Clinical trials: sponsored by University of Pittsburgh
Diabetes Mellitus, High Blood Pressure
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
The objective of this study is to compare the effectiveness of a novel program-Family Support for Health Action (FAM-ACT) - to individual patient-focused diabetes self-management education and support (I-DSMES).
- Conditions
- Diabetes Mellitus, High Blood Pressure, High Blood Sugar, Hypertension
- Trial name
- NCT03812614
- Testing
- FAM ACT, I-DSMES
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Pittsburgh
Breast Feeding
A Mobile, Semi-automated Text Message-based Intervention to Prevent Perceived Low or Insufficient Milk Supply
The purpose of this pilot randomized trial is to determine the effectiveness, feasibility, and acceptability of a mobile, semi-automated text message-based intervention (MILK) to prevent perceived low or insufficient milk supply…
- Trial name
- MILK (NCT02724969)
- Testing
- MILK or Text4Baby text message intervention
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pregnancy Complications, Sedentary Behavior
Sedentary Behavior Reduction in Pregnancy Intervention Study
This pilot and feasibility study will enroll newly pregnant women at risk for high sedentary behavior (SED) and elevated APO risk (n=53) and will randomize them to either a SED reduction intervention or control.
- Trial name
- SPRING (NCT05093842)
- Testing
- Sedentary Behavior Reduction, Information on Physical Activity Recommendations during Pregnancy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Pittsburgh
Hypertension, Prehypertension
Effect of Reducing Sedentary Behavior on Blood Pressure
This is a 2-arm, 3-month randomized trial comparing a novel sedentary behavior intervention vs. control in working adults (n=271).
- Trial name
- RESET-BP (NCT03307343)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- University of Pittsburgh
Nocturia, Hypertension
Sleep, Hypertension, and Nocturia: a Multicomponent Approach for Comorbid Illnesses
In this study the investigators target three common and comorbid illnesses among older adults namely nocturia or waking at night to void, poor sleep and hypertension.
- Conditions
- Nocturia, Hypertension, Sleep Disturbance
- Trial name
- SHyN (NCT05419830)
- Testing
- BBTI, PM antihypertensive dosing or Chronotherapy, AM antihypertensive dosing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Hearing Loss, Age-Related
Hearing for Communication and Resident Engagement
Amplification is a well-established, evidence-based front-line treatment for those with impaired communication secondary to Age Related Hearing Loss (ARHL).
- Trial name
- HearCARE (NCT04575051)
- Testing
- Consult Model, Engage Model
- Where
- United States
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cirrhosis, Liver
Improving Pain Management and Opioid Safety for Patients With Cirrhosis
This project aims to test a behavioral intervention in patients with liver cirrhosis and chronic pain and teach self pain-management skills.
- Trial name
- NCT05128578
- Testing
- Liver Education About Pain (LEAP), Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Laceration, Anxiety
Intranasal Dexmedetomidine vs Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair
The objective of this research study is to show superiority of intranasal dexmedetomidine to intranasal midazolam as anxiolysis prior to pediatric laceration repairs.
- Trial name
- NCT02168439
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Exercise, Lung Transplantation
Lung Transplant G0 (LTGO): Improving Self-Management of Exercise After Lung Transplantation
Estimated costs, from thirty days prior to lung transplant up through six months post surgery, exceed 1 million dollars per patient and routine medical costs average approximately fifty thousand dollars per year thereafter.
- Trial name
- LTGO (NCT03728257)
- Testing
- LTGO-Home Based Exercise, Enhanced Usual Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Pittsburgh
Osteoarthritis, Knee, Hypertension
Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and Hypertension
The purpose of the Staying Active with Arthritis (STAR) research study is to determine if a 6-month program will improve leg exercise, fitness walking, and clinical outcomes (function, blood pressure, leg strength, pain, fatigue…
- Trial name
- STAR (NCT01280903)
- Testing
- STAR Intervention, Attention-Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Pittsburgh
Functional Neuroimaging
Sensorimotor Imaging for Brain-Computer Interfaces
The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia.
- Trial name
- NCT04723823
- Testing
- Motor or sensory imagery with fMRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Violence in Adolescence, Social Interaction
Strengthening Adolescent-Adult Networks to Reduce Youth Violence
This pilot community-partnered cluster-randomized trial will examine the feasibility and acceptability of a social network-based youth violence prevention program called Strengthening Connections for Change for youth ages 13-17…
- Conditions
- Violence in Adolescence, Social Interaction, Coping Skills, Adolescent Behavior
- Trial name
- NCT05185453
- Testing
- Strengthening Connections for Change, Job Readiness Training
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease
Optimizing Care for Patients With Dementia
Of the 1.4 million nursing home (NH) residents in long term care facilities, more than half have Alzheimer's disease or dementia.
- Trial name
- NCT03442322
- Testing
- transdisciplinary approach, multidisciplinary approach
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
Risk Reduction
Utilizing Text Messaging to Improve Vehicle Safety Among At-Risk Young Adults
The "Safe Vehicle Engagement (SaVE)" trials are 3 parallel randomized clinical trials that aim to determine the impact of text messaging (SMS) vehicle safety interventions vs.
- Trial name
- SaVE (NCT03833713)
- Testing
- SMS Dialogue, SMS Assessments
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Modeling Multi-level Dyadic Behavior to Transform the Science and Practice of Psychotherapy Process and Outcome.
This is a short-term longitudinal study of psychotherapy process. Participants will be treated with 8 sessions of psychotherapy over the course of 8 to 12 weeks.
- Trial name
- DAPPeR (NCT03594773)
- Testing
- Cognitive Behavioral Therapy, Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Pittsburgh
Down Syndrome
Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR)
This study will examine the feasibility of the Promoting Health through Parent Empowerment and the Activation of Routines (Pro-PEAR) intervention using a open case-series for intervention optimization followed by a pilot RCT in…
- Trial name
- Pro-PEAR (NCT05020366)
- Testing
- Promoting Health through Parent Empowerment and the Activation of Routines, Enhanced Usual Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Pulmonary Hypertension Secondary, Heart Failure
Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
The main objective of this study is to determine the clinical efficacy of oral inorganic nitrite verses placebo and the therapeutic response with regards to exercise tolerance in patients with pulmonary hypertension and heart…
- Trial name
- PH-HFpEF (NCT03015402)
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pittsburgh
Cognitive Aging, Adverse Childhood Experiences
Physical Exercise for Augmenting Cognitive Health (PEACH)
PEACH is a pilot project which is being conducted to determine the feasibility and acceptability of a 12-week home-based exercise intervention among Black and African American adults.
- Trial name
- PEACH (NCT04922710)
- Testing
- Home-based aerobic exercise
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh