Clinical trials: sponsored by University of Utah
Alzheimer's Disease
Biodistribution of 11C-PIB PET in Alzheimer's Disease, Frontotemporal Dementia, and Cognitively Normal Elderly
Alzheimer's disease (AD) is characterized by neuritic plaques, neurofibrillary tangles, and neuronal cell loss. Amyloid plaques are believed to play an integral role in AD.
- Trial name
- 11C-PIB PET (NCT00811122)
- Testing
- 11C-PIB PET Scan, FDG-PET Scan
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Utah
Post-operative Craniotomy Patients, Carotid Endarterectomy and Carotid Artery Stenosis Patients
Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit
To assess the efficacy of an intravenous nonnarcotic pain medication on controlling patient pain. To assess the effect of an intravenous nonnarcotic pain medication on patient sedation levels in neurocritically ill patients.
- Conditions
- Post-operative Craniotomy Patients, Carotid Endarterectomy and Carotid Artery Stenosis Patients, Post-op Spine Patients Admitted to the NCCU, Endovascular Patients Undergoing Intracranial Intervention
- Trial name
- NCT01948505
- Testing
- Intravenous acetaminophen
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Utah
Major Depressive Disorder
Neurobiology of Treatment Responses in MDD
The primary study intent is to examine biological mechanisms associated with acute and chronic treatment responses in major depressive disorder (MDD).
- Trial name
- NCT03068247
- Testing
- Duloxetine
- Where
- United States
- Sponsor
- University of Utah
Mild Cognitive Impairment, Dementia
Implications for Management of PET Amyloid Classification Technology
The main purpose of this study is to explore the impact of an amyloid positron emission tomography and computed tomography (PET/CT) scan on physician diagnosis and management, including drug management and care practices, for…
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer's Disease
- Trial name
- IMPACT (NCT02778971)
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid Use, Pregnancy Related
Serving Women Using Opioids During Pregnancy
The purpose of this study is to evaluate the effects of Mindfulness-Oriented Recovery Enhancement (MORE) on opioid misuse and parenting behavior among pregnant women using opioids.
- Trial name
- SWOOP (NCT03552120)
- Testing
- MORE, Supportive Psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
SARS CoV-2 Infection
A Pilot Study of Human Amniotic Fluid for COVID19 Associated Respiratory Failure
The purpose of this study is to test the effect of purified (acellular) amniotic fluid as a treatment for SARS CoV-2 (COVID19)-associated respiratory failure.
- Trial name
- NCT04319731
- Testing
- Human Amniotic Fluid
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Cardiovascular Diseases, Heart Diseases
Myocarditis Treatment Trial
To determine whether immunosuppressive treatment improved cardiac function in patients with biopsy-proven myocarditis.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocarditis
- Trial name
- NCT00000524
- Testing
- cyclosporine, prednisone
- Sponsor
- University of Utah
Fibromyalgia
Endogenous Opioid Systems and Symptom Change in Fibromyalgia
This study is designed to study brain mechanisms associated with symptoms and severity of Fibromyalgia. This will be accomplished by relating results from PET scans to self-reported and objective measures of disease severity.
- Trial name
- NCT02866461
- Testing
- No treatment
- Sponsor
- University of Utah
Substance-Related Disorders
Validating Interventions for Diverse Adolescents
The purpose of this study is to compare a culturally adapted and a non-culturally adapted group-based substance abuse treatment with Latino adolescents.
- Trial name
- VIDA (NCT01018654)
- Testing
- Standard Cognitive Behavioral Treatment, Culturally Adapted Cognitive-Behavioral Treatment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Utah
Moderate Sedation Training
Moderate Sedation Educational Software
We propose to develop and evaluate an interactive education software for administering moderate sedation by non-anesthesiologists.
- Trial name
- NCT00708760
- Testing
- paper based training, web based training
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Utah
Resilience, Stroke
Enhancing Resilience in Young Stroke Survivors With Res-ET
The proposed pilot study will explore the feasibility and preliminary impacts of a 6-week at-home group delivered inspiratory muscle strength training (IMST) exercise intervention on resilience in young stroke survivors.
- Trial name
- NCT05348044
- Testing
- Res-ET intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Utah
Brain Injuries, Traumatic, Spinal Cord Trauma
Characterization of Human Autoantibody Titers After Central Nervous System Insult
The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
- Conditions
- Brain Injuries, Traumatic, Spinal Cord Trauma, Intracranial Neoplasm
- Trial name
- CHAT CNS (NCT03089749)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Utah
Infant, Premature, Congenital Heart Disease
Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus
Patent ductus arteriosus (PDA) is a common problem in the neonatal intensive care unit and can be secondary to prematurity or congenital heart disease (CHD).
- Conditions
- Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
- Trial name
- NCT03551600
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Utah
Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration
Genetic Analysis of Congenital Diaphragmatic Disorders
The purpose of this study is to understand the genetic causes of congenital diaphragmatic disorders (CDD), namely congenital diaphragmatic hernia (CDH), eventration and hiatal hernia. Specifically, the investigators plan to: 1.
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration, Congenital Hiatal Hernia, Congenital Diaphragmatic Disorders
- Trial name
- NCT01243229
- Where
- 2 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pain, Osteoarthritis, Knee
Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention
This is a single-site, three-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a nurse-led, very brief, preoperative mindfulness-based intervention for hip and knee replacement patients will be…
- Conditions
- Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT05054595
- Testing
- Standard Pain Management, Audio-Recorded Mindfulness-Based Intervention, Nurse-Led Mindfulness-Based Intervention
- Sponsor
- University of Utah
Colorectal Cancer, Colorectal Neoplasms
Home-based HIIT to Improve CRC Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of CRC Recurrence
This 12-week, exercise study will assess the feasibility of a home-based high-intensity interval training (HIIT) program among colorectal cancer survivors and explore the impact of home-based HIIT compared to a standard…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma, Colonic Neoplasms
- Trial name
- NCT04080414
- Testing
- Home-based high-intensity interval training, Home-based moderate-intensity continuous exercise
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Chronic Pain
Behavioral Interventions for Active Duty Service Members and Veterans With Chronic Pain
The central aim of this proposed study is to test a multimodal, mindfulness-oriented intervention designed to disrupt the risk chain leading to prescription opioid dose escalation, opioid misuse and opioid addiction, which are…
- Trial name
- NCT02935621
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Support Group
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- University of Utah
Chronic Pain
One MORE for Chronic Pain
This study will be a single-site, two-arm randomized controlled trial conducted among chronic pain patients. Chronic pain patients will be randomized by a computer-generated randomization schedule with simple random allocation…
- Trial name
- NCT05194241
- Testing
- One MORE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Multiple Myeloma
Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma
This is a phase I, open-label trial of disulfiram in combination with copper gluconate in patients with treatment-refractory multiple myeloma.
- Trial name
- Repurpose-1 (NCT04521335)
- Testing
- Disulfiram, Copper Gluconate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Pharmacokinetics
Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers
This study is a single-center, open-label study of the plasma pharmacokinetics of amiloride nasal spray at three different doses in healthy volunteers.
- Trial name
- NCT04181008
- Testing
- Amiloride
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Utah