Clinical trials: sponsored by University of Nottingham
Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)
The Microbiome in Blood Cancer and HLH
The bacteria and viruses in the bowel (gut microbiota; GM) have powerful effects on the immune system. GM changes are seen in patients with auto-immune diseases, where the immune system attacks normal tissues, and cancer, and for…
- Conditions
- Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Haemophagocytic Lymphohistiocytosis
- Trial name
- NCT06734624
- Where
- United Kingdom
- Volunteers
- 750 people
- Sponsor
- University of Nottingham
Chronic Kidney Disease
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
The purpose of the present study is to investigate the association between the accumulation of advanced glycation end-products (AGE) and adverse outcomes (e.g.
- Trial name
- AGED (NCT02878317)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Nottingham
Chronic Kidney Disease Requiring Chronic Dialysis
Immuno-nutrition Supplementation in Haemodialysis
The purpose of this pilot study is to test if an "immuno-nutrition" supplement can decrease inflammation in people on haemodialysis.
- Trial name
- NCT05700851
- Testing
- Immuno-nutrition supplement
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Nottingham
Multiple Sclerosis
Providing Emotional Support Around the Point of Multiple Sclerosis Diagnosis: PrEliMS 2
Emotional support following Multiple Sclerosis (MS) diagnosis is not part of the current service provision. However, research has identified a need for this as poor adjustment to diagnosis has been linked to higher levels of…
- Trial name
- PrEliMS2 (NCT05225012)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Effect of Chronic Feeding of Inulin And Methylcellulose on Colonic Fermentation
To determine the effect on tolerance and gas production from chronic feeding of fermentable fibre (inulin) incorporated into a gel forming fibre (methylcellulose) compared with placebo (maltodextrin)
- Trial name
- CINNAMON (NCT06551961)
- Testing
- methylcellulose, inulin, maltodextrin
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Inattention, Cognitive Training
RECOGNeyes Gaze-Control Training
RECOGNeyes is a computer game developed by members of the research team to improve attention in people who find it hard to "keep their eyes on the task".
- Conditions
- Inattention, Cognitive Training, Cognitive Control, Oculomotor Dysfunction
- Trial name
- NCT06691646
- Testing
- Gaze-control training game
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Effect of Modified Cellulose on Colonic Fermentation of Inulin
A 3-way randomised cross-over study to test the hypothesis that combining either psyllium or methylcellulose to form a gel incorporating inulin will reduce gas production as compared to inulin given with a placebo, maltodextrin.
- Trial name
- COCOA2 (NCT05911347)
- Testing
- Psyllium, Methylcellulose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Colon, Irritable
Effect of Methylcellulose or Psyllium on Fermentation of inUlin Assessed USing MRI
The challenge is to understand how fibre interacts with whole-gut function to alter colonic fermentation of fermentable oligo-di- and mono-saccharides and polyhydric alcohols (FODMAPs).
- Trial name
- RUFUS (NCT06291272)
- Testing
- Psyllium, Methylcellulose, Inulin
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hearing Voices When No One is Talking
ACT for Older Adults Who Hear Voices (HSCED)
Hearing voices (often referred to as "auditory hallucinations") is a common experience amongst the older adult population (those 65+ years of age) and can be associated with increased psychological distress.
- Trial name
- NCT06420024
- Testing
- Acceptance and Commitment Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Effect of Pre-dosing With Methylcellulose or Psyllium on Colonic Fermentation of Inulin
The aim for this pilot study is to test the hypothesis that pre-dosing with gel-forming dietary fibres (methylcellulose or psyllium) will alter the colonic fermentation of a model fermentable dietary fibre (Inulin) when delivered…
- Trial name
- COCOA3 (NCT06494137)
- Testing
- inulin
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Eating Disorders
tDCS and Emotional Eating
This research investigates the feasibility of undertaking a large, randomised control trial of transcranial direct current stimulation (tDCS) as a treatment modality for managing food cravings and emotional eating.
- Trial name
- NCT06488287
- Testing
- Transcranial direct current stimulation (brain stimulation)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Constipation
MRI Assessment of Mode of Action of Bisacodyl, Multiple Doses
Constipation remains an important unmet medical need. Patients are currently often dissatisfied with treatment, because of lack of predictability of the laxative, side effects (mainly abdominal pain) and perceived decrease of…
- Trial name
- MODEM (NCT04129788)
- Testing
- Bisacodyl 5 milligram
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Constipation
MRI Assessment of Mode of Action of Bisacodyl, Single Dose
Constipation remains an important unmet medical need. Patients are currently often dissatisfied with treatment, because of lack of predictability of the laxative, side effects (mainly abdominal pain) and perceived decrease of…
- Trial name
- MODS (NCT04132661)
- Testing
- Bisacodyl 5 milligram
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Sugar; Blood, High
The Acute Effect of D-allulose Consumption on Postprandial Glycaemia
The rare sugar D-Allulose, when consumed in a drink before eating has been shown to reduce the blood glucose response to high carbohydrate drinks or meals in people who are healthy, or have elevated fasting blood glucose…
- Trial name
- NCT06330636
- Testing
- D-Allulose, Sodium Saccharin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Musculoskeletal Pain, Frailty, Disability
Investigating Musculoskeletal Health and Wellbeing
Background The progression and associations of central and peripheral musculoskeletal pain, frailty, disability and fracture risks are not well known.
- Trial name
- NCT03696134
- Testing
- questionnaire
- Where
- United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- University of Nottingham
Bariatric Surgery Candidate, Obesity
Bariatric Surgery and Exercise Interventions: Effects on Muscle
The purpose of this project is to assess the effects of bariatric surgery on muscle structure and function as well as investigating the feasibility of undertaking an exercise intervention post-surgery.
- Trial name
- NCT05569785
- Testing
- Resistance Exercise Therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Tinnitus
Tinnitus and Cochlear Implants
Objectives of this study are to (1) Determine whether there are meaningful changes in tinnitus outcomes following cochlear implantation in adults with bilateral severe-to-profound hearing loss, (2) Determine the prevalence…
- Trial name
- TICIT (NCT06085885)
- Testing
- Cochlear implant
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis, Knee Pain Chronic
Cognition, Pain and Wellbeing
Osteoarthritis (OA) is the most common form of arthritis and for 4 in 10 people pain from OA is not adequately controlled. The pain experience of people suffering from chronic pain largely depends on their individual perception…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- CPW (NCT04620525)
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel
Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)
To test whether slowing the rate of delivery of inulin with either psyllium or divided dosing of inulin, will reduce colonic gas production as compared to inulin combined with placebo.
- Trial name
- EON (NCT05619341)
- Testing
- psyllium, inulin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Smoking, Smoking Reduction
Preventing Relapse to Smoking Among Prisoners After Release
Prisoners experience huge health inequalities, and their exceptionally high smoking prevalence (five times the national average) contributes significantly to their high mortality.
- Conditions
- Smoking, Smoking Reduction, Electronic Cigarette Use
- Trial name
- PROSPER (NCT04271371)
- Testing
- Not yet developed
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham