Clinical trials: sponsored by University of Rochester
End Stage Renal Disease, Chronic Kidney Diseases
Shared Decision Making in Dialysis
Older patients ≥65 years with chronic kidney disease (CKD) face challenges in decision making about dialysis. These patients report little effort by physicians to elicit treatment preferences, discuss prognoses, or explain the…
- Trial name
- DIAL-SDM (NCT04392440)
- Testing
- DIAL-SDM, usual care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Rochester
Smoking, Smoking Cessation
Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
The purpose of this randomized controlled trial is to assess the efficacy of Actívatexto (Aim 1) and the mediators of the presumed treatment effect (Aim 2) among Latino adults who smoke.
- Conditions
- Smoking, Smoking Cessation, Physical Inactivity
- Trial name
- NCT06926608
- Testing
- Actívatexto, Decídetexto
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- University of Rochester
DLBCL, Lymphoma, B-Cell
A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL
The purpose of this study is to test the effectiveness and safety of polatuzumab vedotin in combination with R-miniCHP in patients 75 years and older with DLBCL.
- Trial name
- NCT04594798
- Testing
- Polatuzumab vedotin, Rituximab, Cyclophosphamide
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Rochester
Pulmonary Embolism
Home Rehabilitation After Acute Pulmonary Embolism
The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care.
- Trial name
- NCT05571189
- Testing
- Daily Activity Text, Control Text
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Rochester
Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN)
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants…
- Conditions
- Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy
- Trial name
- NCT06614322
- Testing
- Pregabalin, Duloxetine
- Where
- 7 sites in United States
- Volunteers
- 190 people
- Sponsor
- University of Rochester
Multiple Myeloma
Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma
The purpose of this study is to determine the effects of daratumumab and lenalidomide without steroids for treating patients with multiple myeloma.
- Trial name
- NCT04635189
- Testing
- Daratumumab, Lenalidomide, Dexamethasone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Rochester
Alcohol Use Disorder, Retinal Dystrophies
The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner…
- Conditions
- Alcohol Use Disorder, Retinal Dystrophies, Age-Related Macular Degeneration, Retinitis Pigmentosa
- Trial name
- NCT06319872
- Testing
- Oral disulfiram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester
Myeloid Malignancy, Acute Myeloid Leukemia
A Telehealth Advance Care Planning Intervention
The objective of this project is to conduct a pilot randomized trial to assess the preliminary efficacy of a telehealth-delivered Serious Illness Care Program on healthcare communication, patient anxiety and distress, as well as…
- Conditions
- Myeloid Malignancy, Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm
- Trial name
- SICP RCT (NCT05875805)
- Testing
- Telehealth Serious Illness Care Program, Education Control
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Rochester
Cancer
Exercise and Cognitive Rehab in Older Cancer Survivors
The objective of the study is to evaluate the feasibility of a combined mobile health exercise and cognitive rehabilitation intervention and its effect on cognition in a single-arm pilot study that recruits cancer survivors.
- Trial name
- E-Co (NCT05388214)
- Testing
- E-Co
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Breathing, Lung Function Decreased
Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function
This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.
- Conditions
- Breathing, Lung Function Decreased, MRI Imaging, Healthy
- Trial name
- PROOF (NCT07614685)
- Testing
- Airway Oscillometer, Phase Resolved Functional Lung MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Disease (DED)
BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber
The purpose of this study is to evaluate the short-term effects (impact on tear film and dry eye symptoms) of the BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber (the device under investigation) in individuals…
- Trial name
- NCT07430735
- Testing
- BriTer Eyez Moisture Vue™ On Demand Disposable Moisture Chamber
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Rochester
Cancer
A Single Arm Pilot Trial of a Social Network Intervention
The purpose of this study is to see if a social network support program (SOcial Networks to Activate Trust \& Adherence or SONATA) is helpful for older individuals receiving cancer treatment.
- Trial name
- SONATA (NCT05745038)
- Testing
- SONATA
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Rochester
Vision Loss Partial, Vision; Loss, Both Eyes
Effect of Visual Retraining After Stroke
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and…
- Conditions
- Vision Loss Partial, Vision; Loss, Both Eyes, Hemianopia Homonymous, Hemianopia
- Trial name
- urochester (NCT06121219)
- Testing
- Training in the Blind Field
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cancer
Exercise and Cognitive Rehabilitation Interventions for Older Cancer Survivors
The objective of this study is to assess the preliminary effects of an integrated exercise and cognitive rehabilitation intervention (ECO), an exercise intervention (EXCAP), and a cognitive rehabilitation intervention (MAAT) as…
- Trial name
- ECO 2 (NCT07390045)
- Testing
- EXCAP, MAAT, ECO
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Fatigue, Inflammation
Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer
To determine the feasibility of an 8-week fucoidan supplement intervention for patients with fatigue post-cancer treatment and assess changes in fatigue, frailty, and inflammation.
- Trial name
- NCT06295588
- Testing
- Fucoidan extracted from F. Vesiculosus, Fucoidan extracted from U. Pinnatifida
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Fetal Alcohol Spectrum Disorders
Families Moving Forward (FMF) Connect Pro for Mental Health Providers
The goal of this clinical trial is to test a new provider-assisted version of the caregiver Families Moving Forward (FMF) Connect app ("FMF Connect Pro") with mental health providers in the United States.
- Trial name
- NCT05960461
- Testing
- FMF (Families Moving Forward) Connect Pro, ECHO (Extension of Community Healthcare Outcomes) implementation., Self-Directed Learning implementation.
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Rochester
End-stage Heart Failure
Echocardiographic Assessment of the Effect of Impella on Biventricular Function
The objective of this prospective observational study is to evaluate the effects of Impella 5.5 on biventricular function in adult patients with end-stage heart failure requiring temporary mechanical circulatory support.
- Trial name
- NCT07534462
- Testing
- Echocardiographic Assessment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester
Thyroglossal Duct Cysts
Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain
Purpose of the Study: This study looks at how kids recover after a type of neck surgery called the Sistrunk procedure. Some kids have a small tube (called a drain) placed during surgery, and some do not.
- Trial name
- NCT07148895
- Testing
- Post-surgical drain, No post-surgical drain
- Where
- 5 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Rochester
Insomnia, Harmful; Use, Alcohol
Adapting CBT-I for Hazardous Alcohol Users
The goal of this intervention development trial is to develop, refine, and test a telephone-delivered, 4-session version of cognitive behavioral therapy for insomnia adapted to hazardous alcohol users with co-occurring insomnia.
- Trial name
- NCT05973955
- Testing
- Insomnia Treatment, Education Control
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Posttraumatic Stress Disorder
Resilient Roots: Supporting Youth and Families
Resilient Roots is integrated into the TRANSFORM Center to promote translation of research findings into clinical interventions, to inform the next generation of research on child abuse and neglect (CAN), and to facilitate…
- Trial name
- NCT06535516
- Testing
- Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Socialization (S)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester