Clinical trials: open to volunteers, sponsored by University of Pennsylvania
Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis)
Biofluid Research on Age-Related or Inherited Neurodegeneration
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with…
- Conditions
- Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial Frontotemporal Lobar Degeneration (fFTLD)
- Trial name
- BRAIN (NCT07798700)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
PTSD, Post Traumatic Stress Disorder (PTSD)
Individualized (fMRI-guided) TMS Intervention for Post-Traumatic Stress Disorder (PTSD)
The goal of this clinical trial is to learn how transcranial magnetic stimulation (TMS) affects brain circuits involving the amygdala in adults with posttraumatic stress disorder (PTSD).
- Trial name
- NCT07785908
- Testing
- Active Transcranial Magnetic Stimulation (TMS)
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome
Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare immune system disorder that causes asthma, an excessive number of eosinophils (a type of white blood cell) in the blood, and the inflammation of blood vessels, or…
- Trial name
- NCT00315380
- Where
- 15 sites in United States, Canada and 3 more
- Volunteers
- 700 people
- Sponsor
- University of Pennsylvania
Hyperparathyroidism, Primary
Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism
The goal of this study is to address surgical health equity in historically marginalized participants with primary hyperparathyroidism (PHPT).
- Trial name
- NCT06562881
- Testing
- Scheduling Navigation, Without Scheduling Navigation
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Pennsylvania
HIV, HIV Treatment
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Consistent use of antiretroviral therapy (ART) is essential for achieving suppression among people with HIV (PWH). Yet despite improvements in access to ART and improving viral suppression rates, an estimated one-third of PWH…
- Trial name
- NCT07703891
- Testing
- B-OK Bead Bottles Intervention (delivered in person), B-OK Bottles Intervention (delivered by video), Control
- Where
- South Africa
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulmonary Arterial Hypertension
Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass-Substudy
After completion of the Baseline study visit for the main study (MUSCLE UP-PH), participants at the University of Pennsylvania location will be invited to participate in an optional substudy.
- Trial name
- MUSCLE-UPSUB (NCT07781709)
- Testing
- Measurement of oxyhemoglobin and deoxyhemoglobin concentration pre and post- exercise at baseline and Week 12. Measurement of time to recovery of oxyhemglobin post-exercise at baseline and at Week 12., Blood draw
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Alzheimer Disease and Related Dementias (ADRD)
Veech Ketone Ester to Support Brain Energy in Mild Cognitive Impairment and Early Alzheimer's Disease
It is projected that by 2030, one in every five Americans will be of retirement age, and this demographic shift is expected to result in more people suffering from dementia.
- Trial name
- NCT06767124
- Testing
- Ketogenic Supplement
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of Pennsylvania
Suicidal Ideation, Suicidal
Reward Sensitivity Digital Intervention for Suicide Risk
The goal of this clinical trial is to develop and test an app designed to reduce suicide risk and improve emotional well-being in adolescents.
- Conditions
- Suicidal Ideation, Suicidal, Suicidal Thoughts, Digital Health Intervention
- Trial name
- DIGIReward (NCT07661901)
- Testing
- Suicide prevention treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Stroke, Aphasia, Acquired
tACS to Enhance Language Abilities
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia.
- Conditions
- Stroke, Aphasia, Acquired, Aphasia
- Trial name
- NCT06092814
- Testing
- Active transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa
A Randomized Multicenter Study for Isolated Skin Vasculitis
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
- Conditions
- Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa, IgA Vasculitis, Henoch-Schönlein Purpura
- Trial name
- ARAMIS (NCT02939573)
- Testing
- Colchicine, Dapsone, Azathioprine
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 90 people
- Sponsor
- University of Pennsylvania
Giant Cell Arteritis
Abatacept for the Treatment of Giant Cell Arteritis
This randomized, double-blind, placebo-controlled trial will seek to determine the efficacy of abatacept in GCA. To examine this objective, 62 eligible patients who have newly diagnosed or relapsing GCA within 8 weeks prior to…
- Trial name
- NCT04474847
- Testing
- Abatacept
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- University of Pennsylvania
Hypothyroidism Primary
T4/T3 Therapy in Hypothyroidism
This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with…
- Trial name
- NCT07424183
- Testing
- Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Chin Regression, Chin Asymmetry
Evaluation of Filler Injection for Chin Profile Enhancement
The goal of this prospective study is to analyze volumetric changes in the lower face after hyaluronic acid filler injections over 90 days.
- Conditions
- Chin Regression, Chin Asymmetry, Jawline Contour Deficit
- Trial name
- NCT07777926
- Testing
- HA Filler
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cystic Fibrosis, Infections
Remote Sputum Collection in Cystic Fibrosis
Elexacaftor/Tezacaftor/Ivacaftor or Trikafta improves lung health in people with cystic fibrosis (CF), including decreased cough and mucous production.
- Trial name
- RESCUe (NCT06950892)
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Acute Ischemic Stroke From Large Vessel Occlusion
Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy
This is a prospective, single-arm, open-label study to evaluate the efficacy of intra-arterial tenecteplase in improving microvascular reperfusion following successful large vessel recanalization.
- Trial name
- INTIMA-MT (NCT06904911)
- Testing
- intra-arterial tenecteplase administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Heart Failure
Pilot Study Exploring the Feasibility, Acceptability, and Impact of Medically Tailored Meals on Post-Discharge Recovery in Patients With Heart Failure
The goal of this interventional pilot study is to evaluate the feasibility, acceptability, and impact of medically tailored meals (MTM) on post-discharge recovery in patients with heart failure for Penn Medicine patients in…
- Trial name
- HF-MTM (NCT07251894)
- Testing
- Medically Tailored Meals
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Pennsylvania
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
HIV
Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships
The goal of this study is to learn if STEP-UP (Streamlining Telehealth for Expanded PrEP Utilization through community Partnerships) works to expand access to PrEP for people who could benefit from HIV prevention tools.
- Trial name
- STEP-UP (NCT07246057)
- Testing
- STEP-UP, Philadelphia TelePrEP Program Direct-to-Consumer Model
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Care Transitions
Improving Care Transitions for Medicaid Insured Individuals With Co-occurring Serious Mental Illness
This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization.
- Trial name
- THRIVE-SMI (NCT06203509)
- Testing
- Thrive Intervention
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Misuse Treatment, Alcohol Misuse
Designing and Evaluating Multi-level Implementation Strategies to Address Alcohol Use Within Oncology Care
To assess the potential effects of our multi-level implementation strategies for increasing SBIRT for alcohol use among cancer patients and to refine our methods, the investigators are conducting a pilot-trial with 4 clinics and…
- Trial name
- NCT07752576
- Testing
- Multi-level Implementation Strategy
- Volunteers
- 265 people
- Sponsor
- University of Pennsylvania