Clinical trials: sponsored by University of Nottingham
Asthma
Low Exhaled NO and ICS in Suspected Asthma
The purpose of this study is to determine whether a low exhaled nitric oxide reading (<27ppb) is a good predictor of a negative response to inhaled steroid treatment for patients with symptoms suggestive of asthma.
- Trial name
- LowNO (NCT02771717)
- Testing
- Budesonide (Pulmicort)
- Volunteers
- 165 people
- Sponsor
- University of Nottingham
Myopathy
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy
A major contributor to frailty and immobility in the elderly is the age related loss of muscle mass (sarcopenia). Cardiovascular disease (CVD) is the leading cause of mortality in the elderly, with high blood cholesterol and…
- Trial name
- NCT01047163
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cystic Fibrosis, Sensorineural Hearing Loss
Evaluation of the High Frequency Digit Triplet Test in Cystic Fibrosis
The purpose of this study is to find out whether the High Frequency Digit Triplet test can be used to screen patients with cystic fibrosis for hearing loss in conditions of health and pulmonary exacerbation.
- Trial name
- 3D-CF (NCT02252601)
- Testing
- HFDT test, Pure tone Audiogram
- Where
- 3 sites in United Kingdom
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Intrauterine Pregnancy, Ectopic Pregnancy
Pregnancies of Uncertain Location or Viability Research
Study to determine the diagnostic accuracy of the double decidual sac sign to predict an intrauterine pregnancy prior to ultrasonographic visualisation of embryonic contents using modern ultrasound technology.
- Trial name
- PULoVR (NCT02700789)
- Testing
- Transvaginal ultrasound scan
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- University of Nottingham
Oesophageal Adenocarcinoma
Effects of Chemotherapy on Muscle Mass and Exercise Performance in Patients With Oesophageal Cancer.
Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the…
- Trial name
- Oeso-Chemo (NCT01742312)
- Testing
- DEXA scan, Muscle biopsy, cardio-pulmonary exercise testing (CPEX)
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Nottingham
Chronic Cough
An Open Label Trial of Azithromycin in Chronic Productive Cough
We have noticed a group of patients presenting with a longstanding wet cough which has often been treated as asthma. The cough is productive of sputum which frequently contains bacteria, but does not resolve with standard…
- Trial name
- AZCC (NCT02196493)
- Testing
- Azithromycin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Congenital Uterine Anomalies
Prevalence of Congenital Uterine Malformations
Aims: We plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups.
- Trial name
- PUMA (NCT01487616)
- Where
- United Kingdom
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
A RCT of Telephone-supported ACT in MS
This study will investigate the feasibility of running a randomised controlled trial (RCT) of a psychotherapy called "Acceptance and Commitment Therapy (ACT)", delivered in a self-help format with additional telephone support…
- Trial name
- NCT02596633
- Testing
- Telephone-support Acceptance and Commitment Therapy (ACT)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Pancreatitis
Pancreatic Perfusion Using Secretin and MRI
The purpose of this study is to assess pancreatic perfusion in patients with chronic pancreatitis at rest and after secretin stimulation and compare this to published data on pancreatic perfusion in normal subjects.
- Trial name
- NCT02458118
- Testing
- Secretin
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Asthma
Characterising the Microbiota in Asthma
Previous work has determined that there are significant differences in the communities of bacteria found in the airways of asthmatic patients compared to those found in the airways of healthy people.
- Trial name
- MIA (NCT02671773)
- Testing
- Inhaled corticosteroid dose/type
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis, Relapsing-Remitting
Worms for Immune Regulation of Multiple Sclerosis
The purpose of this study is to determine whether people with MS who are exposed to a small number of hookworms will have less inflammation and less MS disease activity.
- Trial name
- WIRMS (NCT01470521)
- Testing
- Hookworm larvae
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Nottingham
Stroke
A Low Cost Virtual Reality System for Home Based Rehabilitation of the Upper Limb Following Stroke
Stroke is the third most common cause of mortality and the leading cause of long term disability worldwide with over 900,000 people living in England who have had a stroke.
- Trial name
- WiiSTAR (NCT02637791)
- Testing
- Virtual glove
- Volunteers
- 27 people
- Sponsor
- University of Nottingham
Behaviour
Effects of Omega-3 Fatty Acids Supplementation on Brain and Behaviour in Healthy Children.
Currently, there is considerable interest in the possibility that dietary supplementation with fatty acids, mostly omega-3 fatty acids, will have potential benefits for brain development.
- Trial name
- NCT02346773
- Testing
- ω-3 LC-PUFA
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Application of Deuterated Water (D2O) to Define the Etiology of Musculoskeletal Decline in Ageing and the Efficacy of Nutritional Supplementation
Maintaining muscle mass and function is important in healthy ageing to maintain quality of life. Loss of muscle mass is major problem, as beyond the age ~50, muscle mass declines by ~1-2% a year.
- Trial name
- NCT02505438
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Infertility, Ovarian Aging
Dehydroepiandrosterone (DHEA) Intervention To Treat Ovarian Aging
To test the hypothesis that supplementation of DHEA for at least twelve weeks prior to and during ovarian stimulation increases oocyte quantity (number of oocytes retrieved) and oocyte quality (clinical pregnancy rates and…
- Conditions
- Infertility, Ovarian Aging, Diminished Ovarian Reserve (DOR), Predicted Poor-responders
- Trial name
- DITTO (NCT01572025)
- Testing
- Dehydroepiandrosterone
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Chronic Unipolar Depressive Disorder
Trial of the Clinical and Cost Effectiveness of a Specialist Expert Mood Disorder Team for Refractory Unipolar Depressive Disorder
The purpose of this study is determine whether a specialised mood disorder service, which offers tailored psychological and pharmacological treatment, is more effective in the treatment of chronic unipolar depressive disorder…
- Trial name
- NCT01047124
- Testing
- Specialist Mood Disorders Team
- Where
- 3 sites in United Kingdom
- Volunteers
- 219 people
- Sponsor
- University of Nottingham
Dementia, Confusion
Trial of a Medical and Mental Health Unit for Older People
This research is an evaluation of the MMHU compared to standard care. Patients who are over 65 and 'confused' at admission will be randomly allocated to the MMHU or standard care.
- Conditions
- Dementia, Confusion, Cognitive Impairment, Delirium
- Trial name
- TEAM (NCT01136148)
- Testing
- A medical and mental health unit
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Nottingham
Pain, Surgical Wound
Preemptive Paracetamol for Postoperative Pain
The purpose of this study is to test whether a dose of paracetamol given before surgical incision is more effective at reducing postoperative pain and analgesic consumption in cervical spine surgery versus a dose given at the end…
- Trial name
- PPPP (NCT02425254)
- Testing
- Intravenous paracetamol, Intravenous saline 0.9%
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Stroke
Assessment of GRASP Medical Device to Improve Arm Coordination After Stroke
Assessment of a custom made grasp device in the rehabilitation of stroke victims.
- Trial name
- NCT01134796
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes
Improving Glycaemic Control With L-carnitine
A characteristic of Type 2 diabetes is a high blood glucose level, which is partly caused by the inability of insulin to stimulate glucose uptake into our muscles (insulin resistance).
- Trial name
- NCT02197299
- Testing
- L-carnitine
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Nottingham