Clinical trials: sponsored by University of Utah
Marginal Zone Lymphoma
Pirtobrutinib in Combination With Rituximab in Adults With Untreated Marginal Zone Lymphoma (PIONEER-MZL)
The purpose of this clinical trial is to learn if the drugs Pirtobrutinib and Rituximab are effective for the treatment of newly diagnosed marginal zone lymphoma.
- Trial name
- NCT06390956
- Testing
- Pirtobrutinib, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Utah
Chronic Lymphocytic Leukemia, Non-melanoma Skin Cancer (NMSC)
Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin Cancers
This is a randomized, phase II, double-blind, placebo-controlled trial with planned crossover to the intervention arm after 1 year.
- Trial name
- NCT04844528
- Testing
- Nicotinamide
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Utah
Cutaneous Melanoma, Brain Metastases
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma
The goal of this interventional clinical trial is to provide proof-of-principle data for the biologic activity of defactinib in combination with avutometinib in brain metastases from melanoma, and to define the potential role of…
- Trial name
- DETERMINE (NCT06194929)
- Testing
- Defactinib, Avutometinib, Encorafenib
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Utah
Cancer, Smoking
Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type
The purpose of this research study is assess feasibility and acceptability of a recently developed brief self-help intervention targeted by cancer type to increase motivation to quit smoking.
- Trial name
- NCT06484179
- Testing
- Targeted Self-Help, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Breast Cancer, Opioid Use
The Impact of Intraoperative Methadone on Postoperative Opioid Use
This is a single-institution, randomized controlled trial to assess the effectiveness of intraoperative methadone on postoperative opioid use, pain control, and recovery in patients undergoing autologous breast reconstruction.
- Trial name
- NCT07092475
- Testing
- Methadon
- Where
- United States
- Sponsor
- University of Utah
Migraine Disorders
Emotional Awareness and Expression Therapy (EAET) as a Novel Migraine Treatment
This study tests the effect of a new behavioral intervention, Emotional Awareness and Expression Therapy (EAET), as a possible new treatment for people living with migraine.
- Trial name
- EAET (NCT05837650)
- Testing
- Emotional Awareness and Expression Therapy (EAET)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Breast Reconstruction, Breast Cancer
SAVE Trial: SAfe Opioid Use Video Education
The study will assess the efficacy of a standardized postoperative patient-centered intervention designed to educate patients on the opioid epidemic, the judicious use of opioids, and the proper disposal of opioids.
- Trial name
- SAVE (NCT07044583)
- Testing
- Opioid Educational Video
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Utah
Weight Loss, Weight Gain
Eating Mindfully to Prevent Weight Regain
The overall objective of this study is to evaluate the efficacy of a mindfulness-based intervention to prevent weight regain in weight-reduced adults.
- Conditions
- Weight Loss, Weight Gain, Eating Behavior, Obesity
- Trial name
- EMPWR (NCT04847843)
- Testing
- Mindfulness Orientated Recovery Enhancement, Control Intervention
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Utah
Breast Cancer
Enhancing Mammography Programs for Outreach, Wellness, Education, and Resources (EMPOWER) in Underserved Populations Study
This study is investigating the feasibility of a digital tool called a chatbot for providing educational information about mammography through a tablet, computer, or phone.
- Trial name
- EMPOWER (NCT07029490)
- Testing
- Chatbot
- Where
- United States
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- University of Utah
Total Joint Arthroplasty
Measuring Postoperative Mobility, Gait Symmetry and Feedback Following TJA
The objectives of this study are: 1. The investigators plan to evaluate and validate the use of a novel wireless insole device (Loadsol) that provides real-time biofeedback on post-operative mobility and weight bearing following…
- Trial name
- NCT03673293
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Utah
Osteoarthritis
Outcomes Following Total Knee Arthroplasty
The purpose of this investigation is to determine both patient-reported and performance-based outcomes, specifically muscle function and kinematic/kinetic outcomes, between four different surgical total knee prostheses in…
- Trial name
- NCT02364011
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Utah
Platelet-Rich Plasma (PRP), Knee Osteoarthritis (OA)
Validation of a Low-cost Platelet-Rich Plasma (PRP)
Knee osteoarthritis is an extremely common and debilitating condition, more common in women, with an estimated global prevalence of 16%, and as high as 50% by the age of 80.
- Trial name
- PRP (NCT06184048)
- Testing
- Intra-Articular knee injection of LC-PRP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Type 1 Diabetes
FAMS-T1D Self-Regulation and Social Support for T1D
The goal of this clinical trial is to evaluate how effective the FAMS-T1D intervention is for improving self-regulation (e.g., setting and meeting goals for type 1 diabetes) and social support for meeting those goals for young…
- Trial name
- FAMS-T1D (NCT05820477)
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Utah
Knee Osteoarthritis
New Options for Treating Knee Osteoarthritis Pain
This study will be a single-site, four-arm, randomized, placebo-controlled clinical trial. Knee osteoarthritis patients (N=164) will be randomized to Reiki, Sham Reiki (placebo control), mindfulness meditation (active control)…
- Trial name
- NCT05541718
- Testing
- Reiki, Mindfulness Meditation
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Utah
Herpes Simplex Oral
EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions
This will be a randomized, efficacy assessor-blinded, parallel group, pilot study of up to 20 subjects with documented herpes labialis.
- Trial name
- NCT04893577
- Testing
- EDTA, Abreva
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Diabetes, Weight Loss
Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care for Our Program
Many people struggle not only to lose weight through changes in diet and physical activity, but also to maintain weight loss once they have achieved it.
- Conditions
- Diabetes, Weight Loss, Diet Habit
- Trial name
- MAINTAIN PRIME (NCT04420936)
- Testing
- MAINTAIN PRIME Lifestyle Coaching, Control tracking
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- University of Utah
Hiv, Stigmatization
Simulation Training for Labor and Delivery Providers to Address HIV Stigma During Childbirth in Tanzania
This study will work in Tanzania to develop and pilot test a simulation and experiential learning intervention for labor and delivery providers, in order to address HIV stigma during childbirth.
- Conditions
- Hiv, Stigmatization, Pregnancy Related
- Trial name
- NCT05271903
- Testing
- MAMA Intervention
- Where
- Tanzania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Utah
Colonic Cancer
Evaluating Online Messages About Colon Cancer Screening
The goal of the study is to determine, using a choice-based approach, what messages (pulled from various online sites) people find more and less persuasive and shareable on the topic of colorectal cancer screening.
- Trial name
- NCT06134089
- Testing
- Perceived Effectiveness Prompt, Perceived Shareability Prompt
- Where
- United States
- Volunteers
- 2,210 people, healthy volunteers welcome
- Sponsor
- University of Utah
Skin Cancer, Adolescents
Sun-safe Habits Intervention and Education
The purpose of this study is to determine the efficacy of the Sun-safe Habits Intervention and Education (SHINE) intervention in improving sun protection use and decreasing intentional tanning among high school students.
- Trial name
- SHINE (NCT04341064)
- Testing
- SHINE Intervention
- Where
- United States
- Volunteers
- 2,223 people, healthy volunteers welcome
- Sponsor
- University of Utah
Breast Cancer, Gynecologic Cancer
Guided Meditation During Radiation Therapy for Breast and Gynecological Malignancies
The goal of this study is to assess the effect of brief mindfulness-guided meditations during radiation therapy (RT) for patients with anxiety related to RT for breast and gynecological cancers.
- Trial name
- Med-RT BG (NCT07166042)
- Testing
- 10-15 minute, Audio-Recorded Guided Mediation Practices
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Utah