Clinical trials: sponsored by University of Southern Denmark
Diabetes Mellitus, Type 2
Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes
Type 2 diabetes is a major public health concern. It is widely established that type 2 diabetes in linked to activated innate immunity and increased levels of C-reactive protein and interleukin-6 (IL-6) in plasma.
- Trial name
- NCT04504045
- Testing
- Metformin, Caffeine, Efavirenz
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Southern Denmark
Cerebral Palsy
Cerebral Palsy & Predictors of Physical Activity
Children and adolescents with cerebral palsy may be trapped in a vicious circle of low physical fitness, early fatigue in daily activities, resulting in deconditioning and a further decrease in physical activity.
- Trial name
- NCT04614207
- Where
- Denmark
- Volunteers
- 123 people
- Sponsor
- University of Southern Denmark
Hypertension, Pulmonary Arterial, Out-Of-Hospital Cardiac Arrest
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)
Background: For patients with out-of-hospital cardiac arrest (OHCA) at the intensive care unit (ICU), oxygen therapy plays an important role in post resuscitation care.
- Conditions
- Hypertension, Pulmonary Arterial, Out-Of-Hospital Cardiac Arrest, Intensive Care Unit, Oxygen Therapy
- Trial name
- RELIEPH (NCT05029167)
- Testing
- Restrictive PaO2, Low normal MAP, Liberal PaO2
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Southern Denmark
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Feasibility Studies
Reduction of Screen-Based Media Use in Families With Children
The purpose of this pilot experiment is threefold. 1. To assess the efficacy of the recruitment strategy 2. To assess the acceptability and feasibility of the outcome measurement methods obtained in free-living in the…
- Trial name
- NCT03788525
- Testing
- Reduced recreational screen time, Timed recreational screen time
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Chronic Ankle Instability
Elite Athletes With Chronic Ankle Instability Using Spraino®: A Cohort Study
Fear of re-injury and deficiencies in ankle joint function are common conditions amongst high performance (elite) athletes with chronic ankle instability (CAI), who participate in indoor sports.
- Trial name
- NCT03706729
- Testing
- Spraino
- Where
- 2 sites in Denmark
- Sponsor
- University of Southern Denmark
Extrapulmonary Tuberculosis, Tuberculosis, Pulmonary
POC Strategies to Improve TB Care in Advanced HIV Disease
Tuberculosis (TB) remains the major cause of morbidity and mortality among patients with HIV. Sub-optimal diagnostics contributes towards poor patient outcome and there is an urgent need to identify non-sputum-based point-of-care…
- Conditions
- Extrapulmonary Tuberculosis, Tuberculosis, Pulmonary, Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome
- Trial name
- TBPOC (NCT04122404)
- Testing
- LF-LAM
- Where
- 3 sites in Ghana
- Volunteers
- 425 people
- Sponsor
- University of Southern Denmark
Risk Communication, Cardiovascular Risk Factor
Danish Evaluation of Your Heart Forecast.
Under 50% of patients diagnosed with hypertension and treated in general practice, have reached a blood pressure within the recommended levels of the national guideline.
- Trial name
- DANY (NCT04058847)
- Testing
- Your Heart Forecast
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- University of Southern Denmark
Adult Depression
Blended Cognitive Behavioural Therapy Versus Face-to-face Cognitive Behavioural Therapy
Depression is a prevalent and disabling disorder with great cost to the individual and the society. Lately, the use of internet interventions as guided self-help has demonstrated remarkable results.
- Trial name
- NCT02796573
- Testing
- cognitive behavioural therapy
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Southern Denmark
Out-Of-Hospital Cardiac Arrest
International Termination of Resuscitation Practices
Neither the international nor the interregional variation in survival following OHCA is fully understood, but may rely on multiple factors such as: organization of the Emergency Medical Service (EMS) system bystander…
- Trial name
- NCT05029180
- Testing
- Termination of resuscitation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Hirschsprung Disease
Full Thickness vs. Rectal Suction Biopsy in the Diagnosis of Hirschsprungs Disease
The objective of this prospective study is to compare the diagnostic accuracy of rectal suction biopsy (RSB) compared to full thickness rectal biopsy (FTB) in the diagnosis of Hirschsprungs Disease (HD) in children.
- Trial name
- BIOPSY (NCT05307419)
- Testing
- Rectal suction biopsy., Full-thickness rectal biopsy.
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Southern Denmark
Empowerment, Cervical Cancer, Endometrial Cancer, Follow-up, Nurse-led, PROM
An Individualised and Patient-centred Follow-up Program for Women With Gynaecological Cancer
This randomized controlled trial is testing the hypothesis that an individually focused and need-based nurse led follow-up program supported by electronic Patient Reported Outcome Measures for women with gynecological cancer will…
- Trial name
- NEMO (NCT03838861)
- Testing
- NEMO: NEw MOdel of follow-up
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Southern Denmark
Multiple Sclerosis
Muscle Strain in Multiple Sclerosis Patients Measured by Ultrasound Speckle Tracking Technique
The primary study, as outlined in the original trial registration, aiming to use ultrasound speckle tracking (STU) to monitor muscle contractility in multiple sclerosis (MS) patients receiving vs.
- Trial name
- MUST (NCT03847545)
- Testing
- Fampridine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- University of Southern Denmark
Tear of Meniscus of Knee
Danish Rct on Exercise Versus Arthroscopic Meniscal Surgery for Young Adults
There are two cartilage structures in each knee joint called a meniscus. A torn meniscus can be caused by either a smaller or larger trauma or be a degenerative age-related tear.
- Trial name
- DREAM (NCT02995551)
- Testing
- Arthroscopic meniscal repair or resection, Exercise and education
- Where
- 7 sites in Denmark
- Volunteers
- 122 people
- Sponsor
- University of Southern Denmark
Healthy Volunteers, Drug Drug Interaction
Flucloxacillin as an Inducer of CYP-enzymes
Worldwide there is an increase in antibiotic resistance which may have potential fatal long-term consequences. This is due to extensive use and sometimes misuse of antibiotics in the treatment of harmless infections.
- Trial name
- NCT04840641
- Testing
- Flucloxacillin
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
ARDS Due to COVID-19
Ventilator Strategies in ICU Patients With COVID-19 - a National-wide Retrospective Observational Study.
Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events.
- Trial name
- NCT05102630
- Where
- 2 sites in Denmark
- Volunteers
- 1,193 people
- Sponsor
- University of Southern Denmark
Alcohol Use Disorders
Exposure Therapy as Aftercare for Alcohol Use Disorder
Background: It is well documented that individuals with Alcohol Use Disorder (AUD) respond well during evidence-based psychological treatment, but also that a large proportion relapse when discharged from treatment and confronted…
- Trial name
- NCT02298751
- Testing
- Cue Exposure Treatment
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- University of Southern Denmark
Multiple Sclerosis, Neurodegeneration
Central and Peripheral Nervous System Changes as Markers of Disease Progression in Multiple Sclerosis
OBJECTIVE To investigate neurodegeneration and demyelination in the central and peripheral nervous system in multiple sclerosis linked to disease progression and mechanisms that can explain different responses to Fampridine…
- Conditions
- Multiple Sclerosis, Neurodegeneration, Central Nervous System Lesion, Peripheral Nervous System Problem
- Trial name
- NCT03401307
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- University of Southern Denmark
Renal Failure
Music Interventions for Patients Undergoing Hemodialysis
Fatigue is found to be one of the most persistent problems among patients in treatment with hemodialysis, and associated with impaired health-related quality of life.
- Trial name
- NCT04959682
- Testing
- Music Intervention
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Southern Denmark
Alcohol Drinking
High Schools- High on Life: an Intervention to Reduce Excessive Drinking in Danish High Schools
High schools High on life' intervention is a high school-based, multi-component intervention guided by theory, evidence, and empirical findings to reduce excessive drinking among Danish high school students.
- Trial name
- NCT03906500
- Testing
- High schools High on Life
- Where
- Denmark
- Volunteers
- 3,682 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark