Clinical trials: sponsored by University of Oklahoma
Stroke
Targeted High-definition Transcranial Direct Current Stimulation (HD-tDCS) for Reducing Post-stroke Movement Impairments
Stroke is the leading cause of serious, long-term disability. The emergence of abnormal muscle synergies following a stroke presents a major limitation to the recovery of independent function.
- Trial name
- NCT05174949
- Testing
- Transcranial direct current stimulation (high-definition)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Oklahoma
Healthy
Endothelial Derived Hyperpolarization Factor and Vascular Control
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes.
- Trial name
- NCT05176379
- Testing
- Fluconazole 150 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Alveolar Bone Loss
Mineralized and Partial Demineralized Dentin Graft Compared to FDBA
The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable…
- Trial name
- NCT05311735
- Testing
- Freeze-Dried Bone Allograft control, Mineralized Dentin Graft, Partial-Demineralized Dentin Graft
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Attention Deficit Hyperactivity Disorder
Sensory-Play Based (SenPlay) Intervention for Young Children With or At Risk for ADHD
The purpose of this pilot study is to determine the effects of 15 minutes of sensory-play based (SenPlay) intervention on improving focused attention in developmentally appropriate tasks in young children with or at risk for ADHD.
- Trial name
- NCT05222321
- Testing
- Sensory-Play Based (SenPlay) Intervention, Spontaneous, Free Play
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Laceration of Skin, Anxiety
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for…
- Conditions
- Laceration of Skin, Anxiety, Discharge Time
- Trial name
- NCT05934669
- Testing
- Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Use Disorders, Pregnancy Related
The Oklahoma Parent-Child Assistance Program
The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers.
- Conditions
- Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester
- Trial name
- NCT05534568
- Testing
- Parent-Child Assistance Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Oklahoma
COVID-19, Vaccine Refusal
CATCH-UP Vaccines: Engaged Approaches to Testing in Community/Healthcare Settings for the Underserved (COVID-19)
Oklahoma has high COVID-19 incidence, particularly among underserved minority and rural Oklahomans. Oklahoman's are also reporting SARS-CoV-2 vaccine hesitancy and signs of slowing vaccine uptake, with increased hesitancy among…
- Trial name
- NCT05236270
- Testing
- Text Message, Motivational Interviewing, Electronic Educational Message with Tailored Questions/Prompts
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Atrial Fibrillation
SmartWatch ECG Evaluation Trial I
This is a single-center, non-randomized study to collect validation data for submission to the Food and Drug Administration (FDA) to support a 510(k) device clearance for a smartwatch ECG.
- Trial name
- NCT05942274
- Testing
- We propose to validate these smartwatch ECG functions to support FDA submissions
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Tachycardia, Atrioventricular Nodal Reentry
AV Nodal Reentrant Tachycardia Study
The purpose of this study is to determine/identify what mechanisms/factors are involved with regard to AV nodal reentrant tachycardia.
- Trial name
- AVNRT (NCT00618683)
- Testing
- Cardiac Invasive Electrophysiological Study
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Oklahoma
Cigarette Smoking, Nicotine Dependence
Nicotine Withdrawal and Reward Processing
This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
- Trial name
- NicWith (NCT05041959)
- Testing
- Smoking Abstinence, Ad Lib Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Electronic Cigarette Use
Effects of Social Media Use on Young Adults' E-Cigarette Use
The goal of this clinical trial is to test the effects of social media use on e-cigarette use in young adults who use e-cigarettes.
- Trial name
- NCT06142877
- Testing
- Social Media Use Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Hypothermia
Neonatal Warming to Prevent Hypothermia
Researchers are proposing a pilot randomized controlled trial evaluating the benefit of immediately warming preterm babies using a warming mattress and a plastic wrap, while delaying clamping the umbilical cord at the time of…
- Trial name
- NCT04827394
- Testing
- Neonatal warming mattress, Sterile polyethylene wrap
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Ankle Osteoarthritis
TAR 2 Weeks vs 6 Weeks Post-Operative Weight-Bearing
The Investigators hypothesize that an early 2 week post-operative protocol will have no difference in the successful osseointegration and stability of the total ankle replacement as compared to a delayed 6 week post-operative…
- Trial name
- TAR (NCT04709861)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Ovarian Cancer
Unesbulin in Women With Ovarian Cancer Receiving Neoadjuvant Chemotherapy
This is an open-label Phase Ib dose-escalation study to determine the safety, tolerability, and pharmacokinetics of Unesbulin when combined with and following conventional chemotherapy and as maintenance therapy as a capsule…
- Trial name
- PTC-001 (NCT03206645)
- Testing
- Unesbulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Oklahoma
Obesity, Induction of Labor Affected Fetus / Newborn
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term
Obesity increases the risk of pregnancy complications, including among others puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- APPOINT (NCT03801252)
- Testing
- Cefazolin, Azithromycin
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Inappropriate Sinus Tachycardia
Ablation of Inappropriate Sinus Tachycardia
Hypothesis- Radiofrequency ablation, targeting the sympathetic input of the sinus node identified by 20Hz stimulation at the junction of the superior vena cava and the right atrium, will effectively reduce sinus rate acutely and…
- Trial name
- IST (NCT00584649)
- Testing
- electrophysiology study and radiofrequency ablation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Covid19
Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19
This open label clinical trial is to evaluate two different doses of dexamethasone on the health outcome using World Health Organization ordinal scale at day 28 in hospitalized patients with COVID-19.
- Trial name
- NCT04707534
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Oklahoma
Smoking Cessation
Mobile Contingency Management for Smoking Cessation (R01 Supplement) (PrevailGO)
Smoking prevalence rates are disproportionately high among individuals living below the poverty threshold, those living in rural areas, and Oklahomans.
- Trial name
- NCT03517397
- Testing
- Mobile Contingency Management
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Reliability, Validity
SWAY Mobile Application Assessments in Healthy Adults
SWAY Medical, Inc. (SWAY) has developed a mobile application that assesses balance, functional performance, and cognitive function.
- Conditions
- Reliability, Validity, Normative Data
- Trial name
- NCT05616975
- Testing
- test-retest reliability, construct validity, normative data
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lateral Window Sinus Augmentation
Volumetric Changes and Graft Stability in Lateral Window Sinus Augmentation: A Prospective Clinical Trial
The purpose of this study is to evaluate the stability and volumetric changes of the grafting materials used for lateral window sinus augmentation.
- Trial name
- NCT03639077
- Testing
- Allograft bone alone, Allograft and xenograft mixture
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma