.
- Conditions
- Preoperative Care, Colorectal Neoplasms, Aged, Exercise
- Trial name
- HITCa (NCT02188342)
- Testing
- HIT
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome, Post Infective Bowel Dysfunction
Saccharomyces Cerevisiae CNCM I-3856 Treatment in Irritable Bowel Syndrome With Diarrhea (IBS-D) and Post Infective Bowel Dysfunction
Irritable Bowel Syndrome (IBS) is a common condition characterised by abdominal pain or discomfort and altered bowel habit affecting up to 10% of the population.
- Trial name
- NCT00977587
- Testing
- Saccharomyces Cerevisiae CNCM I-3856
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
Cancer, Gastrointestinal Neoplasms
Tamoxifen in Patients With Oesophageal Cancer
Cancer of the gullet (oesophagus) is a lethal disease in which only 15% of patients survive 5 years once diagnosed. It is more common in men than women, and men appear to have a worse prognosis.
- Trial name
- NCT02513849
- Testing
- Tamoxifen
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Breast Cancer
Hybrid Gamma Camera in Breast Surgery
A novel hand held hybrid optical-gamma camera (hereinafter referred to as the "camera") has been developed and can be used to image radiotracer distribution at the patient bedside.
- Trial name
- HICAM (NCT02621099)
- Testing
- Hybrid optical-gamma imaging
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Stroke
Early Electrical Stimulation to Prevent Complications in the Arm Post-stroke - a Feasibility Study
Stroke is the largest cause of adult disability in the United Kingdom. Loss of hand function, muscle weakness, pain, and joint deformities are persistent and disabling problems for nearly half of all stroke survivors.
- Trial name
- ESCAPS (NCT02324634)
- Testing
- NeuroTrac Rehab dual channel device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Campylobacter Infections, Irritable Bowel Syndrome
Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota
The principal research objective is to determine the impact of antibiotic use on the risk of developing long term bowel symptoms after infection with the germ Campylobacter.
- Trial name
- CERAMIC (NCT02040922)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Nottingham
Invasive Breast Cancer
AKT Inhibitor in Oestrogen Positive Breast Cancer
To compare the effect of four and a half days treatment of a range of doses of AZD5363 on selected markers of the AKT pathway and anti-proliferation compared with placebo in oestrogen receptor positive breast cancers.
- Trial name
- STAKT (NCT02077569)
- Testing
- AZD5363
- Where
- 11 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Nottingham
Long-Term Care, Palliative Care
Decision Making and Future Planning for Children With Complex Illness
The population of children with life-limiting illnesses (LLI) in England is increasing and there is growing need to improve the quality of children's palliative care.
- Trial name
- NCT02579577
- Testing
- Observation, Interviews, Medical notes review
- Where
- 3 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham