Clinical trials: sponsored by University of Oklahoma
ICU Mortality, ICU Morbidity
Adaptation of a Premorbid Function Scoring System as a Predictor for Intensive Care Unit Mortality
To evaluate whether a premorbid functioning scoring system such as the ECOG system can be adapted to predict ICU morbidity and mortality.
- Trial name
- ECOG (NCT02386254)
- Where
- United States
- Sponsor
- University of Oklahoma
Coronavirus Infection, Disease Prevention
Assessment of N-95 Facemask for Use in COVID-19 Pandemic in Case of Shortage of Personal Protective Equipment
The purpose of this study is to assess the safety and efficiency of an assembled modified mask in protecting health care workers against Coronavirus in case of any personal protective equipment shortage.
- Trial name
- NCT04416919
- Testing
- Assembled mask
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Endometrial Cancer, Papillary Serous
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
The purpose of this study is to determine the feasibility of treatment in patients with high risk endometrial cancer treated by vaginal cuff brachytherapy followed by 3 cycles of dose dense paclitaxel and carboplatin chemotherapy.
- Conditions
- Endometrial Cancer, Papillary Serous, Clear Cell Endometrial Cancer
- Trial name
- NCT03189446
- Testing
- Vaginal Cuff Brachytherapy, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Oklahoma
Diabetic Peripheral Neuropathy
Peripheral Nerve Responses to Focal Vibration and Implications in Pain and Mobility for Patients With Diabetic Peripheral Neuropathy
The purpose of this study is to characterize the changes in peripheral nerve functions (sensory and motor) in patients with diabetic peripheral neuropathy, and examine the relations between the changes in nerve functions and…
- Trial name
- NCT05041816
- Testing
- Focal vibration therapy
- Where
- United States
- Sponsor
- University of Oklahoma
Molluscum Contagiosum
MC RCT - BPO vs Adapalene
Non-blinded randomized controlled trial comparing efficacy of topical benzoyl peroxide 10% (vehicle choice per patient preference: e.g.
- Trial name
- NCT05536882
- Testing
- Benzoyl peroxide, Adapalene Gel
- Where
- United States
- Sponsor
- University of Oklahoma
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Metabolic Pathology of Pediatric NAFLD
Nonalcoholic fatty liver disease (NAFLD) is now the most common liver disease worldwide and affects nearly 40% of obese youth and up to 10% of the general pediatric population.
- Conditions
- Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Obesity
- Trial name
- NCT05430178
- Testing
- Oral sugar tolerance test, De novo lipogenesis test, Gluconeogenesis test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Atrial Fibrillation
Synaptic Plasticity in the Epicardial Ganglionated Plexi
Atrial fibrillation (AF) is the most common arrhythmia and the prevalence increase with age. Autonomic nervous system play a critical role in the initiation and maintenance of AF.
- Trial name
- SNAP-GP (NCT05034419)
- Testing
- Parasym
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Oklahoma
Pain, Chronic, Opioid Use Disorder
Pain and Opioid Management in Older Adults
The extent and depth of the ongoing opioid crisis are well known and many interventions are under way in the United States and other countries to alleviate its devastating impact on individuals and the society.
- Trial name
- RISE-OK (NCT05037682)
- Testing
- Dissemination and Implementation Research
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- University of Oklahoma
Paroxysmal Atrial Fibrillation
Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)
This proposal aims to determine the effects of tVNS on autonomic tone, atrial substrate and neuromodulators in patients with paroxysmal atrial fibrillation (AF), investigate the chronic effects of optimal tVNS on AF burden in…
- Trial name
- NCT05172765
- Testing
- Transcutaneous Electrical Nerve Stimulation Device
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Oklahoma
Arrhythmia
Clinical Validation of the AliveCor Kardia 12L and 6L Devices
AliveCor (www.alivecor.com) has developed an ECG device (KardiaMobile) that interfaces with iOS and Android smartphones and tablets.
- Trial name
- NCT05053243
- Testing
- Kardia 12L
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Hematologic Malignancy
Impact of Palliative Transfusions on Quality of Life in Patients With Blood Cancers on Hospice
The purpose of this pilot research study is to evaluate the effectiveness of blood and platelet transfusions in improving symptoms and quality of life of patients enrolled in hospice.
- Trial name
- PalliaQOL (NCT04454723)
- Testing
- Blood and/or platelet transfusion, Complete blood count (CBC) collection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Arrhythmia
Clinical Validation and Safety of the AC 12L ECG System Against a Standard of Care 12-Lead ECG (AC 12L ECG)
AliveCor (www.alivecor.com) has developed an ECG device (KardiaMobile) that interfaces with iOS and Android smartphones and tablets.
- Trial name
- NCT05617001
- Testing
- Kardia 12L
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Atrial Fibrillation, Heart Failure, Diastolic
The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function
Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory and anti-arrhythmic effects.
- Trial name
- LLT-SPANS (NCT04682704)
- Testing
- Parasym
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Quality of Life
Use of Personal Fitness Device in Adult (> 21 Years Old) Patients With Cystic Fibrosis
Approximately half of the variation in the presentation and disease status of patients with Cystic Fibrosis (CF) is secondary to non-genetic variables.[1] These include household income, compliance with therapy, second hand smoke…
- Trial name
- NCT03122418
- Testing
- Personal Fitness Device
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Oklahoma
Tobacco Cessation, Peripheral Artery Disease
Onsite Tobacco Cessation Treatment for Patients With PAD
Tobacco cessation treatment is needed for individuals with peripheral artery disease (PAD) to improve symptoms, lower cardiovascular risk, and prevent amputation.
- Trial name
- PAD (NCT05469698)
- Testing
- Tobacco Treatment Research Program Standard Care
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Iloprost in Gas Exchange/Pulm Mechanics in Chronic Obstructive Pulmonary Disease (COPD)
The investigators believe that iloprost will improve gas exchange in COPD patients with pulmonary hypertension.
- Trial name
- Iloprost (NCT00561223)
- Testing
- iloprost Inhalation, iloprost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Oklahoma
Cervical Cancer, Endometrial Cancer
Bevacizumab and Rucaparib in Recurrent Carcinoma of the Cervix or Endometrium
This is a phase II study of rucaparib, a small molecule inhibitor poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP), being tested in combination with bevacizumab in patients with recurrent cervical or endometrial…
- Trial name
- Clovis-001 (NCT03476798)
- Testing
- Rucaparib, Bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Oklahoma
Breast Cancer, Head and Neck Cancer
Virtual Reality Software to Reduce Stress in Cancer Patients
The purpose of this study is to test the ability of virtual reality-based social support to increase patient adherence to radiation therapy by reducing patient distress.
- Trial name
- OU-SCC VR (NCT05263648)
- Testing
- Virtual Reality Session
- Sponsor
- University of Oklahoma
Bladder Cancer
Avelumab Plus Bacille Calmette-Guerin (BCG) in Patients With Non-muscle Invasive Bladder Cancer
The purpose of this study is to test the safety of avelumab and Bacille Calmette-Guerin (BCG) and see what effects (good and bad) that this combination treatment has on subjects with recurrent bladder cancer.
- Trial name
- OU-SCC-ABC (NCT03892642)
- Testing
- Avelumab, BCG
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oklahoma
Rheumatoid Arthritis, Inflammation
Ketogenic Diet in Rheumatoid Arthritis (RA)
This is a 6-week ketogenic diet (KD) intervention where participants with rheumatoid arthritis (RA) will follow a KD plan, supervised and monitored by a dietician.
- Conditions
- Rheumatoid Arthritis, Inflammation, Obesity, Ketogenic Dieting
- Trial name
- KETORA (NCT05799768)
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Oklahoma