Clinical trials: sponsored by University of Oklahoma
Peripheral Artery Disease
NAD Supplementation and Vascular Health in PAD
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older…
- Trial name
- NCT06534944
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Cancer
Screening for Atrial Fibrillation in Patients With Cancer: A Pilot Randomized Controlled Clinical Trial
Patients with cancer have a higher incidence of AF but despite the higher incidence of AF in the cancer population, there are no randomized controlled trials (RCTs) for AF screening in this population.
- Trial name
- SARIC (NCT05784766)
- Testing
- 30-second ECG using the Kardia Mobile, routine care
- Where
- United States
- Volunteers
- 494 people
- Sponsor
- University of Oklahoma
Alcohol Dependence
Study of Acamprosate in Driving Under the Influence (DUI) Court Participants
Acamprosate will be given to approximately 30 DUI Court participants for 3 months and outcomes will be monitored. The hypothesis is that acamprosate will be safe and well-tolerated and that subjects' craving and other symptoms…
- Trial name
- NCT00425711
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Oklahoma
Recurrent Urinary Tract Infections
Recurrent Urinary Tract Infections and Heparin (RUTIH Trial)
Urinary Tract Infections (UTIs) are the second most common infection in the body. UTIs account for five percent of all visits to primary care physicians.
- Trial name
- NCT02246270
- Testing
- Intravesical Heparin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Stroke, Weakness of Extremities as Sequela of Stroke
Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke
The goal of this study is to determine the efficacy of electromechanical exoskeleton-assisted gait training on rehabilitation functional outcomes in patients with stroke undergoing therapy in an in-patient rehabilitation facility.
- Trial name
- NCT03980457
- Testing
- Indego Exoskeleton, Standard Rehabilitation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Cannabis Use
Cannabis Use on Sedation for Oral Surgery Procedures
The use of Cannabis is increasing in the population, and the effects that this might have on different medical procedures are poorly understood.
- Trial name
- NCT05873465
- Testing
- Sedation with Midazolam, Fentanyl, and Propofol, Extraction of teeth
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lung Cancer
Tribally Engaged Approaches to Lung Screening (TEALS)
Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and AI/AN have worse lung cancer incidence rates, survival, and death compared to the general population.
- Trial name
- TEALS (NCT04948060)
- Testing
- Enhanced lung cancer screening services
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Air Leakage
Digital Chest Tube Drainage System (Thopaz+) Versus Analog in Pediatric Patients
In 2007 the Thopaz digital drainage system was launched as one of the first chest tube drainage systems to utilize a digital rather than analog device.
- Trial name
- THOPAZ (NCT05511987)
- Testing
- Madela THOPAZ Digital Device, Atrium Analog Device
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Oklahoma
Diabetes Mellitus, Atrial Fibrillation
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
The study will investigate the effect of Dapagliflozin on atrial fibrillation (AF) burden. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm…
- Trial name
- NCT05174052
- Testing
- Dapagliflozin 10Mg Tab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Oklahoma
Peripheral Artery Disease, Endothelial Dysfunction
Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function in PAD
Peripheral arterial disease (PAD) constitutes a major public health burden. The incidence of PAD increases with age and is associated with other comorbid cardiovascular disorders.
- Conditions
- Peripheral Artery Disease, Endothelial Dysfunction, Autonomic Imbalance
- Trial name
- TVS-PAD (NCT03445754)
- Testing
- TVS
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Oklahoma
Heart Failure With Reduced Ejection Fraction
Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure
Heart failure (HF) is the leading cause of death in US. It is associated with abnormal vascular function termed endothelial dysfunction.
- Trial name
- TECO-HF (NCT03945058)
- Testing
- TVS
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Prostate Cancer
Using a mHealth App to Improve Quality-of-Life Outcomes in Black Prostate Cancer Survivors
The goal of this clinical trial is to ensure that the mobile health application for Black patients with prostate cancer (either actively undergoing treatment or survivors) is usable and acceptable to patients, get feedback about…
- Trial name
- NCT06651359
- Testing
- Surveys for Quality of Life, Surveys and mHealth App access
- Where
- 3 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Oklahoma
Hemorrhoids
Ketamine for Post-operative Analgesia in Hemorrhoidectomy
This is a prospective, randomized study of ketamine versus no ketamine in approximately 100 patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids.
- Trial name
- NCT04248205
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Septic Shock
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is the most expensive healthcare condition to treat in United States and has a mortality rate of nearly 30%.
- Trial name
- NERINASEPSIS (NCT03992378)
- Testing
- Low Level Transcutaneous Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Forehead; Wound
Topical CBD Scar Outcomes Study
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
- Trial name
- TOPSCAR (NCT05650697)
- Testing
- Group 1 cannabidiol (CBD) with silicone ointment, Group 2 silicone patch
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Oklahoma
Pneumothorax
Use of Endobronchial Ultrasound Scope (EBUS) Transducer to Identify Pneumothorax-A Feasibility Study
Endobronchial ultrasound (EBUS) is a technique that uses ultrasound along with bronchoscope to visualize airway wall and structures adjacent to it. Pneumothorax is a known complication from EBUS procedure.
- Trial name
- NCT02907866
- Testing
- Ultrasound with EBUS scope and with linear ultrasound probe
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Oklahoma
Aging
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
- Trial name
- NCT05483465
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pancreatic Cancer
Serum DCAMKL1 Pre and Post Treatment in Patients With Pancreatic Cancer
The investigators believe DCAMKL-1 is a stem cell tumor marker and is elevated in patients with pancreatic cancer. The investigators would like to analyze its expression pre and post treatment, to gauge the correlation between…
- Trial name
- NCT01580241
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Urothelial Carcinoma
Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma
The purpose of this research study is to test the safety of avelumab and AVB-S6-500 and see what effects (good and bad) this combination treatment has on patients with advanced urothelial carcinoma.
- Trial name
- COAXIN (NCT04004442)
- Testing
- Avelumab, AVB-S6-500
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Oklahoma
Obesity in Pregnancy, Labor Complication
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0
Obesity increases the risk of pregnancy complications, including puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- NCT06488781
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 787 people
- Sponsor
- University of Oklahoma