Clinical trials: sponsored by University of Oklahoma
Multiple Chronic Conditions, Disability Physical
Behavioral Activation + Occupational Therapy
Approximately 45% of older adults in the U.S. have 2 or more chronic health conditions (e.g., arthritis, hypertension, diabetes) in addition to functional limitations that prevent performance of health self-management activities.
- Trial name
- BA+OT (NCT05600465)
- Testing
- Behavioral Activation + Occupational Therapy, Enhanced Usual Care
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma
Smoking Cessation
Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation
No published studies to date have evaluated the combined impact of varenicline and oral nicotine replacement therapy (NRT) on smoking cessation in a randomized trial.
- Trial name
- COMBOII (NCT07099638)
- Testing
- Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A)
- Where
- United States
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Breast Cancer Survivor
Self-Determination Theory-informed Occupational Therapy Program to Increase Physical Activity Among Survivors of Breast Cancer
We will evaluate a novel 8-week telehealth-delivered occupational therapy (OT) program among breast cancer survivors that seeks to promote engagement in aerobic physical activity (PA) and muscle strengthening exercise (MSE).
- Trial name
- SDOTS (NCT06671730)
- Testing
- 8-Week Telehealth-based Occupational Therapy Program
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Oklahoma
Prostate Cancer
MRI Fusion Biopsy vs. Micro-Ultrasound Guided Biopsy
The purpose of this study is to find out how best to detect clinically significant lesions of prostate cancer by using micro-ultrasound technology (ExactVu) and by multiparametric magnetic-resonance imaging (mpMRI).
- Trial name
- OU-SCC-PROBX (NCT05471128)
- Testing
- Standard of Care Biopsy
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Oklahoma
Solid Tumor, Adult
Advanced or Recurrent Solid Tumors Treated With SHetA2
The purpose of this research is to test the safety of the study drug (OK-1) and see what effects (good and bad) this drug has on patients with recurrent solid tumors.
- Trial name
- Okgyn1 (NCT04928508)
- Testing
- OK-1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Primary Graft Failure
REVEAL Biomarkers of Engraftment After Alternative Donor HSCT
The purpose of this study is to find new tests that could help determine if the newly infused bone marrow cells are growing well after bone marrow transplantation or if new bone marrow cells are needed.
- Trial name
- REVEAL (NCT03541889)
- Testing
- FLT imaging and TK1 blood measurements
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Head and Neck Squamous Cell Carcinoma
Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer
The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in…
- Trial name
- OUSCCMOTORX (NCT06477003)
- Testing
- Multispectral Optoacoustic Tomography, Temperature Measurement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Time Restricted Eating
Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT05488652
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Parkinson's Disease
NAD Supplementation in Parkinson's Disease
The goal of this clinical trial is to learn whether Nicotinamide Riboside, a form of Vitamin B3 also known as NR, can improve blood vessel health in the brain, memory, and physical function in eligible study participants.
- Trial name
- NCT07703137
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Systolic Heart Failure
Neuromodulation of Inflammation and Endothelial Function
Heart failure with reduced ejection fraction (HFrEF) is a major cause of mortality in United States. Aging is a major risk factor for adverse outcomes associated with HFrEF, with majority of the patient's over the age of 50…
- Trial name
- NCT05230732
- Testing
- neuromodulation device
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Oklahoma
Endometrial Cancer
Evaluating the Addition of OK-1 Weekly Paclitaxel in Patients With Endometrial Cancer
The purpose of this study is to evaluate whether treatment with the investigational drug OK-1 in combination with paclitaxel can reduce tumor burden in patients with advanced or recurrent endometrial cancer (A/R-EC).
- Trial name
- NCT07737795
- Testing
- OK-1 & Paclitaxel
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Oklahoma
Smoking Cessation, HIV
Smoking Cessation Program for Lao People With HIV
Tobacco use remains the leading modifiable risk factor for preventing cancer globally, particularly among people with HIV (PWH). In Laos, 61-80% of male PWH and 3-10% of female PWH smoke cigarettes.
- Trial name
- I-STOP (NCT07014605)
- Testing
- Smoking Cessation Self Help Guide, Smartphone-delivered Automated Messaging
- Where
- 2 sites in Laos
- Volunteers
- 1,200 people
- Sponsor
- University of Oklahoma
Impact of Supervision on Endoscopy Simulation Curriculum
Outcomes in Simulated Endoscopy Training
Eligible participants are those who are members of the general surgery residency pediatric gastroenterology fellowship, and adult gastroenterology fellowship.
- Trial name
- NCT03495141
- Testing
- Supervision/Coaching
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Elbow Fractures
Efficacy of the Buzzy System on Pain and Fear Reduction in Elbow Fracture Pin Removal
The goal of this study is to determine if the Buzzy System, a vibrating ice pack shaped like a bee reduces pain in removal of elbow fracture pin.
- Trial name
- NCT07520851
- Testing
- Flash Cards, Buzzy Ice pack
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Infertility
The Hysterosalpingogram (HSG) Experience And Tubal Spasm (HEAT) Study
The hysterosalpingogram (HSG) is the gold standard of assessing fallopian tube patency and involves the placement of a transcervical catheter to allow for instillation of radio-opaque dye into the uterine cavity and fallopian…
- Trial name
- HEAT (NCT07226310)
- Testing
- Warmed HSG
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
CRC Screening, CRC (Colorectal Cancer)
Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma
The Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program addresses major regional CRC screening disparities among AI in Oklahoma.
- Trial name
- YVONNE (NCT07254910)
- Testing
- Narrative Testimonial Video, v-TCHE Interaction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Pancreas Cancer, Hepatocellular Carcinoma
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry
The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screening tool for the early detection of cancer.
- Conditions
- Pancreas Cancer, Hepatocellular Carcinoma, Lung Cancer, Ovarian Cancer
- Trial name
- NCT07732686
- Testing
- Proton Transfer Reaction Mass Spectrometry Analysis
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Postural Tachycardia Syndrome
Autoimmune Basis for Postural Tachycardia Syndrome
The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT05043051
- Testing
- Vagal stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Rheumatoid Arthritis, Inflammation
Disulfiram in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation.
- Conditions
- Rheumatoid Arthritis, Inflammation, Obesity
- Trial name
- NCT07534332
- Testing
- Disulfiram (DSF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Cannabis Use, Risk Perception
Testing Warning Labels for Retail Cannabis Products Using a Discrete Choice Experiment
This discrete choice experiment (DCE) study aims to address gaps in cannabis packaging regulatory research by testing how variations in cannabis packaging and health warning design impact reactions to packaging and intentions…
- Conditions
- Cannabis Use, Risk Perception, Decision Making
- Trial name
- NCT07701304
- Testing
- Discrete choice experiment (DCE) survey-experiment
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Oklahoma