Clinical trials: sponsored by University of Oklahoma
Metastatic Neoplasm to the Spine, Metastatic Neoplasm
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic…
- Trial name
- SPORTSMEN (NCT05617716)
- Testing
- Conventional external beam radiation therapy dose (EBRT), Spine radiosurgery/stereotactic body radiation therapy standard dose, Spine radiosurgery/stereotactic body radiation therapy high dose
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
Smoking Cessation
Testing a Novel Smartphone Application for Smoking Cessation With the Oklahoma Helpline
Over 470,000 tobacco users have been served by the Oklahoma Tobacco Helpline (OTH). The OTH reaches a substantial number of smokers each year, but follow-up rates are notoriously low and many smokers may prefer smartphone-based…
- Trial name
- OKquit (NCT05539209)
- Testing
- OKquit, Standard Helpline Care
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Child Abuse, Child Neglect
Promoting Resilience and Lowering Risk in Early Childhood
An intervention study to provide in-the-moment parenting tips with the goal of increasing healthy parent-child interactions leading to resiliency in high-risk children.
- Conditions
- Child Abuse, Child Neglect, Parenting, Child Development
- Trial name
- NCT05479734
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Oklahoma
CRC Screening, CRC (Colorectal Cancer)
Improving Rates of Diagnostic Colonoscopy in Native Americans
Colorectal cancer (CRC) is the second-leading cause of cancer death in both men and women in the United States. Compared to national averages, Native Americans (NA) endure a disproportionate burden of CRC incidence and…
- Trial name
- YVONNE-DX (NCT07115875)
- Testing
- Digital Outreach, In Person consultation
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Oklahoma
Prostate Cancer, Health Behavior
Connect2Care: Prostate Cancer Education and Screenings for African American Men
Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early detection screening tool for prostate cancer…
- Trial name
- NCT07055165
- Testing
- Prostate Cancer Genius App, US Prevention Taskforce App
- Where
- United States
- Volunteers
- 466 people
- Sponsor
- University of Oklahoma
Tobacco Use
Attitudes and Smoking Perceptions in the Real Environment
This study will measure appeal and reinforcement for different flavored little cigars/cigarillos (LCCs) in young adults in the laboratory and at-home, via ecological momentary assessment (daily smart-phone surveys)
- Trial name
- ASPIRE (NCT06617520)
- Testing
- Cigarillo flavor type
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pulmonary Hypertension
Neuromodulation in Patients With Pulmonary Arterial Hypertension
Patients with Group 1 pulmonary hypertension will be enrolled in this study. Investigators will test the hypothesis of low-level tragal stimulation in patients with pulmonary hypertension.
- Trial name
- NIP (NCT06802380)
- Testing
- Low-level tragus stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Tobacco Use
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
This pilot randomized trial will assess the impact of 12 weeks of semaglutide administration (vs placebo) on changes in: (i) tobacco use and related factors (nicotine craving, withdrawal, motivation to quit, etc.) and (ii)…
- Trial name
- ONSET (NCT06986993)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Cigarette Smoking, Smoking Behaviors
Cigarette Smoking Among Young Adults
This study will examine perceptions and smoking behavior of menthol and non-menthol very low nicotine cigarettes in young adult smokers.
- Trial name
- ENHANCE (NCT04340947)
- Testing
- Very low nicotine cigarette: menthol, Very low nicotine cigarette: non-mentol
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation
Smartphone Based Smoking Cessation Intervention
Smoking is becoming increasingly concentrated among individuals with the lowest levels of income, education, and occupational status.
- Trial name
- Smart-TR01 (NCT03740490)
- Testing
- Smart-T + NRT, QuitGuide + NRT
- Where
- United States
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarillo Flavor
Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II
This multi-method project will recruit young adults who currently use cigarillos and examine the effects of different flavored cigarillo types (concept, characterizing, tobacco) on three measures of tobacco product appeal…
- Trial name
- ASPIRE-II (NCT06668350)
- Testing
- Smoking outcomes
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking
Mobile Health Technology for Personalized Tobacco Cessation Support in Laos
In Lao People's Democratic Republic (Lao PDR), 51% of adult men and 7% of adult women smoke tobacco. The development and evaluation of sustainable tobacco cessation interventions suitable for widespread adoption in nations such…
- Trial name
- SupportLaos (NCT05233228)
- Testing
- Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation
- Where
- 2 sites in Laos
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Alcohol Use Disorder, Substance Use Disorders
Evaluating a One-Year Version of the Parent-Child Assistance Program
The proposed project seeks to achieve three objectives that will, collectively, evaluate the effectiveness of a one-year version of the Parent-Child Assistance Program (PCAP-1) -a model for a home visitation and case management…
- Conditions
- Alcohol Use Disorder, Substance Use Disorders, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use Disorders
- Trial name
- PCAP-1 (NCT06163651)
- Testing
- Parent-Child Assistance Program - One-Year Version
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Cancer Survivorship
Cooperative Extension and Cancer Survivorship
The goal of this clinical trial is to learn if a cancer survivor program, delivered via Cooperative Extension, is feasible and if it can improve health outcomes in cancer survivors who are post-active treatment.
- Trial name
- SUCCESS (NCT06869512)
- Testing
- SUCCESS
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Obesity, Vascular Dementia
Urolithin A Supplementation in Middle-aged Adults With Obesity
The goal of this clinical trial is to learn about the effect of urolithin A, a dietary supplement, on blood flow in middle-aged adults with obesity.
- Conditions
- Obesity, Vascular Dementia, Cognitive Impairment
- Trial name
- NCT05921266
- Testing
- Urolithin A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Recurrent Glioblastoma, Recurrent Astrocytoma
PARP Inhibition for Gliomas (PI-4G or π4g)
The purpose of this study is to determine what effects (good and bad) niraparib has on patients with recurrent brain cancer.
- Conditions
- Recurrent Glioblastoma, Recurrent Astrocytoma, Recurrent Oligodendroglioma, Recurrent Glioma
- Trial name
- OU-SCC-PI-4G (NCT05297864)
- Testing
- Niraparib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Oklahoma
Obesity, Endometrial Cancer
Bariatric Education for Women With Obesity and Endometrial Cancer
The purpose of this study is to examine whether a standardized video education tool will improve knowledge regarding obesity and bariatric surgery and increase bariatric surgery referrals for obese women with endometrial cancer.
- Conditions
- Obesity, Endometrial Cancer, Bariatric Surgery Candidate
- Trial name
- SCC-BAREDU (NCT05396794)
- Testing
- Standard weight loss education, Standard weight loss education + Educational Video
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Oklahoma
Smoking Cessation
Empowering LGBTQ+ Tobacco Cessation Pilot
Sexual and/or gender minority (SGM) people have disproportionately high rates of tobacco use - the number one cause of preventable death.
- Trial name
- NCT05365633
- Testing
- Empowerment activity-enhanced tobacco cessation assistance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Discrimination, Racial, Stress Physiology
Oklahoma Study of Native American Pain Risk III: Stress and Resilience
The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are: 1.
- Conditions
- Discrimination, Racial, Stress Physiology, Pain
- Trial name
- OK-SNAPIII (NCT05723081)
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma