Clinical trials: open to volunteers, sponsored by University of Pennsylvania
Hypothyroidism Primary
T4/T3 Therapy in Hypothyroidism
This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with…
- Trial name
- NCT07424183
- Testing
- Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Giant Cell Arteritis
Abatacept for the Treatment of Giant Cell Arteritis
This randomized, double-blind, placebo-controlled trial will seek to determine the efficacy of abatacept in GCA. To examine this objective, 62 eligible patients who have newly diagnosed or relapsing GCA within 8 weeks prior to…
- Trial name
- NCT04474847
- Testing
- Abatacept
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- University of Pennsylvania
Chin Regression, Chin Asymmetry
Evaluation of Filler Injection for Chin Profile Enhancement
The goal of this prospective study is to analyze volumetric changes in the lower face after hyaluronic acid filler injections over 90 days.
- Conditions
- Chin Regression, Chin Asymmetry, Jawline Contour Deficit
- Trial name
- NCT07777926
- Testing
- HA Filler
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cystic Fibrosis, Infections
Remote Sputum Collection in Cystic Fibrosis
Elexacaftor/Tezacaftor/Ivacaftor or Trikafta improves lung health in people with cystic fibrosis (CF), including decreased cough and mucous production.
- Trial name
- RESCUe (NCT06950892)
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Acute Ischemic Stroke From Large Vessel Occlusion
Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy
This is a prospective, single-arm, open-label study to evaluate the efficacy of intra-arterial tenecteplase in improving microvascular reperfusion following successful large vessel recanalization.
- Trial name
- INTIMA-MT (NCT06904911)
- Testing
- intra-arterial tenecteplase administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Heart Failure
Pilot Study Exploring the Feasibility, Acceptability, and Impact of Medically Tailored Meals on Post-Discharge Recovery in Patients With Heart Failure
The goal of this interventional pilot study is to evaluate the feasibility, acceptability, and impact of medically tailored meals (MTM) on post-discharge recovery in patients with heart failure for Penn Medicine patients in…
- Trial name
- HF-MTM (NCT07251894)
- Testing
- Medically Tailored Meals
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Pennsylvania
HIV
Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships
The goal of this study is to learn if STEP-UP (Streamlining Telehealth for Expanded PrEP Utilization through community Partnerships) works to expand access to PrEP for people who could benefit from HIV prevention tools.
- Trial name
- STEP-UP (NCT07246057)
- Testing
- STEP-UP, Philadelphia TelePrEP Program Direct-to-Consumer Model
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Care Transitions
Improving Care Transitions for Medicaid Insured Individuals With Co-occurring Serious Mental Illness
This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization.
- Trial name
- THRIVE-SMI (NCT06203509)
- Testing
- Thrive Intervention
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Misuse Treatment, Alcohol Misuse
Designing and Evaluating Multi-level Implementation Strategies to Address Alcohol Use Within Oncology Care
To assess the potential effects of our multi-level implementation strategies for increasing SBIRT for alcohol use among cancer patients and to refine our methods, the investigators are conducting a pilot-trial with 4 clinics and…
- Trial name
- NCT07752576
- Testing
- Multi-level Implementation Strategy
- Volunteers
- 265 people
- Sponsor
- University of Pennsylvania
Preterm Birth, Activity Restriction
DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention
DE-RESTRICT is a pilot study testing whether a strategy to reduce the use of activity restriction and bedrest in pregnancy is acceptable, appropriate, and feasible for prenatal care providers, and whether it changes how often…
- Conditions
- Preterm Birth, Activity Restriction, Bed Rest, Low-Value Care
- Trial name
- NCT07698483
- Testing
- Multicomponent deimplementation strategy
- Where
- 2 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiac Arrest, Cardiac Arrest Circulatory
Resuscitative TEE Collaborative Registry
The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and…
- Conditions
- Cardiac Arrest, Cardiac Arrest Circulatory, Cardiac Arrest, Out-Of-Hospital, Shock
- Trial name
- rTEECoRe (NCT04972526)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
B-Cell Non-Hodgkin Lymphoma (NHL), Richter's Transformation
CD45BE-HSPC + CART-45 Cells
This is a phase 1, open-label, dose-finding study to assess the safety, feasibility, pharmacokinetics and preliminary efficacy of autologous base edited anti-CD45 CAR T cells (referred to as "CART-45 cells") following an…
- Conditions
- B-Cell Non-Hodgkin Lymphoma (NHL), Richter's Transformation, T-Cell Non-Hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- NCT07451054
- Testing
- CART-45 cells, CD45BE-HSPC
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Pennsylvania
Lymphatic Obstruction
18F-FTHA IMAGING OF THE INTESTINAL AND CENTRAL LYMPHATIC SYSTEM
The project will be performed over a period of approximately two years. In the first year the [18F]FTHA tracer will be developed, optimized, and tested on normal volunteers.
- Trial name
- FTHA (NCT07645573)
- Testing
- [18F]FTHA PET/CT scan
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Essential Tremor
Image-Guided DBS Programming
The objective of this study is to compare the effects of image-guided programming algorithm using various image segmentations vs standard clinical programming on reduction of tremor and patient satisfaction.
- Trial name
- NCT07433699
- Testing
- programming a, programming b
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Brain Plasticity
Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance
Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS.
- Trial name
- NCT07565207
- Testing
- TBS
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anxiety
Arousal-related Memory Following Theta Burst Stimulation.
Aim 1: Active cTBS to IPS will disrupt arousal-dependent temporal memory, reflected in reduced relative order discrimination accuracy and expanded temporal distance estimates, relative to sham.
- Trial name
- NCT07565194
- Testing
- Active TMS
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Ketogenic Diet, Alcohol Drinking
Effects of Ketogenic Diet on Alcohol Intoxication
The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Participants will be asked to undergo ~4 weeks of ketogenic diet intervention.
- Conditions
- Ketogenic Diet, Alcohol Drinking, Alcohol Use Disorder, Magnetic Resonance Imaging
- Trial name
- NCT07602270
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Behavior, Health
Colorectal Cancer Screening Preventive Reminder Ordering AssistanCe Via Texting for Improved Visit Encounters
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. A substantial portion of the United States population remains overdue for screening, despite availability and insurance coverage of…
- Trial name
- CRC PROACTIVE (NCT07636174)
- Testing
- Post-visit patient messaging
- Where
- United States
- Volunteers
- 3,888 people
- Sponsor
- University of Pennsylvania
Behavior, Health
Preventive Reminder Ordering AssistanCe Via Texting for Improved Visit Encounters
A substantial portion of the United States population remains overdue for key screenings, despite availability and insurance coverage of preventive health services.
- Trial name
- PROACTIVE (NCT07636187)
- Testing
- Pre-visit and post-visit patient messaging, Default pended order, EHR communication
- Where
- United States
- Volunteers
- 16,416 people
- Sponsor
- University of Pennsylvania