Clinical trials: open to volunteers, sponsored by University of Pennsylvania
Traumatic Brain Injury
Sildenafil for Microvasculopathy in Chronic TBI
Traumatic Cerebral Vascular Injury (TCVI) is a common consequence of traumatic brain injury (TBI), including mild TBI (mTBI). TCVI is associated with poor recovery after TBI in animal models.
- Trial name
- CVR-TBI (NCT05782244)
- Testing
- Sildenafil Citrate low dose, Sildenafil medium dose, Sildenafil high dose
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Pennsylvania
Sleep Initiation and Maintenance Disorders, Pregnancy Related
Behavioral Relaxation Approaches for Insomnia in Pregnant Patients
This study will evaluate the effect of a simplified behavioral relaxation intervention to improve insomnia in pregnant women
- Trial name
- NCT05530863
- Testing
- Assisted Therapy, Sleep Hygiene
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Integrating Brain, Neurocognitive, and Computational Tools in OUD
The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on…
- Trial name
- NCT06136247
- Testing
- Neurocognitive battery, fNIRS
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Pennsylvania
Depression
Antidepressant Adherence for Depressed Adults in Primary Care
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
- Trial name
- NCT06496646
- Testing
- Arm 1 intervention, Arm 2 Intervention
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- University of Pennsylvania
Carotid Plaque
CT Evaluation of Carotid Plaque Components
The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the…
- Trial name
- NCT05764772
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
End Stage Kidney Disease
Symptom Monitoring in Hemodialysis
The SMaRRT-HD trial is a cluster randomized trial of symptom monitoring with supported clinician follow-up using the SMaRRT-HD electronic patient reported outcome measure (ePROM) system versus Usual Care.
- Trial name
- SMaRRT-HD (NCT05738330)
- Testing
- Symptom Monitoring on Renal Replacement Therapy - Hemodialysis (SMaRRT-HD), Usual Care
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Pennsylvania
Ventricular Tachycardia
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.
- Trial name
- NCT05377216
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Tauopathies
Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 11C HY-2-15. The goal of this radiotracer is to quantify alpha-synuclein that is abnormally deposited in the brain of people with…
- Trial name
- NCT06032026
- Testing
- 11C-HY-2-15 PET, brain MRI, Amyloid PET scan
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea of Adult
Imaging Predictors of Cryolysis Efficacy for Treatment of Obstructive Sleep Apnea
The goal of this observational study is to further evaluate the efficacy and mechanism of action of the Cryosa Procedure, a novel procedure intended to treat obstructive sleep apnea (OSA).
- Trial name
- ICE-OSA (NCT06434558)
- Testing
- Cryosa Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Posttraumatic Stress Disorder
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD).
- Trial name
- NCT06234969
- Testing
- Continuous Theta Burst Stimulation to the Intraparietal Sulcus
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Stress Disorders, Post-Traumatic, Premature Birth
Postpartum Care in the NICU (PeliCaN) Transitions
This is a randomized controlled trial of a dyad-centered, doula support and healthcare coordination model of care in a large urban neonatal intensive care unit (NICU), which serves a high-risk, low-income, majority Black…
- Conditions
- Stress Disorders, Post-Traumatic, Premature Birth, Postpartum Depression, Postpartum Anxiety
- Trial name
- PeliCaN (NCT06521398)
- Testing
- Doula Support
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Plantar Fascitis
Plantar Fasciitis Randomized Clinical Control Trial
The primary aim of this clinical experiment is to compare, in terms of pain relief measured using the 10-cm visual analog scale (VAS) pain score (5-7), the clinical results of ultrasound-guided injection (USGI) versus anatomic…
- Trial name
- PF-RCT (NCT03231150)
- Testing
- Local Steroid Injection into the plantar heel, Ultrasound Guided Injection, Anatomical Guided injection
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hypocholesterolemia
Physiological Effects of ANGPTL3 Variants in Humans
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
- Trial name
- NCT04234724
- Testing
- Kinetics test, oral fat tolerance test, and an oral glucose tolerance test.
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Apical Periodontitis
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled…
- Trial name
- NCT06545084
- Testing
- Leukocyte and Platelet Rich Fibrin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation.
- Trial name
- NCT04275453
- Testing
- FDG, Ketone Drink, Ketogenetic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania