Clinical trials: sponsored by University of Pittsburgh
Colon Cancer, Rectum Cancer
Irinotecan and Cetuximab for Colorectal Cancer as Second Line Therapy
Research Hypothesis: Subjects in the study population who are treated with cetuximab in combination with irinotecan will have higher response rates than subjects treated with irinotecan alone.
- Trial name
- NCT00336856
- Testing
- Cetuximab, Irinotecan
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Pittsburgh
Cancer
Safety and Efficacy Study Using Bevacizumab, Capecitabine and Oxaliplatin for Colorectal Cancer
This is a Phase II study of the drug combination of Oxaliplatin, Avastin and capecitabine. This is an open-label study.
- Trial name
- NCT00177307
- Testing
- Bevacizumab, Capecitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Primary Advanced Carcinoma of the Oral Cavity or Oropharynx, Squamous Cell Carcinoma of the Head and Neck
Active Immunization of Patients With Carcinoma of Oral Cavity or Oropharynx With Autologous Dendritic Cells Transfected With DNA From Autologous Tumor
The primary goal of this study is to determine if the vaccine can be safely given to subjects, and to see what side effects occur (both good and bad) when they are given this experimental tumor vaccine.
- Trial name
- NCT00377247
- Testing
- autologous monocyte-derived dendritic cells (DC) transfected with DNA
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Obesity, Overweight
Preference and Vegetarian Diet in Weight Loss Treatment
We propose to add a treatment preference component to a larger study testing standard behavioral treatment (SBT) for weight loss without specific food group restriction vs standard behavioral treatment with gradual elimination of…
- Trial name
- PREFER (NCT00330629)
- Testing
- Standard Behavioral Treatment, SBT+LOV
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Prediabetes, Metabolic Syndrome
Evaluation of Group Lifestyle Balance DVD in Primary Care Practice
The purpose of this study is to examine different methods of delivering the Group Lifestyle Balance (GLB) intervention (1). The GLB is a 12-week lifestyle change program based on the highly successful lifestyle program that was…
- Trial name
- STEPUP (NCT00480779)
- Testing
- GLB Group, GLB DVD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Otitis Media
Effect of Simethicone on Eustachian Tube Dysfunction
This study is designed to measure the effects of a chewable Simethicone tablet taken by mouth on middle-ear pressure in adults with a common cold and evidence of abnormal middle-ear pressure.
- Trial name
- NCT01312038
- Testing
- Simethicone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Contraception
Postplacental or Delayed Insertion of the Levonorgestrel-releasing Intrauterine Device (IUD) After Vaginal Delivery
This study is a randomized controlled trial comparing 6 month usage rates of the levonorgestrel-releasing intrauterine device (LNG-IUD) when inserted postplacentally after vaginal delivery or delayed placement at 6-8 weeks…
- Trial name
- POPI (NCT00476021)
- Testing
- Levonorgestrel-releasing IUD (Mirena)
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes
Evaluation of Group Lifestyle Balance Maintenance Strategies
Heart disease is a leading cause of death in people in the United States. It is a major problem for those with diabetes. Conditions called the metabolic syndrome and pre-diabetes increase risk for diabetes and heart disease.
- Trial name
- NCT00869609
- Testing
- GLB Traditional Maintenance (TM), GLB-Carb-focused Maintenance (CF)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Healthy
Effect of a Proton Pump Inhibitor on Gleevec® in Healthy Volunteers
This is a research study that will investigate the effects of proton pump inhibitors (often used to treat stomach upset) on Gleevec® (a drug that is FDA-approved to treat some types of cancer) in healthy volunteers.
- Trial name
- NCT00446004
- Testing
- Imatinib Mesylate, Omeprazole
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
Effect of Antacids on Gleevec® in Healthy Volunteers
This is a research study that will investigate the effects of antacids (often used to treat stomach upset) on Gleevec® (a drug that is FDA-approved to treat some types of cancer) in healthy volunteers.
- Trial name
- NCT00446316
- Testing
- Antacids (Mg-Al-based), Imatimib Mesylate (Gleevec®)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Allogeneic Blood and Marrow Transplantation (BMT), Graft Versus Host Disease
Pharmacokinetics-based Mycophenolate Mofetil Dosing for GVHD Prevention
Bone marrow transplantation (BMT) is used to successfully treat high-risk forms of leukemia, lymphoma, and other childhood cancers that were once considered incurable.
- Trial name
- NCT01487577
- Testing
- Mycophenolate mofetil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Middle-ear Function
Functional Manifestations of Pressure Changes in the Middle Ear System
This study is looking at whether functional magnetic resonance imaging (fMRI) can see if and when the brain responds to pressure stimulations of the eardrum.
- Trial name
- NCT01932736
- Testing
- changing ear canal pressure
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Lactation, Other Disorders of Bone Density and Structure
Longitudinal Lactation Bone Density Study
Changes in maternal calcium metabolism are necessary during lactation to provide adequate calcium in breast milk for development of the newborn skeleton.
- Conditions
- Lactation, Other Disorders of Bone Density and Structure, Endocrine; Complications
- Trial name
- NCT01630629
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Quality of Life
Temporally-Oriented Subjective Well-being Across Transitions-Resources & Outcomes
As individuals age, they undergo transitions in many aspects of their lives. These transitions include social, economic and health transitions. People review their lives, and reflect on past choices.
- Trial name
- LIFT (NCT01583946)
- Where
- United States
- Volunteers
- 793 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity
Pancreatic Enzymes to Restore Digestive Function in Malnourished Gastric Bypass Patients
Hypothesis: Bypass of the upper GI tract with bariatric surgery results in suppression of pancreatic function resulting in maldigestion and further malabsorption.
- Trial name
- NCT00510744
- Testing
- pancreatic enzyme supplement
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Trichomonas Vaginitis, Chlamydia Trachomatis
Non-Invasive Sexually Transmitted Disease Testing in Women Seeking Emergency Contraception or Urine Pregnancy Testing
The purpose of this study is to determine the prevalence and treatment rates of T. vaginalis, C. trachomatis, and N. gonorrhoeae in women seeking emergency contraception or urine pregnancy testing in the Magee-Womens Hospital…
- Conditions
- Trichomonas Vaginitis, Chlamydia Trachomatis, Neisseria Gonorrhoeae Infection
- Trial name
- NCT00978848
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Von Willebrand Disease
Phase II Study of IL-11 (Neumega) in Von Willebrand Disease
This study is testing the use of rhIL-11 (recombinant interleukin 11, Neumega) in individuals with Von Willebrand disease. The purpose is to evaluate: 1. if rhIL-11 corrects VWF (Von Willebrand Factor) levels to normal 2.
- Trial name
- NCT00151125
- Testing
- recombinant interleukin-11
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pittsburgh
Lateral Epicondylitis, Tennis Elbow
Prolotherapy for the Treatment of Chronic Lateral Epicondylitis
Lateral epicondylitis (LE), or tennis elbow, is a common and often disabling condition affecting young and middle-aged adults-most commonly manual workers and recreational athletes.
- Trial name
- NCT00674622
- Testing
- Prolotherapy
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Pittsburgh
Lung Diseases, Bronchopulmonary Dysplasia
Prolonged Outcomes After Nitric Oxide (PrONOx)
The purpose of this study is to look at the long term consequences of prematurity in infants treated with inhaled nitric oxide (iNO) while in the neonatal intensive care unit.
- Conditions
- Lung Diseases, Bronchopulmonary Dysplasia, Premature Birth, Developmental Disabilities
- Trial name
- NCT00234247
- Testing
- Long Term Follow-Up
- Volunteers
- 652 people
- Sponsor
- University of Pittsburgh
Breast Cancer
The Effect of Aromatase Inhibitors on Cardiovascular Risk Factors in Women With Breast Cancer
This study explores how aromatase inhibitor therapy affects risk factors for heart disease in postmenopausal women with breast cancer.
- Trial name
- Silhouette (NCT01080170)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh