Clinical trials: sponsored by University of Utah
Macular Dystrophy, Corneal
Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy
The purpose of this study is to investigate whether taking 4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye.
- Trial name
- NCT00346853
- Testing
- 4-Methylpyrazole, saline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Neck Pain, Low Back Pain
PNE Effectiveness Cluster Trial
This is a cluster randomized trial that involves training regions of physical therapy clinics to use pain neuroscience education or continue with usual care.
- Conditions
- Neck Pain, Low Back Pain, Chronic Pain
- Trial name
- PNE (NCT03168165)
- Testing
- Pain neuroscience education training
- Where
- 41 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Utah
Pain, Satisfaction, Patient
Examining the Impact of Mindfulness on Patients' Experience of Osteopathic Manipulation
This is a single site, two-arm, parallel group pilot randomized controlled trial examining the effect of coupling a brief mindfulness-based intervention with an osteopathic manipulation session for pain patients.
- Trial name
- NCT04477278
- Testing
- Mindfulness Meditation, History of Osteopathy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Utah
Advanced Malignancies, Urothelial Carcinoma
Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies
This is an open label nonrandomized Phase I/ IIA trial designed to assess the safety, tolerability, and efficacy of apatinib in combination with pembrolizumab.
- Conditions
- Advanced Malignancies, Urothelial Carcinoma, MSI-H or dMMR Solid Tumors, Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
- Trial name
- APPEASE (NCT03407976)
- Testing
- Apatinib, Pembrolizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Venous Thromboembolism, Deep Venous Thrombosis
Fixed Versus Weight-Based Enoxaparin Dosing in Thoracic Surgery Patients
The aim of this research is to better understand how patient-level factors can be used to predict the appropriate enoxaparin dose to maximize venous thromboembolism (VTE) risk reduction and minimize bleeding.
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Surgery
- Trial name
- NCT03251963
- Testing
- Fixed Dose Enoxaparin, Variable Dose Enoxaparin
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Utah
Castration-Sensitive Prostate Carcinoma, Metastatic Prostatic Adenocarcinoma
Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer
This phase II trial studies how well docetaxel or abiraterone acetate work when combined with androgen deprivation therapy (ADT) in treating patients with hormone sensitive prostate cancer that has spread to other parts of the…
- Conditions
- Castration-Sensitive Prostate Carcinoma, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer, Stage IVA Prostate Cancer
- Trial name
- ACADEMIC (NCT03827473)
- Testing
- Abiraterone Acetate, Antiandrogen Therapy, Docetaxel
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Mild Cognitive Impairment
Cognitive Training and Practice Effects in Mild Cognitive Impairment
The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment.
- Trial name
- NCT02301546
- Testing
- computerized cognitive exercises
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- University of Utah
Parkinson's Disease
Mobile Decision Support System for Nurse Management of Neuromodulation Therapy
The purpose of this study is to test the use of a clinical decision support tool for postoperative care of Parkinson's disease patients who are treated using deep brain stimulation (DBS).
- Trial name
- NCT02474459
- Testing
- iPad-Based Clinical Support Care, Standard Clinical Care
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Utah
Acute Pain
Psychosocial Support for Pre-operative Pain and Distress
The purpose of this randomized study is to determine the impact of three different types of psychosocial support delivered by mental health professionals to pre-operative joint replacement patients.
- Trial name
- Mind-Body JRA (NCT03665727)
- Testing
- Mindfulness, Suggestion, Psychoeducation
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Utah
Bronchiolitis
The Bronchiolitis Follow-up Intervention Trial
This study evaluates the value of routine follow-up with a child's pediatrician after hospitalization for bronchiolitis. Parents of half of participants will be instructed to follow-up with the child's pediatrician regardless of…
- Trial name
- BeneFIT (NCT03354325)
- Testing
- Scheduled PCP follow-up, As needed PCP follow-up
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- University of Utah
Stroke, Depression
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
This study aims to pilot test an 8-week, self-administered dyadic (couples-based) positive psychology intervention for couples coping with stroke using a randomized, waitlist control design.
- Conditions
- Stroke, Depression, Depressive Symptoms, Post-stroke Depression
- Trial name
- RESToreD (NCT03335358)
- Testing
- Dyadic (couples-based) positive psychology intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Utah
Acetabular Fracture, Pelvic Fracture
Hip Strength and Nerve Palsy After the Modified Stoppa Approach to Acetabular Fracture Reduction and Fixation
The purpose of this prospective study is to compare hip adductor strength and obturator nerve palsy between acetabular fracture patients whose fracture was reduced and fixated using the modified Stoppa approach (subjects) and…
- Trial name
- NCT01763359
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Utah
Soft Tissue Sarcoma
Pilot Study: Dynamic Contrast-enhanced Magnetic Resonance Imaging(DCE-MRI)for Assessing Tumor Vascularity and Permeability in Soft Tissue Sarcoma Treated With Preoperative Radiotherapy Followed by Surgical Resection
This is a pilot study to determine the diagnostic value of dynamic contrast enhancing MRI (DCE-MRI) in soft tissue sarcoma for assessment of tumor radiographic changes in vascular permeability and microvessel density before and…
- Trial name
- NCT01575951
- Testing
- MRI-DCE
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Stroke, Intracranial Atherosclerosis
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
This will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and intracranial atherosclerotic disease are randomized to either drug or…
- Conditions
- Stroke, Intracranial Atherosclerosis, Intraplaque Hemorrhage
- Trial name
- PINNACLE (NCT03507374)
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Low Back Pain
The Development of a Cognitive Reassurance Training Program
The focus of this proposal is to evaluate the feasibility of a cognitive reassurance training program by examining changes in physical therapist low back pain beliefs and skills with training and evaluating the quality with which…
- Trial name
- NCT03256617
- Testing
- Cognitive reassurance training
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Utah
Acute Pain
Psychosocial Support for Acute Hospital Pain and Distress
The purpose of this randomized study is to determine the impact of three different types of psychosocial support delivered by social workers to patients reporting uncontrolled pain during a hospital stay.
- Trial name
- NCT02590029
- Testing
- Mindfulness, Suggestion, Psychoeducation
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Utah
Chronic, Non-neuropathic Back Pain
Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation
The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs.
- Trial name
- NCT02935465
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Support Group
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
Heart Failure
Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
Heart failure remains a major cause of morbidity and mortality. Many patients with heart failure receive support from a left ventricular assist device (LVAD) at some point in the course of their disease.
- Trial name
- NCT02547766
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Abuse of Anabolic Steroids
Intranasal Delivery of Testosterone and Its Effect on Doping Markers
Hypothesis: Intranasal administration of exogenous testosterone results in a characteristic profile during anti-doping testing, which is different than the profile seen when testosterone is administered into muscle, on skin or…
- Trial name
- Intranasal (NCT02611154)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Utah
Appendicitis, Pain, Postoperative
Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy
There is concern that pain prescription after outpatient pediatric surgical procedures is excessive and is in excess of patient need.
- Trial name
- NCT03528343
- Testing
- Non-narcotic pain control
- Where
- United States
- Sponsor
- University of Utah