Clinical trials: sponsored by University of Oklahoma
Aging
L-Citrulline and Endothelial Function
The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease.
- Trial name
- NCT05722860
- Testing
- L-Citrulline, capsule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Prostate Cancer, Health Behavior
Prostate Cancer Genius App Education and Home-based PSA Screening for African American Men
Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early detection screening measure for prostate cancer.
- Trial name
- PCGA (NCT05331638)
- Testing
- Prostate Cancer Genius App, US Prevention Taskforce App
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Androgen Deprivation Therapy, Locally Advanced Prostate Cancer
Relugolix + Enzalutamide Study in High-Risk Prostate Cancer
The goal of this clinical trial is to test how effective and safe it is to use a combination of two medications, relugolix and enzalutamide, in patients with advanced prostate cancer.
- Trial name
- NCT06130995
- Testing
- Relugolix and Enzalutamide
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Oklahoma
Smoking Cessation Intervention, Pain
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
The goal of this pilot study is to assess whether 4-weeks of verified smoking abstinence following financial incentive treatment for smoking cessation improves physiological markers of chronic pain risk in adult Native American…
- Conditions
- Smoking Cessation Intervention, Pain, Smoking (Tobacco) Addiction
- Trial name
- OK-SNAPIV (NCT07080788)
- Testing
- Smoking Cessation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Clear Cell Renal Cell Carcinoma
Cemiplimab or Cemiplimab and Fianlimab After Stereotactic Body Radiotherapy in Clear Cell Renal Cell Carcinoma
The purpose of this research is to test the safety of PD-1 inhibitor cemiplimab with or without LAG-3 inhibitor fianlimab, and see what effects (good and bad) of cemiplimab either alone or combined with fianlimab has on patients…
- Trial name
- LAG-BOOST (NCT07223541)
- Testing
- Cemiplimab 350 MG Intravenous Solution, Fianlimab 1600 MG Intravenous Solution
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Oklahoma
Fallopian Tube Cancer, Fallopian Tube Infection
Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
This study will evaluate the impact of low dose aspirin on normal fallopian tube fimbriae in women who have surgery to have their fallopian tubes removed.
- Trial name
- NCT03771651
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oklahoma
Recurrent Cervix Cancer, Progressive Cervix Cancer
Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer
The purpose of this research study is to test the safety of Niraparib and dostarlimab as a combination treatment and see what effects (good and bad) this combination treatment has on patients with recurrent or progressive cervix…
- Trial name
- STAR (NCT04068753)
- Testing
- Niraparib, dostarlimab
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Oklahoma
Cognition, Neurovascular Coupling Mechanism and Cognitive Function
The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults
The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular…
- Conditions
- Cognition, Neurovascular Coupling Mechanism and Cognitive Function, Neurovascular Control, Brain Aging
- Trial name
- NCT07209683
- Testing
- transcranial photobiomodulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cancer Survivors
Improving Sleep, Fatigue, Activity & Quality of Life in Cancer Survivors Via a Transdiagnostic Intervention
Poor sleep affects over half of U.S. cancer survivors, contributing to daytime fatigue, reduced physical activity, and diminished quality of life.
- Trial name
- SLEEP-CARE (NCT07023783)
- Testing
- Transdiagnostic Sleep Health Intervention (TSHI)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Intermittent Fasting, Aging
The Effect of Intermittent Fasting on Brain Health
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT06019195
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Head and Neck Cancer, Gynecologic Cancer
Quality of Life Assessment of Radiotherapy in Recurrent Head and Neck Cancer
The purpose of this study is to examine the uses of a mobile health-based assessment and symptom monitoring platform.
- Conditions
- Head and Neck Cancer, Gynecologic Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT05850663
- Testing
- Ecologic Momentary Assessment (EMA)
- Sponsor
- University of Oklahoma
Urothelial Carcinoma
Circulating Tumor DNA Response In Urothelial Cancer
The purpose of this clinical trial is to evaluate the effectiveness of pembrolizumab monotherapy following 24 weeks of frontline pembrolizumab \& Enfortumab Vedotin (PEV) in patients with metastatic urothelial cancer (mUC).
- Trial name
- NCT07183319
- Testing
- Pembrolizumab & Enfortumab Vedotin (PEV), Pembrolizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Oklahoma
Hart Failure With Reduced Ejection Fraction
Magnesphere for Autonomic Alteration
To evaluate the physiologic effects of an electromagnetic resonator(EMF) on autonomic nervous system tone modulation through measurement of heart rate variability(HRV).
- Trial name
- NCT04207476
- Testing
- EMF
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Heart Failure With Normal Ejection Fraction
Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a leading cause of mortality in the elderly. Outcomes of patients with HFpEF are poor and so far, no treatment has been shown to decrease morbidity or mortality.
- Trial name
- NCT03327649
- Testing
- low level transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Cachexia-Anorexia Syndrome
Feasibility Study for Repurposing RET Inhibitors
The purpose of this study is to assess the effects of selpercatinib on cachexia and anorexia in patients diagnosed with NSCLC, colorectal cancer, or pancreatic cancer.
- Trial name
- FEATHER (NCT07146893)
- Testing
- Selpercatinib, Strength Assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Breast Cancer, Prostate Cancer
Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer
The purpose of this clinical trial is to evaluate radiation therapy (RT) completion rates among underrepresented cancer populations using qualitative measurements.
- Trial name
- NCT07014618
- Testing
- Pre & Post Surveys, Opt Out of Questionnaire
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- University of Oklahoma
Postoperative Pain, Acute, Skin Cancer
Meloxicam in Mohs Micrographic Surgery
The goal of this clinical trial is to explore alternative methods of postoperative pain control in Mohs micrographic surgery. The main aims are: To provide more information to the Mohs surgery community regarding postoperative…
- Trial name
- NCT07200544
- Testing
- Meloxicam 7.5 mg, Meloxicam 15 mg, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Cancer Pain, Opioid Use
Psychological Intervention Using Smartphone Technology to Alleviate Malignant Pain
The purpose of this study is to develop and pilot test a novel medical intervention (STAMP+CBT app) that will help patients track their pain, mood, opioid use and side effects while delivering tailored education and…
- Conditions
- Cancer Pain, Opioid Use, Cognitive Behavior Therapy
- Trial name
- STAMP+CBT (NCT05774197)
- Testing
- Cognitive Behavioral Therapy for pain
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Exogenous Ketosis
The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold
The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55.
- Trial name
- NCT07224282
- Testing
- Ketone supplementation, Carbohydrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Endometrioid Cancer, Mucinous Ovarian Cancer
A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib
The purpose of this research is to test the effectiveness and safety of the study drugs (VS-6766 and defactinib), and see what effects (good and bad) these drugs have on the patients with endometrioid cancer, mucinous ovarian…
- Conditions
- Endometrioid Cancer, Mucinous Ovarian Cancer, High Grade Serous Ovarian Cancer, Cervical Cancer
- Trial name
- DURAFAK (NCT05512208)
- Testing
- Avutometinib (VS-6766) + defactinib
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Oklahoma