Clinical trials: sponsored by University of Nottingham
Influenza, Human
Evaluating Modes of Influenza Transmission
The ways in which influenza is transmitted between people are uncertain; for example, we do not know if large droplets or fine particles (aerosols) matter most; both are produced by coughing and sneezing.
- Trial name
- EMIT (NCT01710111)
- Testing
- Intervention Recipients Face Shield
- Where
- United Kingdom
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Portal Hypertension
MRI in Portal Hypertension
Death from chronic liver disease has doubled in the UK over the last decade. This is largely due to the rise in liver disease from excess alcohol consumption, obesity related fatty liver disease and hepatitis B \& C infections.
- Trial name
- MRQuee (NCT01756859)
- Testing
- MRI Scan
- Where
- 2 sites in United Kingdom
- Volunteers
- 49 people
- Sponsor
- University of Nottingham
Vitiligo
HI-Light Pilot Trial for Vitiligo: Hand Held NB-UVB for Early or Focal Vitiligo at Home
This study is a small pilot randomised controlled trial (RCT) comparing hand-held NB-UVB light devices with placebo devices. These devices will be used by the participants to treat their vitiligo at home for a period of four…
- Trial name
- HI-Light (NCT01478945)
- Testing
- 311 nm NB-UVB light
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Nottingham
Obesity
The Effects of Consuming Whey Protein Polydextrose Snacks on Appetite and Energy Intake
Developing functional foods that enhance satiety may be beneficial to individuals to help manage body weight. We have previously shown that consuming a mid-morning liquid preload with increasing proportion of energy derived from…
- Trial name
- NCT01927926
- Testing
- Whey-protein & polydextrose snack, Control snack
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
240 mL Water Drink Study
The GI MRI Research group at the University of Nottingham has been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the gastrointestinal tract.
- Trial name
- NCT01792453
- Testing
- Spring water
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
Investigation of GM Pathology Using Ultra High Field (7T) MRI Scanner
Magnetization transfer imaging is a magnetic resonance technique that has been used over the last few years, and known for its ability to detect abnormalities that can be difficult to detect by conventional MRI techniques.
- Trial name
- NCT01805986
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Enteral Feeding, Nasogastric Feeding
Effects of Bolus and Continuous Nasogastric Feeding on Small Bowel Water Content and Blood Flow
Following surgery some patients are unable to swallow. For those requiring nutritional support a tube is sometimes passed through the nose into the stomach to provide feeding.
- Conditions
- Enteral Feeding, Nasogastric Feeding, Diarrhoea
- Trial name
- NCT01557673
- Testing
- NG bolus feeding over 5 min, Continuous NG feeding over 4 h
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Renal Failure
Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure
The purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.
- Trial name
- NCT01135979
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Healthy
Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption
The investigators have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the small bowel. Building on those studies the investigators want to study, in healthy volunteers, the effects of…
- Trial name
- NCT01763281
- Testing
- CRH
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis
Nottingham Osteoarthritis Biomarker Study 2011
Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that…
- Trial name
- NCT01495455
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parturition, Natural Childbirth
Effects of Aromatherapy on Childbirth
Aromatherapy is a form of complementary medicine that uses scented materials known as essential oils for the purpose of affecting a person's health or mood.
- Conditions
- Parturition, Natural Childbirth, Labor Pain
- Trial name
- NCT01051726
- Testing
- Aromatherapy oil, None essential oil
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Effects of FODMAPs on Small Bowel Water Content: an MRI Study
Some carbohydrates, particularly fructose, the sugar found in fruit and bread may cause bloating, pain and erratic bowel habits (diarrhoea and constipation) particularly in patients suffering from the irritable bowel syndrome…
- Trial name
- FODMAPs (NCT01459406)
- Testing
- Glucose, Fructose, Fructan
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
MRI Study of Stomach Volumes and Satiety
The GI MRI Research group at the University of Nottingham has been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the gastrointestinal tract.
- Trial name
- NCT01690182
- Testing
- Study test meal 1, Study test meal 2, Study test meal 3
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Polycystic Ovary Syndrome
Reflexology's Effect on Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome (PCOS) is very common, affecting approximately 5% of women of reproductive age, and impacts not only on quality of life, but also has long-term health consequences for many sufferers, such as increased…
- Trial name
- REPOS (NCT00744510)
- Testing
- Reflexology
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Nottingham
Colorectal Cancer
Effect of EPA on Aerobic Performance, Muscle, and Quality of Life in Colorectal Cancer Surgery Patients
Primary Aim is to test the Hypothesis: Nutritional supplementation with 960mg EPA three times a day positively affects muscle function and mass (assessed by muscle biopsies, assays of cellular aerobic function and DEXA scan) and…
- Trial name
- EPA-colo (NCT01320319)
- Testing
- Experimental: Nutritional Supplementation with EPA
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Nottingham
Polycystic Ovary Syndrome
Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study
Polycystic Ovary Syndrome (PCOS) is very common, affecting approximately 5% of women of reproductive age, and impacts not only on quality of life, but also has long-term health consequences for many sufferers, such as increased…
- Trial name
- REPOS (NCT00746148)
- Testing
- Reflexology
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Nottingham
Regional Blood Flow
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance in Older People
With age, muscles tend to waste at 0.5-1% per year, so that an 80 year old may have only 70% of the muscle possessed at 50. Muscle loss makes it harder to carry out tasks that require strength, keep the body balanced and continue…
- Trial name
- Dunhill01 (NCT01734616)
- Testing
- Old Exercise, Old Acute Cocoa, Old 7 Day Cocoa
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Tobacco Smoking
Trial Comparing Different Methods of Support With Stopping Smoking (PORTSSS/Stop Together Trial)
This study shall determine whether or not proactive telephone support for smoking cessation delivered to quitline callers is more effective than standard 'reactive' provision and whether or not the offer of a voucher for a cost…
- Trial name
- PORTSSS (NCT00775944)
- Testing
- Proactive telephone support, Reactive (standard) telephone support, Offer of voucher for cost-free Nicotine Replacement Therapy
- Where
- United Kingdom
- Volunteers
- 2,591 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obstructive Jaundice, Disease as Reason for ERCP
Immune Function in Patients With Obstructive Jaundice
Patients with obstructive jaundice (OJ) often require surgical, endoscopic or radiological interventions to facilitate biliary drainage and relieve jaundice.
- Conditions
- Obstructive Jaundice, Disease as Reason for ERCP, Immune Dysfunction, Immune Tolerance
- Trial name
- NCT01367821
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham