Clinical trials: sponsored by University of Rochester
Brain Tumor
Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas
The purpose of this study is to determine whether the study medication, brivaracetam, is tolerable and safe for patients with brain tumors.
- Trial name
- NCT05029960
- Testing
- Brivaracetam
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Rochester
Parkinson Disease
Wearable Assessments in the Clinic and Home in PD
The purpose of this study is to evaluate disease progression in persons with early Parkinson disease, as assessed by digital and electronic sensor data collection to be correlated with typical clinical assessments.
- Trial name
- WATCH-PD (NCT03681015)
- Where
- 17 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hpv
Stand Up 2 HPV: Standing Orders to Improve HPV Vaccination
Each year in the U.S., ≥20,000 women and 14,000 men are affected by HPV-related cancers, including cervical and oropharyngeal cancer. However, in 2020, only 59% of U.S.
- Trial name
- NCT06380114
- Testing
- Communication, Standing Orders
- Where
- United States
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Aging, Premature
Study of Neurological Aging Among People Living With HIV
A prospective, exposure-control cohort study of older adults living with HIV comparing the neurological status of those who have had HIV infection for a longer period of time (long HIV group) to age, gender, and community-matched…
- Trial name
- SNAP (NCT05678660)
- Where
- 3 sites in Zambia
- Volunteers
- 298 people
- Sponsor
- University of Rochester
Rheumatoid Arthritis
Imaging of Lymphatic Vessels in People With Rheumatoid Arthritis (RA)
Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities.
- Trial name
- NCT05197530
- Testing
- Indocyanine green, MultiSpectral Imaging System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Metastatic Breast Cancer
Evaluation of a Patient-Centered Decision-Making Support Tool for Older Adults With Advanced Breast Cancer and Their Care Partners
The purpose of this study is to determine the feasibility for a patient centered decision-making support tool for older adults with metastatic breast cancer and their care partners.
- Trial name
- PCDM (NCT07599618)
- Testing
- Decision-making support tool
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Rochester
Schizophrenia, Bipolar Disorder
Rochester Forensic Assertive Community Treatment Model in Minnesota
This study evaluates the Rochester Forensic Assertive Community Treatment (R-FACT) model in Minnesota. R-FACT is an enhanced version of Assertive Community Treatment designed to support individuals with serious mental illness who…
- Conditions
- Schizophrenia, Bipolar Disorder, Criminal Behavior
- Trial name
- R-FACT (NCT07592884)
- Testing
- R-FACT intervention, Standard Outpatient Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Heart Failure
Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized-controlled trial compares two treatment strategies in high-risk ischemic cardiomyopathy (ICM) patients referred for primary ICD implantation.
- Trial name
- PREVENT-VT (NCT06543173)
- Testing
- Prophylactic Catheter-based VT Ablation
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Brain Tumor Adult
A Study of Cognitive Changes in Patients Receiving Brain Radiation
Cranial radiation therapy (RT), commonly used to treat benign and malignant brain tumors, can lead to cognitive impairments in domains not related to neuroanatomic structures directly impacted by the tumor.
- Trial name
- NCT04390906
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Rochester
Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4
Safety, Feasibility and Efficacy of Sulforaphane (Avmacol Extra Strength) in Chronic Kidney Disease
The Sulforaphane Production System® in Avmacol Extra Strength (ES) supplies broccoli seed extract (glucoraphanin) and Myrosimax® (Active Myrosinase Enzyme) which helps promote sulforaphane production in your body.
- Trial name
- NCT05797506
- Testing
- Sulforaphane (Avmacol Extra Strength)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Rochester
Chronic Pain
The Role of Brain Dopamine in Chronic Pain
Chronic pain is associated with plasticity in the brain limbic system composed mainly of the amygdala, hippocampus, ventral striatum, and cingulate cortex (ACC) /medial prefrontal cortex (mPFC).
- Trial name
- NCT05285683
- Testing
- Methylphenidate, carbidopa-levodopa
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Alzheimer Disease, Dementia
Tele-Savvy for Latino Caregivers
Latino caregivers of individuals with Alzheimer's disease and related dementias experience high levels of stress burden and depressive symptoms and are underrepresented in caregiver intervention research.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Stress
- Trial name
- NCT07290387
- Testing
- Tele Savvy for Latino Caregivers
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Rochester
Pregnant and Parenting Women
Promotion of Successful Parenting
Home visitation by community health workers is a commonly utilized approach to support families and prevent child maltreatment. At times, however, more intensive intervention is needed to address familial trauma, depression, or…
- Trial name
- PROMISE (NCT03808987)
- Testing
- Child-Parent Psychotherapy (CPP), Community Health Worker (CHW) home visitation
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Asthma in Children
Telemedicine Enhanced Asthma Management - Uniting Providers for Teens (TEAM-UP for Teens)
Low-income, minority teenagers have disproportionately high rates of asthma morbidity, including excess risk of emergency department visits, hospitalizations, and death from asthma.
- Trial name
- NCT04089046
- Testing
- TEAM-UP for Teens, Enhanced Care (EC)
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- University of Rochester
Stress Incontinence Female, Urinary Incontinence
TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
This will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence.
- Conditions
- Stress Incontinence Female, Urinary Incontinence, Urinary Incontinence,Stress, Pain
- Trial name
- TENSUB (NCT06369922)
- Testing
- TENS, Control TENS
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Prostate Cancer, Multiple Myeloma
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
To explore the use of curcumin and piperine supplementation at a dose of 4 gram/5mg twice a day in early stage prostate cancer patient undergoing active surveillance or patients on observation for MGUS/ low-risk smoldering…
- Conditions
- Prostate Cancer, Multiple Myeloma, Smoldering Multiple Myeloma (SMM), Monoclonal Gammopathy of Undetermined Significance
- Trial name
- NCT04731844
- Testing
- Curcumin plus Piperine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Heart Failure With Reduced Ejection Fraction
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
The investigators aim to compare the risk of mortality of Non-implantable carioverter defibrillator (ICD) vs. ICD management in patients with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- CONTEMP-ICD (NCT06543446)
- Testing
- ICD implantation
- Where
- 15 sites in United States, Canada
- Volunteers
- 3,290 people
- Sponsor
- University of Rochester
Acute Myeloid Leukemia
A Patient-Centered Communication Tool (UR-GOAL) Versus Usual Care for Older Patients With Acute Myeloid Leukemia, Their Caregivers, and Their Oncologists
The objective of this study is to evaluate the preliminary efficacy of the UR-GOAL tool in improving shared decision making and communication between older patients with AML and their oncologists in a pilot randomized trial.
- Trial name
- UR-GOAL 2 (NCT05335369)
- Testing
- UR-GOAL
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Rochester
Advanced Renal Cell Carcinoma
Software Monitoring of Treatment Related Toxicities in Advanced Renal Cell Carcinoma
To determine if Carevive software, which monitors treatment-related toxicities and then generates self-care management plans for these symptoms, will be feasible to implement among patients with metastatic renal cell carcinoma…
- Trial name
- NCT03229083
- Testing
- Carevive software
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Rochester
Frailty, Inflammation
Reducing Frailty for Older Cancer Survivors Using Supplements
The purpose of the study is to examine the feasibility and safety of twelve weeks oral supplementation of Epigallocatechin-3-gallate (EGCG) in older survivors of cancer
- Trial name
- ReFOCUS1 (NCT04553666)
- Testing
- Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester