Clinical trials: sponsored by University of Oklahoma
Smoking Cessation
Mobile Contingency Management for Smoking Cessation
The purpose of the proposed project is to evaluate an automated mobile phone-based CM approach that will allow socioeconomically disadvantaged individuals to remotely benefit from financial incentives for smoking cessation.
- Trial name
- P3 (NCT04881630)
- Testing
- Automated Mobile Contingency Management (CM), Standard Care (SC)
- Where
- United States
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Chemotherapy-induced Peripheral Neuropathy
Wearable Focal Vibration for Chemotherapy-Induced Peripheral Neuropathy
This study will perform an early Phase I feasibility study with single-arm, double-baseline repeated measured design. The investigators will test the feasibility of using focal vibration to improve symptoms of persistent CIPN.
- Trial name
- NCT04959929
- Testing
- Focal vibration therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Oklahoma
Colorectal Carcinoma (CRC), Endometrial Carcinoma (EC)
Pilot Window of Opportunity Trial (POET)
The proposed clinical trial with TPST-1495 can help people with two types of cancer, Endometrial Cancer (EC) and Colorectal Carcinoma (CRC), who need surgery.
- Trial name
- NCT06129604
- Testing
- TPST-1495
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Oklahoma
Diet Habits, Cancer Prevention
Dietary Fiber and Time Restricted Eating
This study is seeking to examine combinations of two different dietary interventions on cancer risk.
- Trial name
- FIBER+TRE (NCT07219706)
- Testing
- Time Restricted Eating, Group education, Counseling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Alcohol Drinking, Heavy Drinking
Reset Challenge: Reducing High-risk Drinking for Cancer Prevention
This is a single-arm, non-randomized, prospective study to evaluate the feasibility and preliminary efficacy of a 30-day mobile Health (mHealth) Reset Challenge for reducing high-risk drinking.
- Conditions
- Alcohol Drinking, Heavy Drinking, Binge Drinking
- Trial name
- NCT07591428
- Testing
- 30-Day Alcohol Abstinence Challenge
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Missing Teeth
Osseodensification and Implant Survival and Success
Approximately 40 implants from patients seeking treatment at the University of Oklahoma, College of Dentistry will be recruited for this study.
- Trial name
- NCT04741594
- Testing
- Densah
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
AI-assisted Colonoscopy
AI_Colonoscopy_for_Fellows
The goal of this study is to look at how good artificial intelligence (AI) assisted colonoscopy is compared to conventional colonoscopy in detecting polyps when used by gastroenterology fellows.
- Trial name
- NCT07661914
- Testing
- AI assisted colonoscopy, Conventional Colonoscopy
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation
Small Financial Incentives to Promote Smoking Cessation
The primary objectives of this study are 1) to evaluate the longer-term impact of an adjunctive, low-cost financial incentives intervention (relative to standard care) on smoking abstinence rates among socioeconomically…
- Trial name
- PrevailII (NCT02737566)
- Testing
- Standard Care + Financial Incentives, Standard Care
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Oklahoma
Premature Birth
Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT
A Pragmatic Randomized Controlled Pilot Trial to Evaluate the Impact of Early Prophylactic Continuous Positive Airway Pressure with or without Supplemental Oxygen in Spontaneously Breathing Late Preterm Newborn Infants Born by…
- Trial name
- PLANT (NCT05204719)
- Testing
- Prophylactic Delivery Room Continuous Positive Airway Pressure
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Mild Cognitive Impairment (MCI), Amyloid Pathology
Using Light Therapy for Mild Cognitive Impairment
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and…
- Trial name
- LTMC (NCT07651787)
- Testing
- Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Low Grade Ovarian Serous Adenocarcinoma
Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)
This single arm phase II study proposes to evaluate the efficacy and safety of nab-sirolimus + endocrine therapy (Fulvestrant) in patients with recurrent low grade serous ovarian cancer (LGSOC).
- Trial name
- NCT06494150
- Testing
- nab-Sirolimus, Fulvestrant
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Oklahoma
Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II
Nebulized AER101 in Pre-op NSCLC
The primary objective of this pilot study is to determine if AER101 can decrease glycolysis in non-small cell lung cancer (NSCLC).
- Trial name
- AER101 (NCT07631299)
- Testing
- AER101
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Head and Neck Cancers
The Role of Dietary Fiber in Mitigating Sarcopenia Risk in Head and Neck Cancer
Emerging data suggest consumption of dietary fiber before and during cancer treatment may improve prognosis for patients with head and neck cancer, in part via increased production of short chain fatty acids, systemic…
- Trial name
- NCT07622914
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Oklahoma
Recurrent Endometrial Carcinoma, Recurrent Ovarian Carcinoma
Bevacizumab and/or Niraparib in Patients With Recurrent Endometrial and/or Ovarian Cancer With ARID1A Mutation
The purpose of this research study is to test the proportion of tumor response to the combination treatment with niraparib and bevacizumab and see what effects (good and bad) this combination treatment has on patients with…
- Conditions
- Recurrent Endometrial Carcinoma, Recurrent Ovarian Carcinoma, ARID1A Gene Mutation
- Trial name
- NCT05523440
- Testing
- Bevacizumab, Niraparib
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Oklahoma
HIV, Insulin Resistance
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma
The NOURISH-OK Study will identify how food insecurity contributes to insulin resistance, an important surrogate marker of many co-morbidities in HIV disease, using an integrated framework to identify key leverage points for…
- Conditions
- HIV, Insulin Resistance, Food Insecurity
- Trial name
- NOURISH-OK (NCT05208671)
- Testing
- NOURISH Food Box
- Where
- United States
- Volunteers
- 675 people
- Sponsor
- University of Oklahoma
Graft Vs Host Disease, Colitis
Optoacoustic Detection of Inflammation Using MSOT Device
The purpose of this study is to evaluate the safety and potential of a new experimental imaging instrument called multispectral optoacoustic tomography (MSOT) to detect inflammation in patients with chronic graft versus host…
- Conditions
- Graft Vs Host Disease, Colitis, Crohn Disease
- Trial name
- OU-SCC-O-FLAME (NCT05333978)
- Testing
- MSOT Device, Temperature Measurement
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Oklahoma
Exocrine Pancreatic Cancer
High Dose Omeprazole in Patients With Pancreatic Cancer
The purpose of this study is to test the safety of high dose omeprazole and see what effects that it has on patients with exocrine pancreatic cancer.
- Trial name
- OU202005AJ (NCT04930991)
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Oklahoma
Resectable Pancreatic Adenocarcinoma
Identify microRNAs in Cachexia in Pancreatic Carcinoma
The purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.
- Trial name
- SCC-miRPanCa (NCT05275075)
- Testing
- Pancreatic cancer microRNA and messenger RNA expression.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Prediabetes
Fiber mHealth Intervention for Prediabetes
This is a single-arm feasibility trial to examine an mHealth intervention that combines high fiber education, home-delivered high fiber foods, and use of continuous glucose monitors.
- Trial name
- GO-FAR (NCT07491653)
- Testing
- GO-FAR
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Claudication, Peripheral Artery Disease
The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the Non-Ischemic Exercise (NICE) program to improve exercise and vascular outcome measures in patients with peripheral…
- Trial name
- NICE (NCT05712395)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma