Clinical trials: sponsored by University of Nottingham
Quality of Life
The Dementia Quality of Life Scale for Older Family Carers (DQoL-OC) Study
The purpose of this research is to develop the "DQoL-OC", a unique questionnaire to evaluate the quality of life of people aged 60 or above providing care for a family member with Alzheimer's disease or other related dementia at…
- Trial name
- DQoL-OC (NCT02463734)
- Where
- 14 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Lymphangioleiomyomatosis, Tuberous Sclerosis
Doxycycline In Lymphangioleiomyomatosis (LAM)
The purpose of the study is to test if the drug doxycycline is effective in slowing the progression of lung disease in LAM. Lymphangioleiomyomatosis (LAM) is a rare lung disease which affects young women.
- Trial name
- NCT00989742
- Testing
- Doxycycline
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Nottingham
Motor Development of Premature Infants
Helping Our Premature Infants ON to Better Motor Skills (HOP-ON)
Infants born very premature have biological risk factors for later developmental coordination disorder. Parental stereotyping of infants as fragile and other environmental factors, such as spending long periods laying on their…
- Trial name
- HOP-ON (NCT01281358)
- Testing
- HOP-ON, SMILES
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Nottingham
Prone Position, Cardiac Output
Effect of Prone Position on Liver Blood Flow and Function
Recent occurrence of significant post-operative liver impairment at Nottingham University Hospitals NHS Trust has prompted investigation into whether interaction between general anaesthesia and prone positioning (lying face down)…
- Conditions
- Prone Position, Cardiac Output, Liver Circulation
- Trial name
- PLiF (NCT01781260)
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
Single Test to ARrive at MS Diagnosis. Using a Single MRI Brain Scan to Help Diagnose Multiple Sclerosis
This is a pilot study (a small scale study testing procedures so that the investigators can apply this to a larger scale study).
- Trial name
- STAR-MS (NCT02485223)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Corneal Neovascularisation
Strategies for Management of Corneal Neovascularisation
The cornea is the transparent window of the eye, which allows light to enter into the eye and also contributes to the focusing of the light rays.
- Trial name
- NCT02594423
- Testing
- Fine Needle Diathermy, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Psychological Distress, Haematopoietic Stem Cell Transplantation
Psychological Intervention for Distress During HSCT
This Phase II trial aims to evaluate a new psychological intervention to alleviate distress during haematopoietic stem cell transplantation (HSCT) together with examining feasibility.
- Conditions
- Psychological Distress, Haematopoietic Stem Cell Transplantation, Bone Marrow Transplantation
- Trial name
- NCT02212236
- Testing
- Psychological preparation
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Healthy
Effects of Bread Gluten Content on Gastrointestinal Volumes
The investigators will apply non invasive Magnetic Resonance Imaging (MRI) techniques developed in Nottingham to evaluate the gastric emptying, small bowel water content, colonic gas and volumes in healthy volunteers eating three…
- Trial name
- EGG (NCT02104115)
- Testing
- MRI scanners, VAS Symptom scores
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Interval Training, Pre Operative Exercise
HIT in the Healthy Elderly Population
It is widely known that exercise improves general fitness and that fitter patients recover more easily from illness and surgery.
- Conditions
- Interval Training, Pre Operative Exercise, Prehabilitation, Elderly
- Trial name
- HIT (NCT02167191)
- Testing
- HIT
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle, Skeletal
Protein Ingestion and Muscle Carnitine Uptake
The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine…
- Trial name
- NCT02535897
- Testing
- Flavoured water, Flavoured water + carbohydrate, Flavoured water + carbohydrate + protein
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 1 Diabetes Mellitus, Physical Activity
Physical Activity in Children With Type 1 Diabetes Study
This study aims to test the feasibility of a physical activity intervention called the Steps To Active Kids (STAK) programme in children aged 9 - 11 years with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT02144337
- Testing
- Steps To Active Kids (STAK) programme
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Nottingham
Alcoholic Liver Diseases, Decompensated Cirrhosis
Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease
Fibroscan is a non invasive imaging investigation which measures liver stiffness, known to correlate well with liver scarring and cirrhosis on liver biopsy.
- Trial name
- BANDED (NCT01701687)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Healthy
The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year.
- Trial name
- NCT02152839
- Testing
- Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cystic Fibrosis
Circadian Rhythm In Tobramycin Elimination In Cystic Fibrosis
Cystic fibrosis is the most common inherited life limiting condition which affects children. Patients with it develop lung infections which become difficult to clear, and damage the lungs.
- Trial name
- CRITIC (NCT01207245)
- Testing
- Tobramycin time of administration
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Nottingham
Insulin Resistance
Skeletal Muscle Wasting and Insulin Resistance Following Surgical Stress
Background: Skeletal muscle wasting or decrease in muscle mass occurs as a result of alteration in the body's mechanisms to make or break muscle protein.
- Trial name
- SIRSS (NCT01134809)
- Testing
- Major abdominal surgery
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Healthy
Study of Muscle Repair Following Exercise in Young and Elderly People
The aim of this study is to understand how healthy muscle repairs in response to eccentric exercise by evaluating functional, metabolic and molecular measures.
- Trial name
- MDS (NCT02174692)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma, Pulmonary Disease, Chronic Obstructive
Understanding and Appraising the New Medicine Service in England
About 25% medicines prescribed for long term conditions are not taken as directed, and approximately 15% people receiving a new medicine take few, if any, doses.
- Conditions
- Asthma, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NMS (NCT01635361)
- Testing
- New Medicine Service
- Where
- 4 sites in United Kingdom
- Volunteers
- 504 people
- Sponsor
- University of Nottingham
Stroke, Acute Coronary Syndrome
Factors Associated With Perioperative Outcomes in Non-emergency Surgery
This epidemiological study investigates the association of recent stroke, acute coronary syndrome or pneumonia and adverse perioperative outcomes following elective non-cardiac and cardiac surgery using routinely collected UK…
- Conditions
- Stroke, Acute Coronary Syndrome, Pneumonia
- Trial name
- NCT02455492
- Testing
- stroke or myocardial infarction or pneumonia
- Volunteers
- 266,436 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
The Effect of the Low FODMAP Diet and Dietary Oligofructose on Gastrointestinal Form, Function and Microbiota
Some carbohydrates, complex sugars, which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- FOG (NCT02259465)
- Testing
- low FODMAP diet, Oligofructose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Patients Undergoing Open Resection of Colorectal Tumours
Vascular Changes During Colorectal Surgery
The purpose of this study is to investigate whether increases in the blood flow from the heart (the cardiac output), induced by the administration of intravenous fluids, lead to an increase in the blood flow to the vital organs…
- Trial name
- MaMiFlo (NCT02136277)
- Testing
- Hartmann's solution
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham