Clinical trials: sponsored by University of Nottingham
Inflammatory Disease, Crohn Disease
Monitoring of Inflammatory Conditions
People with inflammatory diseases treated with immune-suppressing medication are recommended to have regular blood-tests to monitor for potential side-effects of this treatment on their blood count, liver and kidneys.
- Conditions
- Inflammatory Disease, Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis
- Trial name
- NCT05458531
- Testing
- Questionnaire, Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Postoperative Delirium
EEG Spectrogram, Brain Vulnerability and POD
An assessment of difference in prespecified processed electroencephalography variables between cognitively intact older surgical patients who develop postoperative delirium compared to those who do not develop postoperative…
- Trial name
- NCT05368272
- Testing
- Processed electroencephalography, Postoperative delirium assessment
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Smoking, Smoking Reduction
Preventing Relapse to Smoking Among Prisoners After Release
Prisoners experience huge health inequalities, and their exceptionally high smoking prevalence (five times the national average) contributes significantly to their high mortality.
- Conditions
- Smoking, Smoking Reduction, Electronic Cigarette Use
- Trial name
- PROSPER (NCT04271371)
- Testing
- Not yet developed
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Intestinal Pseudo-Obstruction
Pseudo-obstruction Assessment With MRI
This study will explore the potential for a standardized MRI scan after a liquid meal to be used in diagnosis of the rare but debilitating chronic intestinal pseudo-obstruction (CIPO).
- Trial name
- POM (NCT04193735)
- Testing
- MRI scans after a liquid meal
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham
Ataxia Telangiectasia
Whole Body MRI for Cancer Surveillance in A-T
Ataxia Telangiectasia (A-T) is an inherited disorder characterised by cerebellar neurodegeneration, immunodeficiency and respiratory disease.
- Trial name
- NCT05252819
- Testing
- Magnetic Resonance Imaging and an optional blood test
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Occupational Stress, Occupational Neurosis
Managing Minds at Work: A Feasibility Pilot Trial
This feasibility pilot cluster RCT aims to pilot and feasibility test an online training toolkit (Managing Minds at Work) for line managers to develop their knowledge and confidence in preventing work-related stress and promoting…
- Conditions
- Occupational Stress, Occupational Neurosis, Mental Health Wellness 1, Absence
- Trial name
- NCT05154019
- Testing
- Managing Minds at Work Online Training
- Where
- United Kingdom
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Tinnitus, Hearing Loss
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss
Tinnitus, the perception of sound in the absence of an external acoustic stimulus. Tinnitus is often perceived inside the head rather than the ear and is a common condition with a prevalence estimated between 10 and 15% in…
- Trial name
- IGNITE (NCT04862572)
- Testing
- MRI scanning
- Where
- 3 sites in United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Kidney Diseases
Establishing a New Ultrasound Technique to Improve Assessment of Chronic Kidney Disease.
Blood flow to the kidneys is important in the development of kidney diseases. Currently we do not have ways of measuring and monitoring kidney blood flow for patients in real-time.
- Trial name
- NCT06159439
- Testing
- Contrast enhanced ultrasound scan, MRI scan
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Rheumatoid Arthritis
Central Aspects of Pain in Rheumatoid Arthritis
This study seeks to measure the psychometric properties of a newly developed Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, and investigate the ability of this questionnaire to measure central mechanisms…
- Trial name
- CAP-RA (NCT04515589)
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Nottingham
Retinopathy of Prematurity
Feasibility of Nurse-led Retinal Imaging for Retinopathy of Prematurity Screening Employing the Optos California
Retinopathy of prematurity (ROP) is a preventable cause of blindness in babies who are born early i.e. premature. Internationally, there is a shortage of skilled ophthalmologists willing and able to screen for ROP.
- Trial name
- N_ORS (NCT06063863)
- Testing
- Nurse led screening with Optos ultra-widefield retinal-imaging device
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Nottingham
Neonatal Disease
A Study of Agreement Between Oxygen Saturation Measured by Two Probes in Infants on the Neonatal Unit
On the neonatal unit in Derby, two types of probes are in routine use: Mindray 520 N and Mindray 521 N. Feedback from parents and staff show that there are concerns that the two probes given very different oxygen saturation…
- Trial name
- Ag-OS (NCT05065229)
- Testing
- Oxygen saturation probe Mindray 520 N and Mindray 521 N
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Traumatic Stress Disorder
Exposing Narrative Exposure Therapy
The main purpose of the study is to further develop an existing measure of autobiographical memory integration (ABMI) to investigate and clarify the ABMI change process specific to narrative exposure therapy (NET).
- Trial name
- NCT05383846
- Testing
- Experimental Narrative Exposure Therapy
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Gastrointestinal Dysfunction
Gastric Emptying Validation Pilot Study (MRI Val)
The primary aim of this study is to assess (in healthy volunteers) the rate at which a glucose drink leaves the stomach by sequential magnetic resonance imaging (MRI) of the stomach contents using a 0.5 tesla upright MRI scanner…
- Trial name
- MRIVal (NCT05765123)
- Testing
- Oral glucose tolerance test
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis, Cognitive Impairment
Feasibility of Neuromodulation With Connectivity-Guided iTBS for Cognitive Impairment in MS
Cognitive difficulties can affect many people who live with multiple sclerosis (MS). These difficulties, such as within thinking, memory, and problem solving, can have an impact on important aspects of an individual's life…
- Trial name
- TMS4MS (NCT04931953)
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Covid19, Muscle Loss
The Impact of Covid-19 on Skeletal Muscle
With the recent worldwide outbreak of the COVID-19 infection and the huge impact it has had upon lives in the UK, it is key to increase knowledge on the impact of the virus on the body.
- Conditions
- Covid19, Muscle Loss, Mitochondrial Alteration
- Trial name
- NCT04756674
- Testing
- No intervetion will be used
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Urinary Incontinence
Physiotherapy to Treat Urinary Incontinence in Athletes
Nearly half of all adult women suffer with Urinary incontinence (UI), this is more common in athletes. UI is considered to be due to weak pelvic floor muscles.
- Trial name
- POsITIve (NCT03986411)
- Testing
- Phase 1: Qualitative interviews: Health care professionals, Phase 2: Physiotherapy for urinary incontinence, Phase 3: Qualitative Interviews: Participants
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Covid19
DYNamic Assessment of Multi Organ Level Dysfunction in Patients Recovering From Covid-19
In this study the investigators are hoping to the find out what changes occur within the body of people recovering from Covid-19 at 5-7 months and 11-13 months following discharge from hospital, compared to healthy controls, and…
- Trial name
- DYNAMOCovid-19 (NCT05060497)
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Familial Breast Cancer
Specialist Recommendation on FBC (Familial Breast Cancer) Chemoprevention Prescribing
Some women are more likely to get breast cancer as it runs in their family, they are at risk of familial breast cancer. There are medications, called chemoprevention, which may lower their risk of developing breast cancer by a…
- Trial name
- FBC (NCT04058418)
- Testing
- Survey Administration
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diabetes Mellitus Type 2 in Obese
VLCD & Adjuvant Exercise Effect in Overweight Diabetic Men
Sarcopenia is defined as the incremental age-related loss of skeletal muscle in humans which generally begins from forty years old.
- Trial name
- VLCDeXDM (NCT04957589)
- Testing
- Very Low Calorie Diet, High Intensity Interval Training
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham