Clinical trials: sponsored by University of Utah
Breast Cancer
Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment
The initial goal of the investigators interdisciplinary group of imagers, oncologists, neurologists, neuro-psychologists, and biostatisticians is to obtain proof of concept pilot data for eventual submission of a National Cancer…
- Trial name
- NCT02317783
- Testing
- [18F]Flutemetamol, [18F]fluoro-2-deoxy-D-glucose (FDG), Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Gastrointestinal Neoplasms
Ulixertinib (BVD-523) and Hydroxychloroquine in Patients W Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas
Open-label dose escalation of Ulixertinib combined with fixed dose of hydroxychloroquine.
- Trial name
- UTAH (NCT04145297)
- Testing
- Ulixertinib, Hydroxychloroquine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Headache, Stroke
Sphenopalatine Ganglion Block for the Treatment of Post-Stroke Headache
Determine the effects of sphenopalatine ganglion (SPG) block in post-stroke headache.
- Conditions
- Headache, Stroke, Ischemic Stroke
- Trial name
- NCT05365880
- Testing
- Liquid Lidocaine
- Where
- United States
- Sponsor
- University of Utah
Depression, Burnout, Professional
PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout
This project is an open-label randomized study looking at an 8-week Mindfulness-Based Stress Reduction (MBSR) curriculum vs. an 8-week MBSR curriculum + a group psilocybin-assisted psychotherapy intervention for frontline…
- Trial name
- PAPR (NCT05557643)
- Testing
- Psilocybin, Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Utah
Cardiogenic Shock
Establishing Physiologic Outcomes for Ventricular Unloading on VA ECMO
Aim 1: Prospective, observational analysis of the association between echocardiographic measures of cardiac function and left ventricular unloading on VA ECMO.
- Trial name
- NCT05658276
- Where
- 2 sites in United States, Canada
- Sponsor
- University of Utah
HER2-negative Breast Cancer
Functional Precision Oncology for Metastatic Breast Cancer
This is a pilot study to assess the feasibility of comprehensive genomic characterization and drug screening in metastatic breast cancer.
- Trial name
- FORESEE (NCT04450706)
- Testing
- Precision Medicine, Physican Decision Making
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Estrogen Receptor Positive Breast Cancer
[18F]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
This protocol is a companion imaging study that will add FES-PET/CT imaging to the FORESEE trial at HCI. This study will establish the feasibility of using FES-PET/CT imaging to guide therapeutic decision making for functional…
- Trial name
- NCT04727632
- Testing
- [18F]Fluoroestradiol (FES) PET/CT
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Anxiety, Burden, Dependency
Virtual Coaching to Maximize Dementia Caregivers' Respite Time Use
The "Time for Living \& Caring" (TLC) intervention is an online, self-administered intervention, with the purpose of providing informal family caregivers with resources, support, and education to maximize the benefit of their…
- Conditions
- Anxiety, Burden, Dependency, Caregiver
- Trial name
- TLC (NCT03689179)
- Testing
- Time for Living and Caring (TLC)
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Utah
Health Knowledge, Attitudes, Practice
Improving Health Insurance Literacy Among Utah's Hispanic Population
This is a test of an existing health insurance education program (HIEP) in the Utah Hispanic community (aged 18-64). The study will evaluate whether the HIEP delivered by Utah Health Policy Project (UHPP) staff improves…
- Trial name
- NCT04823975
- Testing
- Health Insurance Education Program (HIEP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Children With Medical Complexity
Self-management Intervention for Children With Chronic Medical Complexity: Pilot Feasibility Trial
The investigators have developed a tool to facilitate self-management for children with medical complexity (complex, multisystem chronic diseases) called MyChildCMC (My Child's Complex Medical Condition).
- Trial name
- NCT04470193
- Testing
- MyChildCMC app
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Brain Cancer
Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water
Purpose of Study This exploratory clinical study will investigate FMISO (fluoromisonidazole) in patients with (1) newly diagnosed primary malignant brain tumors (WHO [World Health Organization] Grade III or IV glial-based tumors)…
- Trial name
- NCT01246869
- Testing
- [18F]fluoro-2-deoxy-D-glucose (FDG), 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole [18F]-fluoromisonidazole, [15O]water
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Peutz-Jeghers Syndrome
Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome
Pilot study, Open-label, Phase II study of Everolimus. Objective: To determine if Everolimus can diminish large gastrointestinal polyps in patients with Peutz-Jeghers Syndrome.
- Trial name
- NCT00811590
- Testing
- Everolimus
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Pancreatitis, Graft, Pancreatic Transplant Post-Transplant Dysfunction Rejection
18F-Fluciclovine PET/CT in the Assessment of Pancreatic Transplants
Hypothesis 1: 18F-Fluciclovine PET/CT can correctly and easily identify the pancreatic allograft and determine its viability Aim 1: Assess whether 18F-Fluciclovine can identify the pancreatic allograft accurately and assess its…
- Trial name
- NCT04852523
- Testing
- 18F-fluciclovine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Utah
PreDiabetes, Prediabetic State
Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes
The goal of this randomized pilot clinical trial is to describe the feasibility of a couple-based lifestyle intervention and the study protocol in preparation for a future definitive randomized clinical trial.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05695170
- Testing
- PreventT2 (Individual intervention), PreventT2 Together (Couple-based intervention)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
Infant,Premature, Respiratory Failure
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
Very low birth weight infants are at increased risk of requiring prolonged duration of mechanical ventilation and multiple intubations, both of which are risk factors for ventilator-induced lung injury and BPD.
- Conditions
- Infant,Premature, Respiratory Failure, Respiratory Insufficiency, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT03558737
- Testing
- Nasal high-frequency jet ventilation (nHFJV), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Anemia
Pilot Feasibility Study of a Novel Non-invasive Device for Diagnosis of Anemia
In low-resource areas of the world, anemia screening relies on analyzing a blood sample and is generally carried out in health facilities.
- Trial name
- NCT06159348
- Testing
- Anemia Diagnostic Assistant (ADA), Serum hemoglobin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Utah
Major Depressive Disorder
5-HTP and Creatine for Depression
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT04395183
- Testing
- 5-Hydroxytryptophan 100 MG, Creatine monohydrate
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Utah
Hypoxic Ischemic Encephalopathy
Darbe Administration in Newborns Undergoing Cooling for Encephalopathy
Selective head cooling or whole body hypothermia has become the standard of care for neonatal hypoxia-ischemia encephalopathy (HIE).
- Trial name
- DANCE (NCT01471015)
- Testing
- Darbepoetin alfa
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Lumbar Facet Syndrome
A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
Chronic, non-neurogenic low back pain (CLBP) is a common condition that affects many individuals across their lives. The lumbar facet joint has been implicated as an important source of CLBP, with a prevalence of 15-45%.
- Trial name
- NCT03614793
- Testing
- Cooled Radiofrequency Ablation of Medial Branch Nerves versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Utah
Contraception
Ovarian Function With ENG Implant and UPA Use
Same day initiation of the etonogestrel (ENG) implant and oral ulipristal acetate (UPA) would overcome contraceptive access barriers to people capable of pregnancy with recent unprotected intercourse to ongoing contraception.
- Trial name
- NCT04291001
- Testing
- ENG implant, oral ulipristal acetate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah