Clinical trials: sponsored by University of Nottingham
Influenza
Evaluating Modes of Influenza Transmission Between Humans
Most countries of the world, including the USA are making preparations for a possible influenza pandemic. Such an event will constitute a global public health emergency, but it is impossible to predict when this will happen.
- Trial name
- NCT01150149
- Testing
- No face touch, Surgical face mask, Surgical face mask + no face touch
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
Novel (H1N1) Influenza
Virus Shedding and Environmental Deposition of a Novel Influenza Virus
An influenza pandemic has recently been declared, involving the novel A(H1N1) 'swine flu' virus. This has spread to almost 100 countries worldwide in less than two months, causing widespread disease so far in Mexico, USA and…
- Trial name
- NCT01046734
- Where
- 3 sites in United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
Liver Fibrosis
Magnetic Resonance Imaging in the Evaluation of Liver Fibrosis
The main purpose of this pilot study is to evaluate non-invasive magnetic resonance imaging (MRI) techniques in the detection and grading of liver fibrosis, so that the investigators can reduce the need of invasive techniques…
- Trial name
- Mrker (NCT01572064)
- Testing
- Blood sample, MRI Scan
- Where
- United Kingdom
- Volunteers
- 134 people
- Sponsor
- University of Nottingham
Diabetes
Effect of Flavanol-rich Cocoa on Peripheral and Cerebral Blood Flow in Type 2 Diabetes
Cocoa flavanols form part of the family of chemicals (also found in red wine and tea) which have aroused interest due to population studies suggesting that diets high in these substances might reduce risks of heart disease.
- Trial name
- NCT01654172
- Testing
- High Flavanol Cocoa, Low Flavanol Cocoa
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Nottingham
Cellulitis/Erysipelas of the Leg
RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg
To assess whether a period of prophylactic penicillin after an episode of cellulitis of the leg reduces the risk of repeat episodes. Participants are randomised to receive 12 months of prophylaxis (penicillin VK 250mg b.d.
- Trial name
- PATCH1 (NCT00552799)
- Testing
- Penicillin VK
- Where
- 25 sites in Ireland, United Kingdom
- Volunteers
- 274 people
- Sponsor
- University of Nottingham
Stroke
The Efficacy of Nitric Oxide in Stroke (ENOS) Trial
Nitric oxide is a multimodal candidate treatment for acute stroke having a number of properties which may be beneficial in acute stroke, including lowering blood pressure, causing cerebral vasodilation, and improving central and…
- Trial name
- ENOS (NCT00989716)
- Testing
- Transdermal glyceryl trinitrate patch, Pre-stroke antihypertensives
- Where
- United Kingdom
- Volunteers
- 3,500 people
- Sponsor
- University of Nottingham
Hepatic Fatty Acid Metabolism, Systemic Insulin Resistance
The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
Dietary consumption of fructose has increased by nearly 50% since 1960. A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet.
- Conditions
- Hepatic Fatty Acid Metabolism, Systemic Insulin Resistance, Oxidative Stress, Cardiovascular Status
- Trial name
- NCT01050140
- Testing
- high sugar diet
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Non-alcoholic Fatty Liver Disease
The Effect of n-3 Polyunsaturated Fatty Acid Supplements in Patients With Non-alcoholic Fatty Liver Disease
The principal purpose of this study is to determine whether increased intakes of n-3 polyunsaturated (omega-3) fatty acids will reduce the amount of fat stored in the liver in patients with non-alcoholic fatty liver disease.
- Trial name
- NCT00819338
- Testing
- Efamax
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Nottingham
Cerebral Palsy
Targeted Hip Strength Training in Children With Cerebral Palsy (CP)
This study's main aim is to look at targeted strength training for muscles at the hips. Specifically to consider whether targeted strength training not only effects strength of the specific muscles but also ability to stand on…
- Trial name
- NCT01633736
- Testing
- Usual care plus progresive resistance training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Diverticulosis, Colonic
Mechanistic Randomized Controlled Trial (RCT) of Mesalazine in Symptomatic Diverticular Disease
Diverticulosis (bulges in the bowel wall) affects two third of the elderly population in the UK. Diverticular disease and its complications are responsible for 68000 hospital admissions and 2000 deaths per year.
- Trial name
- NCT00663247
- Testing
- Mesalazine
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Multiple Sclerosis
Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis.
The aim of the study is to determine whether controlled infection with a clinically safe number of larvae of hookworm results in an immune response that is protective in relapsing MS.
- Trial name
- WIRMS-1 (NCT00630383)
- Testing
- Live Hookworm Larvae, Histamine
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome With Diarrhoea
Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D)
Irritable bowel syndrome is a common condition affecting 1 in 10 of the population. About a third of these suffer from diarrhoea, which severely impairs their quality of life.
- Trial name
- NCT00745004
- Testing
- Ondansetron
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Nottingham
Post-operative Pain, Postoperative Nausea
Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
Keyhole surgery for bowel disease has brought great benefits, enabling patients to recover quicker from surgery and so return to normal activities.
- Conditions
- Post-operative Pain, Postoperative Nausea, Postoperative Complications
- Trial name
- NCT00830089
- Testing
- Levobupivicaine 0.25%
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Nottingham
Laparoscopic Cholecystectomy
Responses to Colloid Infusions
In situations such as dehydration, illness and surgery, fluid 'drips' are given to patients to keep them hydrated. Different fluids stay in the circulation for different lengths of time.
- Trial name
- NCT00868062
- Testing
- Succinylated gelatine, 40g/L, (Gelofusine - B Braun)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Pancreatitis
Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers
Alterations in pancreatic blood have been implicated in pancreatic inflammation and pain. Several modalities have been used to assess pancreatic blood flow although some of these methods are invasive, use ionising radiation or…
- Trial name
- NCT01452217
- Testing
- Secretin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Fluid Overload, Water Electrolyte Imbalance
The Effect of Crystalloids and Colloids on Visceral Blood Flow
Patients often require fluid replacement during and after an operation. This is usually given through veins in the arm using an intravenous cannula and doctors have traditionally used fluid containing sodium chloride (saline).
- Conditions
- Fluid Overload, Water Electrolyte Imbalance, Acid Base Imbalance
- Trial name
- NCT01087853
- Testing
- Crystalloid, Colloid
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Depression
Promoting Wellbeing for Women With Depression: A Pragmatic Randomised Controlled Trial (RCT) of an Exercise Programme
The investigators want to find out if their specially designed exercise programme will be more successful at helping women with depression to feel better than a basic programme will, by measuring the effect the programme has on…
- Trial name
- NCT00546221
- Testing
- Psychosocial support exercise programme, Prescribed exercise
- Where
- 3 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- University of Nottingham
Low Back Pain
Working Well With Back Pain (Feasibility RCT of Vocational Rehabilitation)
Back pain has a major impact on people's ability to work. Health professionals need to know how they can best use their limited resources to address the occupational needs of people with chronic low back pain.
- Trial name
- NCT00817882
- Testing
- individually targeted vocational rehabilitation, routine back pain rehabilitation
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Nottingham
Sphincter of Oddi Dysfunction
A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers
The sphincter of Oddi is a circular band of muscle which controls the flow of pancreatic juices and bile into the small intestine.
- Trial name
- NCT01134848
- Testing
- Morphine, Neostigmine, 0.9% saline
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham