Clinical trials: open to volunteers, sponsored by University of Pennsylvania
Poverty, Incarceration
Cash Transfers for Reentry
Investigators will execute a mixed methods randomized controlled trial to determine the impacts of cash transfers of $1,000 per month for one month followed by $750 for eleven months.
- Trial name
- NCT07265375
- Testing
- Cash transfer
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Pennsylvania
HIV
City-Wide Implementation and Evaluation of the B-OK Bottles for HIV Treatment Adherence Support in the Philadelphia Ryan White Medical Case Management Network
The researchers will conduct a hybrid implementation-effectiveness study of a city-wide B-OK rollout led by PDPH with research and evaluation support from the University of Pennsylvania.
- Trial name
- B-OK PDPH (NCT07807137)
- Testing
- B-OK Bead Bottles
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tuberculosis, Pulmonary
Fibroblast Activating Protein (FAP) PET/CT in Adults With Tuberculosis
This is an early phase study in patients with Tuberculosis (TB) to evaluate Fibroblast Activating Protein (FAP) activation as a marker of fibrosis.
- Trial name
- NCT07830771
- Testing
- [18F]-FAPI-74
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
HIV/STI Incidence, Communication About Health Information
The Gender Inclusive Sexuality Talks Program
The study is centered on helping parents answer and meet the sexuality-specific questions and needs of transgender, gender diverse, lesbian or bisexual female youth.
- Trial name
- GIST (NCT07825571)
- Testing
- The Gender Inclusive Sexuality Talks Program, GIST Control
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Episodic Memory
Posterior Cingulate Cortex and Executive Control of Episodic Memory
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior.
- Trial name
- NCT06540976
- Testing
- Cognitive testing
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pennsylvania
Relapsed or Refractory Follicular Lymphoma
huCART19-IL18-eDHFR Cells in Relapsed/Refractory Follicular Lymphoma
This is a phase 1, open-label study to evaluate the feasibility, safety and preliminary efficacy of huCART19-IL18-eDHFR cells administered in patients with relapsed or refractory follicular lymphoma.
- Trial name
- NCT07343934
- Testing
- huCART19-IL18-eDHFR cells, [18F]Fluoropropyl-Trimethoprim
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Insomnia, Insomnia Disorder
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for…
- Conditions
- Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
- Trial name
- NCT07542756
- Testing
- Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pennsylvania
Hemothorax; Traumatic
Traumatic Hemothorax Drainage and Daily Lavage
This HTX treatment study evaluates the effects of chest tube size and the benefits of daily irrigations on acute HTX. 20 acutely injured but stable trauma patients requiring a chest tube for HTX will be enrolled.
- Trial name
- HTXDLYLAVGE (NCT06937450)
- Testing
- CLR Irrigator, Serial Lavage and Drainage, 28 Fr Open Chest Tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Healthy Adults
Validation of NAD+ Measurements for Human Clinical Studies
The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance…
- Trial name
- NCT07416786
- Testing
- Oral NR Supplementation
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pre-Eclampsia, Pregnancy Loss
APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia
The goal of this clinical trial is to investigate the effects of early initiation of double low-dose aspirin in pregnant women. The main questions it aims to answer are: Does this dose and timing of aspirin reduce the risk of…
- Trial name
- APPLE (NCT06408181)
- Testing
- Aspirin 162 mg, Aspirin 81mg
- Where
- United States
- Volunteers
- 1,150 people
- Sponsor
- University of Pennsylvania
Dental Caries
Building Adaptive School-based Interventions for Caries
Dental caries (tooth decay) is the world's most prevalent noncommunicable disease. Current preventive and therapeutic treatments are available that can be provided in a school-based health service environment.
- Trial name
- BASICS (NCT07265830)
- Testing
- Silver Diamine Fluoride (38%), Glass Ionomer Sealant, Fluoride Varnishes
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Care Patients, Primary Care Provider
Evaluating the Preferences and Tradeoffs of AI-based Electronic Consultations for Older Adults in Primary Care
Electronic consultations, or e-consults, let a primary care doctor request medical advice from a specialist without requiring the patient to attend a separate visit.
- Trial name
- NCT07766694
- Testing
- Discrete Choice Experiment Survey
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Pennsylvania
Depression, Major Depressive Disorder (MDD)
Individualized fMRI-guided TMS for Depression
The goal of this clinical trial is to learn how transcranial magnetic stimulation (TMS) affects brain circuits involving the subgenual anterior cingulate cortex (sgACC) in adults with depression.
- Conditions
- Depression, Major Depressive Disorder (MDD), Depression - Major Depressive Disorder, Persistent Depressive Disorder
- Trial name
- R33 MDD (NCT07804459)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Bacterial Infections
[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects
The purpose of this study is to study a radioactive tracer, a type of imaging drug that is injected into the body to see how it is taken up in sites of active infection using an imaging procedure called Positron Emission…
- Trial name
- NCT04263792
- Testing
- [18F]fluoropropyl-trimethoprim
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Poverty, Education Advancement
Negative Income Tax Trial
In partnership with a local community college in in Omaha, Nebraska, the Center for Guaranteed Income Research (CGIR) at the University of Pennsylvania will conduct a randomized controlled trial to determine the impacts of a…
- Trial name
- NITT (NCT07463131)
- Testing
- Negative Income Tax, Control
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- University of Pennsylvania
Alzheimer's Disease
Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive…
- Trial name
- MCP (NCT05658913)
- Testing
- AV-1451
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Depression - Major Depressive Disorder, Catatonia
Optimizing Stimulation Parameters for Electroconvulsive Therapy
The goal of this clinical trial is to improve how electroconvulsive therapy (ECT) stimulation settings are chosen. Researchers will use real-time brain monitoring to measure both seizures and a recently identified brain event…
- Trial name
- PRESTO (NCT07561307)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Speech Perception
Dynamic Neural Mechanisms of Audiovisual Speech Perception
Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the…
- Trial name
- NCT04290130
- Testing
- Measurement of brain activity using electrodes.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Rumination, Major Depressive Disorder
Decoding and Modulating Affective Brain States
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS).
- Conditions
- Rumination, Major Depressive Disorder, Anxiety
- Trial name
- NCT05437705
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Relapsing Polychondritis
Pragmatic, Open-Label Study to Pilot Evaluation for Clinical Trials in Relapsing Polychondritis
Open label pragmatic two-stage non-randomized trial comparing the effectiveness of five different standard of care treatment options for patients with relapsing polychondritis (RP).
- Trial name
- PROSECT RP (NCT06941376)
- Testing
- Methotrexate (MTX), Azathioprine (AZA), Adalimumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania