Clinical trials: sponsored by University of Rochester
Suicide, Attempted
Study About Treatment After a Suicide Attempt
Effective, brief, low-cost interventions for individuals who attempt suicide are needed to save lives and achieve the goals of the National Strategy for Suicide Prevention.
- Trial name
- NCT03894462
- Testing
- Attempted Suicide Short Intervention Program, Zero Suicide Usual Care
- Where
- 3 sites in United States
- Volunteers
- 443 people
- Sponsor
- University of Rochester
Crisis Response Plan, Crisis Intervention
Reducing Crises and Suicide Within the Idaho Army National Guard
Military suicide is an ongoing public health concern, particularly within the Army National Guard (ARNG), with longstanding effects on fellow soldiers, family, and friends.
- Trial name
- NCT07032636
- Testing
- Crisis Intervention - The First Line Leaders (FLL) program will utilize templated guides developed with stakeholders from the Idaho Army National Guard (ARNG), known as the Total Health Action Plan (T
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Frailty, Inflammation
Reducing Frailty for Older Cancer Survivors Using Supplements II
This study is a two-arm placebo controlled randomized clinical trial, to assess the effect of a 12-week EGCG intervention on physical frailty compared to placebo in pre-frail older cancer survivors.
- Trial name
- ReFOCUS2 (NCT06068543)
- Testing
- Epigallocatechin-3-Gallate (EGCG), Microcrystalline cellulose (MCC), Ascorbic Acid (Vitamin C)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Rochester
Depression - Major Depressive Disorder, Anxiety
Deaf CBT-TS to Reduce Suicide Risk
The goal of this clinical trial is to learn if a short, Zoom-based intervention, Cognitive Behavioral Therapy for Treatment-Seeking for Deaf Individuals (Deaf CBT-TS) can change beliefs about mental health treatment and increase…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia
- Trial name
- NCT07279363
- Testing
- Deaf CBT-TS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
Smoldering Multiple Myeloma
Denosumab for Smoldering Multiple Myeloma
This study will assess the safety and tolerability of denosumab in smoldering multiple myeloma subjects as well to see if denosumab can reduce subjects' risk of getting multiple myeloma.
- Trial name
- NCT03839459
- Testing
- Denosumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
HIV Prevention and Care
Lafiya HIV Self-testing Study Protocol
The study aims to address low testing and related issues such as stigma, low-risk perception, and concerns about confidentiality affecting testing.
- Trial name
- NCT06238323
- Testing
- LAFIYA
- Where
- Ghana
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cancer
Dyadic Life Review Intervention for Older Patients With Advanced Cancer) and Their Caregivers
The purpose of this study is to test the feasibility of a pilot Randomized Controlled Trial (RCT) comparing Dyadic Life Review (DLR) intervention in older adults with advanced cancer and their caregivers to Care-as-Usual (CAU)…
- Trial name
- DLR RCT (NCT06505122)
- Testing
- Dyadic Life Review
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
HIV Prevention and Care
Lafiya HIV-status Neutral Study - Protocol
The primary objective of this study is to adapt and evaluate the feasibility of "Lafiya," which means "Wellness" in Hausa, a multilevel intersectional stigma \& discrimination (ISD) and HIV testing intervention, to a…
- Trial name
- NCT06312514
- Testing
- LAFIYA
- Where
- Ghana
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester
Disease/Condition Name Cancer-related Cognitive Dysfunction, Chronic Lymphocytic Leukemia (CLL)
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
This study examines whether there are differences in brain health or well-being in patients receiving TKI therapy for leukemia compared to individuals who do not receive TKI therapy.
- Conditions
- Disease/Condition Name Cancer-related Cognitive Dysfunction, Chronic Lymphocytic Leukemia (CLL), Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Trial name
- TKI (NCT07638007)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Rochester NCORP Research Base
Nausea and Vomiting Chemotherapy-Induced
Medical Cannabis Observational Study for Antiemetic Intervention in Chemotherapy
The goal of this observational study is to evaluate the associations between patient-directed medical cannabis use and chemotherapy-induced nausea and vomiting (CINV), as well as other treatment-related symptoms, among patients…
- Trial name
- MOSAIC (NCT07374939)
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Breast Cancer With Low to Intermediate HER2 Expression
Optimization of Cardiac Imaging in Women With Early-Stage Breast Cancer
The purpose of this study is to determine whether a personalized, risk-stratified surveillance strategy can safely reduce unnecessary cardiac imaging while preserving early detection of treatment-related cardiotoxicity in women…
- Trial name
- POCEB (NCT07630402)
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Myotonic Dystrophy Type 1, Congenital DM1
Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic Dystrophy
Myotonic dystrophy type 1 (DM1) can affect people in many different ways, even in the same family. The symptoms that children experience can be different and more severe than adults.
- Conditions
- Myotonic Dystrophy Type 1, Congenital DM1, Juvenile DM1, Childhood DM1
- Trial name
- REACH-DM KIDS (NCT07630389)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Advanced Rectal Cancer
Neoadjuvant FOLFOX Therapy With Short Course Radiation and Active Surveillance in Locally Advanced Rectal Cancer
The purpose of this study is to evaluate the treatment of patients with locally advanced rectal cancer for complete response to neoadjuvant chemotherapy without the use of radiation and surgery.
- Trial name
- NCT03781323
- Testing
- FOLFOX
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Sickle Cell Disease (SCD)
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therapies (NT-DMT) for pediatric…
- Trial name
- WeDecide (NCT06941389)
- Where
- 37 sites in United States, Canada
- Volunteers
- 480 people
- Sponsor
- University of Rochester
Low Milk Supply
Facilitating Lactation Through Optimized Workflows - Evaluating the Efficiency of Pumping Protocols and Cellular Mechanisms of Milk Production
The purpose of this study is to evaluate the effectiveness of two different breast pumping protocols in increasing milk production among lactating individuals diagnosed with primary low milk supply, and to investigate the…
- Trial name
- FLOW (NCT07260968)
- Testing
- Pumping frequency intervention
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Non-small Cell Lung Cancer
Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2
The purpose of this study is to understand if treatment with one chemotherapy medication combined with immune therapy (pembrolizumab) is tolerable and effective for patients with lung cancer and performance status of 2 (PS2)…
- Trial name
- NCT04297605
- Testing
- Pembrolizumab, Pemetrexed (Chemotherapy), Nab-paclitaxel (Chemotherapy)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Mild Cognitive Impairment, Healthy Aging
Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE)
A recently completed study suggested that processing speed and attention (PS/A) oriented cognitive training (VSOP) produced robust effect on PS/A and working memory, but not in cognitive control or episodic memory, and long-term…
- Trial name
- NCT04522791
- Testing
- RFB, VSOP, IR
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University of Rochester
Brain Tumor
Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas
The purpose of this study is to determine whether the study medication, brivaracetam, is tolerable and safe for patients with brain tumors.
- Trial name
- NCT05029960
- Testing
- Brivaracetam
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Rochester
Cardiomyopathies, Heart Failure
Factors Associated With Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Non-LBBB ECG Pattern
Cardiac resynchronization therapy with a defibrillator (CRT-D) in heart failure (HF) patients without left bundle branch block (non-LBBB) has been less beneficial to improve outcomes despite being a guideline indicated therapy…
- Conditions
- Cardiomyopathies, Heart Failure, Non-left Bundle Branch Block, Cardiac Resynchronization Therapy
- Trial name
- FACT-CRT (NCT06977217)
- Testing
- CRT-D implantation
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Rochester
Breathing, Mouth, Lung Function Decreased
Cardiopulmonary Exercise Testing and Oscillometry for the Evaluation of Dyspnea
This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on Cardiopulmonary Exercise Testing in subjects who are experiencing shortness of breath.
- Conditions
- Breathing, Mouth, Lung Function Decreased, Dyspnea, Shortness of Breath
- Trial name
- COED (NCT06554353)
- Testing
- Oscillometer
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester