Clinical trials: sponsored by University of Utah
Cancer-associated Pain
Pilot Study on the Effect of Intrathecal Opioids on Immune Function in Humans With Cancer Pain
The purpose of this study is to examine the changes in immune function, as measured by biomarkers in the blood, that happen with intrathecal (spinal) delivery of opioid medications for the treatment of moderate to severe cancer…
- Trial name
- NCT02151513
- Testing
- Intrathecal Pump Placement
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Utah
Diabetes Mellitus, Type 2, PreDiabetes
The Effect of 360 Video and MAPS on Enrollment in the DPP
We will conduct a three-armed randomized, clinical trial to test the incremental effectiveness of Mobile 360° Video and Motivation and Problem Solving in motivating individuals with Prediabetes to enroll in the Diabetes…
- Trial name
- NCT04746781
- Testing
- Mobile 360° Video intervention, Motivation and Problem Solving (MAPS), Risk notification/education
- Where
- United States
- Volunteers
- 818 people
- Sponsor
- University of Utah
Deep Vein Thrombosis, Pulmonary Embolism
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin
The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT03516656
- Testing
- Standard heparin dose, Real time heparin dose adjustment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Atrial Fibrillation, Venous Thromboses
Fearon Algorithm in Warfarin Patient Self-Management
This study aims to explore the feasibility of a novel, patient-specific algorithm for adjusting warfarin doses during chronic anticoagulation therapy.
- Conditions
- Atrial Fibrillation, Venous Thromboses, Heart Valve Diseases
- Trial name
- NCT03911661
- Testing
- Fearon warfarin dosing algorithm, Usual care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Low Back Pain
Optimization of Spinal Manipulative Therapy Protocols
Research on spinal manipulative therapy for individuals with low back pain has been hampered by a lack of understanding of which of the physiologic effects produced by spinal manipulation are related to clinical benefit, and how…
- Trial name
- NCT02868034
- Testing
- SMT, Mobilizing Exercises, Activation Exercises
- Where
- 2 sites in United States, Canada
- Volunteers
- 273 people
- Sponsor
- University of Utah
Chronic Pediatric Heart Failure
CRT Pilot Study for Children With Heart Failure
To collect information on pediatric patients receiving Cardiac Resynchronization Therapy (CRT) with permanent biventricular pacing (BVP) as a method of treating chronic heart failure.
- Trial name
- NCT00585065
- Testing
- CRT device implant
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Spinal Muscular Atrophy
Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy
This is an open label phase I/II clinical trial to assess safety, tolerability and potential effect on SMN mRNA and protein in vivo of a compound in which preliminary evidence supports a potential effect on SMN levels in vitro.
- Trial name
- NCT00374075
- Testing
- Valproic Acid
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Utah
Caries,Dental
Microbial Sampling of Carious Dentin
The School of Dentistry is seeking to determine whether viable microorganisms remain within tooth structure after conventional, mechanical removal of areas of tooth decay, prior to placement or replacement of tooth restorations…
- Trial name
- NCT04011605
- Testing
- Biological Sample of Carious Dentin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Pain
Pin Size Influence the Incidence of Knee Pain
It has been the investigators observation that large diameter traction pins cause more postoperative knee pain than smaller traction pins.
- Trial name
- NCT02170480
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Utah
Pain
LIA in Hip Arthroscopy Patients
The investigator's are conducting a randomized, blinded study to determine if the extra-capsular local infiltration analgesic (LIA) administration of 20ml 0.25% bupivacaine-epinephrine can improve the postoperative pain…
- Trial name
- NCT03070054
- Testing
- 20ml 0.25% bupivacaine-epinephrine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Utah
Infant,Premature, Bronchopulmonary Dysplasia
Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia
Multiple factors contribute to growth failure in infants with BPD, including poor nutrient stores, inadequate intake, increased losses, and increased needs.
- Conditions
- Infant,Premature, Bronchopulmonary Dysplasia, Growth Failure
- Trial name
- NCT03532555
- Testing
- Zinc Acetate, No supplemental zinc
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Utah
Alzheimer's Disease
Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET
Alzheimer's disease (AD) is the most common cause of progressive cognitive decline in the United States. AD is characterized by severe impairments in learning, memory and other cognitive abilities that significantly interfere…
- Trial name
- NCT01202994
- Testing
- 18F-Flutemetamol
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Utah
Dermatofibroma of Skin
Efficacy of 1540 Nanometer Erbium Glass Laser to Improve Benign Dermatofibromas
This study is to find a more effective treatment for itchy, painful or unsightly dermatofibromas, that will improve symptoms of itch and/or pain and/or improve the appearance of dermatofibromas.
- Trial name
- NCT03392935
- Testing
- 1540 nanometer Erbium glass laser
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Utah
Age-Related Macular Degeneration, Choroidal Neovascularization
Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD
The goals of this study are: To assess the impact of genetic testing based on how it alters behaviors, to assess the utility of serum biomarker measurement in combination with genetic testing, to assess the utility of genetic…
- Conditions
- Age-Related Macular Degeneration, Choroidal Neovascularization, Genetic Counseling
- Trial name
- NCT03024424
- Testing
- Early disclosure, Late disclosure
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
Stroke
Stroke Rehabilitation, Functional Recovery, and Cost-effectiveness
The investigators will determine the client and non-client variables associated with discharge to an inpatient rehabilitation facility vs. skilled nursing facility in individuals' post-stroke.
- Trial name
- NCT04279977
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Alzheimer Disease, Mild Cognitive Impairment
Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects
The primary objective of this study is to demonstrate that individuals with low short-term practice effects (STPE) on cognitive testing are more likely to be identified as "positive" on amyloid imaging than individuals with high…
- Trial name
- APPE (NCT03466736)
- Testing
- [18F]flutemetamol PET scan
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Utah
Infertility, Miscarriage
International NaProTechnology Evaluation and Surveillance of Treatment for Infertility and Miscarriage (iNEST)
NaProTechnology (NPT) is a treatment option for infertility or miscarriage that identifies issues in a couple's fertility and fixes them to the extent possible by medical intervention.
- Trial name
- iNEST (NCT01363596)
- Testing
- Creighton Model System in conjunction with Natural Procreative Technology (NPT)
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 834 people
- Sponsor
- University of Utah
Acute Kidney Injury
Noninvasive Measurements of Renal Perfusion During Cardiac Surgery
The purpose of this study is to assess the feasibility of measuring urine oxygen tension in cardiac surgery patient and the ability of peri-operative urine oxygen measurements to predict post-operative acute kidney injury.
- Trial name
- NCT03335865
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Sleep Deprivation, Delirium
Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU
The purpose of this study is to analyze a multi-component sleep/wake protocol for optimization of environmental factors (noise, light, nursing activities) as well as non-environmental factors (pain, mechanical support devices…
- Trial name
- NCT03313115
- Testing
- Sleep/Wake Protocol
- Where
- United States
- Volunteers
- 685 people
- Sponsor
- University of Utah
Peripheral Arterial Disease, Intermittent Claudication
Non-Contrast Enhanced Peripheral Magnetic Resonance Angiography
To systematically develop, test, and refine peripheral vascular electrocardiography-gated fast spin echo magnetic resonance imaging for the accurate diagnosis of peripheral arterial disease without gadolinium contrast.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Peripheral Vascular Disease
- Trial name
- NCT02823444
- Testing
- Magnetic Resonance Angiography
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Utah