Clinical trials: sponsored by University of Utah
Acute Myeloid Leukemia, AML
Decitabine Maintenance in Elderly Acute Myeloid Leukemia Patients
The study aims at determining the feasibility of using maintenance Decitabine therapy following remission induction and consolidation in elderly Acute Myeloid Leukemia patients who are fit for aggressive therapy.
- Trial name
- NCT01149408
- Testing
- Decitabine (Dacogen)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Cancer
Bevacizumab (Avastin®) + Erlotinib as First-line Therapy for Stage IIIB/IV or Recurrent, Non-squamous Cell Lung Cancer
In an attempt to improve the therapeutic index for initial therapy of metastatic NSCLC, the combination of bevacizumab and erlotinib is being proposed as first-line treatment in place of conventional chemotherapy.
- Trial name
- NCT00585377
- Testing
- Bevacizumab and Erlotinib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Healthy
In Vivo Assessment of Silver Biomaterial Nano-Toxicity
Nanotechnology is the controlled generation and manipulation of matter in dimensions less than 100 nm. Silver has been used for its bactericidal properties.
- Trial name
- NCT01243320
- Testing
- 10ppm Oral Silver Particle, 32ppm Oral Silver Particle
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cancer
Chemoradiation +Gemcitabine +Continuous 5-FU (Fluorouracil) Followed by High Dose Brachytherapy/Stereotactic Radiation Boost in Locally Advanced Intra/Extrahepatic Cholangiocarcinoma
OBJECTIVES: This study proposes to evaluate the feasibility of delivery of this treatment in terms of toxicity. If toxicity is not acceptable, the treatment is not feasible.
- Trial name
- NCT00983541
- Testing
- Fluorouracil (5-FU), Brachytherapy or SBRT (Stereotactic body radiation therapy), Gemcitabine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Total Joint Revisions
Retrieval and Analysis of Orthopedic Implants at Revision Arthroplasty Surgery
The goal of this is to improve durability of total joint replacements in patients, thereby improving clinical outcomes and implant performance.
- Trial name
- NCT01425021
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Utah
Atrial Fibrillation
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
The fMRI study is a prospective study with the objective of evaluating the effects of the autonomic central nervous system on the regulation of heart rate in patients with atrial fibrillation (AF).
- Trial name
- fMRI (NCT02524028)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Femoroacetabular Impingement, Dysplasia
Hip Pathomorphology in Collegiate Athletes and Controls
The primary objective of this study is to investigate factors hypothesized to influence the prevalence of hip pathomorphology (femoroacetabular impingement, dysplasia) in young adults.
- Trial name
- NCT01799200
- Volunteers
- 63 people
- Sponsor
- University of Utah
Shoulder Dislocation
Results of Rotator Cuff Repair
The primary objective of this research is to examine the result of rotator cuff repairs following acute shoulder dislocations and to investigate whether timing of surgery following acute shoulder dislocations affects patients…
- Trial name
- NCT01549912
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Utah
Clavicle Fracture
Percutaneous Versus Open Plate Fixation of Diaphyseal Clavicle Fractures
This is a prospective, level II evidence comparison between two cohorts. This study is designed to compare the percutaneous versus open approach for plate fixation of diaphyseal clavicle fractures.
- Trial name
- NCT01405703
- Testing
- xrays
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Utah
Tibial Fractures, Malleolar Fractures
Intramedullary Nailing of Tibia Fractures
Currently, the treatment of choice for tibial fracture is intramedullary nailing. This procedure has been shown to have low rates of infection, high rates of bone healing, and a faster return to weight bearing and activity in…
- Trial name
- NCT01797640
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melanoma
A Study of Intratumoral Injection of Interleukin-2 and Ipilimumab in Patients With Unresectable Stages III-IV Melanoma
This is a single center, open phase I dose escalation study. This study will assess the highest tolerable intratumoral dose of ipilimumab (Yervoy) in combination with IL-2 (Proleukin) in patients with unresectable stages III-IV…
- Trial name
- NCT01672450
- Testing
- Intratumoral Ipilimumab and Interleukin-2
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Spinal Muscular Atrophy Type I
CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I
This is a multi-center trial to test safety and evaluate early treatment intervention with valproic acid and carnitine in moderating SMA symptoms of Type I infants.
- Trial name
- NCT00661453
- Testing
- Valproic Acid and Levocarnitine
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 40 people
- Sponsor
- University of Utah
Type 2 Diabetes Mellitus, Prediabetes
Effect of Iron Reduction by Phlebotomy for Type 2 Diabetes
High tissue iron is a risk factor for diabetes even within the broad normal range of normal human values. In order to demonstrate the benefits of reducing iron on glucose homeostasis and to better define the parameters for larger…
- Trial name
- NCT02468037
- Testing
- Phlebotomy
- Volunteers
- 12 people
- Sponsor
- University of Utah
Craniosynostosis
Endoscopic Treatment for Isolated, Single Suture Craniosynostosis
This is a prospective study to evaluate outcomes in patients undergoing endoscopic craniectomy for isolated, single-suture craniosynostosis.
- Trial name
- NCT00769847
- Testing
- Endoscopic strip craniectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Idiopathic Urticaria
Etanercept for the Treatment of Chronic Urticaria
The purpose of this study is to evaluate the safety and efficacy of etanercept for patients with chronic idiopathic urticaria unresponsive to antihistamines.
- Trial name
- EtanerceptCIU (NCT01030120)
- Testing
- etanercept
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Low Birth Weight Infant
Platelet-activating Factor Acetylhydrolase (Paf-ah) Gene Expression
This is a prospective observational study to determine whether there is an association between the presence of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms and the development of chronic lung disease in…
- Trial name
- NCT00747240
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- University of Utah
Low Birth Weight, Small for Gestational Age
Epigenetic Markers of B-Cell Function in Low Birth Weight Infants
Low birth weight (LBW) status (< 10% for gestational age at birth) is associated with increased risk for diseases such as type II diabetes mellitus, hypertension, chronic obstructive pulmonary disease and coronary artery disease…
- Conditions
- Low Birth Weight, Small for Gestational Age, Immunodeficiency
- Trial name
- NCT00925925
- Testing
- Cord blood collection for analysis
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Intraventricular Hemorrhage, Premature Infants
Intraventricular Hemorrhage and Post Hemorrhagic Ventricular Dilation: Natural Course, Treatment, and Outcome
Intraventricular hemorrhage and its resultant post-hemorrhagic hydrocephalus are significant risk factors for the development of neurodevelopmental delays in preterm infants.
- Trial name
- NCT00957840
- Testing
- NIRS, aEEG, and CSF concentration of biomarkers
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Utah
Pregnancy
Effects of Dairy Foods on Adolescent Pregnant Mothers and Their Newborns
The purpose of the study is to evaluate the effects of different dietary calcium have on the pregnant teen mother and her newborn.
- Trial name
- NCT00320125
- Testing
- Orange juice plus calcium, Dairy products
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pulmonary Function
Pulmonary Function During Prone and Supine Positioning in NICU Infants Requiring Assisted Ventilation
This study seeks to determine in Neonatal Intensive Care Unit (NICU) patients specific improvements in pulmonary function which may occur when an infant is ventilated in the prone as compared to the supine position.
- Trial name
- NCT00749762
- Where
- United States
- Sponsor
- University of Utah